Orthopaedic Research Laboratory Departmental Seminars

McKay Orthopaedic Research Laboratory Seminars

Seminars 2018

November 19, 2018

Tamara Alliston, PhD, University of California, San Francisco, "The Central Role of Osteocytes in Skeletal and Systemic Homeostasis and Disease"

November 19, 2018

Karl Lewis, PhD, Indiana University School of Medicine, "The development of intravital imaging techniques for the study of osteocyte calcium signaling in vivo"


Seminars 2016

January 21, 2016

Eve Donnelly, PhD, Cornell University, "Multiscale Mechanical and Compositional Characterization of Bone Tissue in Health and Disease"


Seminars 2013-15

November 23, 2015

Louis DeFrate, PhD, Associate Professor, Department of Orthopaedic Surgery, Duke University "In Vivo Joint Function and Dysfunction: Implications for Early Onset Osteoarthritis"


Seminars 2010-12

December 20, 2012

John T. Connelly, Ph.D., Blizard Institute, "Insights into the biophysical regulation of epidermal cell fate using engineered micro-environments"

December 10, 2012    

Nadeen O. Chahine, Ph.D., Hofstra North Shore LIJ, "Identifying Mechanisms of Injury and Repair in the Intervertebral Disc"

December 4, 2012

Kimberly Cooper, Ph.D., Harvard Medical School, "Development and Evolution of Form in the Vertebrate Limb"

November 29, 2012

Frank Beier, Ph.D., The University of Western Ontario, "Signaling Pathways in Skeletal Development and Osteoarthritis"

October 24, 2012

Joel D. Boerckel, Ph.D., Cleveland Clinic, "Mechanical and Biological Regulation of Tissue Regeneration"

May 9, 2012

Christian Gerber, Prof. Dr. med., University of Zurich - Uniklinik Balgrist, "The Effect of Tendon Tearing on the Rotator Cuff Muscles"

December 5, 2011

Jenna Galloway, PhD, Harvard Medical School, "Regulation of Progenitor Cell Specification and Patterning in the Musculoskeletal System"

October 21, 2011

Stavros Thomopoulos, PhD, Washington University, "Structure, Biomechanics, and Mechanobiology in the Attachment of Tendon to Bone"

October 20, 2011

James L. Cook, PhD, University of Missouri, "Translational Modeling of Joint Disease"

May 26, 2011

Leesa Galatz, MD, Washington University School of Medicine, "Rotator Cuff Muscle Degeneration

April 25, 2011

Jean B. Regard, PhD, National Institutes of Health, "G Protein Signaling in Skeletal Development and Disease"

October 25, 2010

Ryan M. Porter, PhD, Harvard Medical School, "Proinflammatory Challenge to Chondrogenesis in situ"

July 13, 2010

Xiaowei Sherry Liu, PhD, Columbia University Medical Center, "Clinical Imaging and the Mechanical Modeling of Bone"

June 3, 2010

Evan L. Flatow, MD, The Mount Sinai School of Medicine, "Understanding Tendon Fatigue Damage"

June 1, 2010

Michael L. Sohaskey, PhD, University of California, "Novel Molecular Pathways in Skeletal Development, Homeostasis and Repair"

May 6, 2010

Frank Beier, PhD, University of Western Ontario, "TGFa Signaling in Cartilage Development and Osteoarthritis"


Orthopaedic Research Club (ORC) Seminars

ORC is a platform for promoting cooperative interaction among investigators who engage in musculoskeletal research at the University of Pennsylvania and neighboring institutes.

Seminars 2018

November 28, 2018

Xin Li, PhD, New York University, "Altered bone metabolism by hyperglycemia: a new function of an old metabolite"

October 31, 2018

Jormay Lim, PhD, University of Pennsylvania, "Primary cilia are essential for cell alignment and polarity during bone development through regulating Ceramide-PKCz apicobasal polarity signaling"

Christina Mundy, PhD, Children’s Hospital of Philadelphia, "Potential therapeutic targets to reduce osteochondromas in patients with Hereditary Multiple Exostoses"

October 4, 2018

Brya Matthews, PhD, University of Auckland, "Identification of periosteal progenitors involved in bone healing"

September 26, 2018

Anh Le, DDS, PhD, Penn Dental Medicine, "Large Gap Peripheral Nerve Regeneration with Orofacial Stem Cells Based Nerve Guidance Conduits"

August 29, 2018

David Paglia, PhD, Rutgers University, "Insulin-mimetic salt induces of bone formation and inhibits osteoclast differentiation and fusion to restore cortical porosity in a type I diabetic-induced osteolysis rat model"

June 19, 2018

Andrew Kuntz, MD, University of Pennsylvania, "Rotator Cuff Repair - From Bench to Bedside, Challenges and Opportunities"

May 30, 2018

Noriaki Ono, DDS, PhD, University of Michigan School of Dentistry, "Skeletal/mesenchymal stem cells: how much do we know about them? A lineage-tracing perspective"

April 25, 2018

Joel Boerckel, PhD, University of Pennsylvania, "Forceful feedback: mechanosensation in cell motility and morphogenesis"

March 28, 2018

Christopher Price, PhD, University of Delaware, "New Therapeutic Strategies for Preventing Cartilage Degeneration and Post-Traumatic Osteoarthritis"

February 21, 2018

Maurizio Pacifici, PhD, Children’s Hospital of Philadelphia, "Morphogenesis of articular cartilage: implications for repair strategies"

January 17, 2018

Scott Levin, MD, FACS, University of Pennsylvania, "Hand transplantation: current challenges and future prospects"


Seminars 2016-17

November 29, 2017

Nancy Pleshko, PhD, Temple University, "Novel Spectroscopic Imaging Tools for Assessment of Musculoskeletal Tissues"

October 25, 2017

Ryan Tomlinson, PhD, Thomas Jefferson University, "Inflammatory Signals in Stress Fracture Risk and Repair"

September 28, 2017

Danielle Rux, PhD, Children’s Hospital of Philadelphia, "Hox Genes in the Adult Skeleton: Patterning Cues Beyond Embryonic Development"

September 28, 2017

Xia Zhao, University of Pennsylvania, "In vivo Bone Quality Assessment by Phosphorus and Proton MRI"

August 30, 2017

Michael Levine, MD, MACE, FAAP, FACP, Children’s Hospital of Philadelphia, "Vitamin D deficiency in the 21st Century: New Insights into an Old Problem"

June 28, 2017

Mei Wan, PhD, Johns Hopkins University School of Medicine, "Mechanisms of PTH Bone Anabolic Action - New Perspectives On An Old Topic"

May 24, 2017

Li-Hsin (Leo) Han, PhD, Drexel University, College of Engineering, "Micro-noodles" for Cartilage Repair: A Strategy to Achieve Tunable Cell shape, Mechanosensing, and ECM organization in 3-D"

April 14, 2017

Li Zeng, PhD, Tufts University School of Medicine, "Regulators of cartilage development and maintenance"

March 28, 2017

Louis Soslowsky, PhD, University of Pennsylvania, "Tendon Healing in a Rotator Cuff Animal Model"

February 22, 2017

Noreen Hickok, PhD, Thomas Jefferson University, "Infections in synovial fluid: new challenges"

January 24, 2017

Nat Dyment, PhD, University of Pennsylvania, "Defining the lineage of tendon and ligament cells"

December 7, 2016

Shuying Yang, PhD, University of Pennsylvania, School of Dental Medicine, "Mechanism of Ciliary Intraflagellar Transport Protein in Bone Formation"

November 2, 2016

Simon Tang, PhD, Washington University in St. Louis, "Multiscale Mechanisms of Low Back Pain"

September 28, 2016

Chamith Rajapske, PhD, University of Pennsylvania, "Recent Developments in Imaging Techniques for Evaluation of Bone Disorders"

July 27, 2016

Harvey Smith, MD, University of Pennsylvania, "Applied MRI Quantitative Imaging Sequences and Tissue Engineering for the Treatment of Intervertebral Disc Degeneration"

June 6, 2016

Chi-der Chen, PhD, University of Pennsylvania, School of Dental Medicine, "Mesenchymal stem cell transplantation identifies miR151-5p as a therapeutic target for systemic sclerosis"

June 6, 2016

Satoru Otsuru, PhD, Nationwide Children's Hospital, "Understanding the mechanism of bone growth after MSC infusion"

May 25, 2016

Carla Scanzello, MD, PhD, University of Pennsylvania, "Inflammatory pathway activation in osteoarthritis: insights from patients and animal models"

April 27, 2016

Andrzej Fertala, PhD, Thomas Jefferson University, "Prevention of the Post-traumatic Fibrotic Response in Joints"

March 23, 2016

Herb Sun, PhD, Albert Einstein College of Medicine, "The role of CITED2 in cartilage and tendon: A basic study searching for translation"

February 24, 2016

Eiki Koyama, DDs, PhD, Children's Hospital of Philadelphia, "The roles of Indian hedgehog in temporo-mandibular joint (TMJ) development and postnatal function"

January 27, 2016

Jason Burdick, PhD, University of Pennsylvania, "Engineering Hydrogels for Cartilage Repair"


Seminars 2014-15

Dec 2, 2015

Yeijia Zhang, PhD, University of Pennsylvania, "Intervertebral disc degeneration and repair"

October 28, 2015

Foteini Mourkioti, PhD, University of Pennsylvania, "Regenerative stem cell therapies to restore diseased skeletal muscles"

September 23, 2015

Yu Usami, Children's Hospital of Philadelphia, "Contribution of Wnt/b-catenin-Responsive Cells to Articular and Growth Plate Cartilage Growth"

September 23, 2015

Jason Ashley, PhD, University of Pennsylvania, "Modulation of osteoclast function: finding a niche in Notch signaling"

August 26, 2015

Samir Mehta, MD, University of Pennsylvania, "Trying to Make Sense of it All:The Regulation of Fracture Healing in a Trauma Setting"

July 29, 2015

Lin Han, PhD, Drexel University, "Nanomechanics: A Novel Interdisciplinary Tool to Uncover the Pathogenesis of Osteoarthritis"

June 24, 2015

Abhishek Chandra, PhD, University of Pennsylvania, "Radiotherapy Induced Bone Damage: Basics to Therapeutics"

June 24, 2015

Chantal de Bakker, University of Pennsylvania, "Effects of Pregnancy, Lactation, and Weaning on Maternal Bone Quality"

May 27, 2015

Sunday Akintoye, BDS, DDS, MS, University of Pennsylvania, School of Dental Medicine, " Skeletal Stem Cells: is the jaw bone connected to the hip bone?"

April 22, 2015

Lacklan Smith, PhD, University of Pennsylvania, "Unraveling the Etiology of Spine Disease in Mucopolysaccharidosis Disorders"

March 18, 2015

Mindy George-Weinstein, PhD, Cooper Medical School of Rowan University, "Roles of Myo/Nog Cells in Embryogenesis, Wound Healing and Neuroprotection"

Februay 25, 2015

Liyun Wang, PhD, University of Delaware, "Osteocyte’s hairy pericellular matrix in mechanosensing"

December 10, 2014    

Songtao Shi, DDS, MS, PhD, University of Pennsylvania, School of Dental Medicine, "Mesenchymal stem cells: from clinics to bench-top and back"

October 22, 2014

Federica Sgariglia, PhD, Children’s Hospital of Philadelphia, "Previously unsuspected defects in the cranial base of a mouse model of Hereditary Multiple Exostoses"

October 22, 2014

Brianne Connizzo, University of Pennsylvania, "In situ fibril stretch and sliding is location-dependent in mouse supraspinatus tendons"

September 24, 2014 

X. Lucas Lu, PhD, University of Delaware, "Prevention and Treatment of Post-traumatic Osteoarthritis"

August 13, 2014  

Jaimo Ahn, MD, PhD, FACS, University of Pennsylvania, "Enhancing fracture healing: lessons from our rodent friends"

June 25, 2014 

Girish Ramaswamy, PhD, University of Pennsylvania, "GNAS inactivation in Progressive Osseous Heteroplasia (POH) and skeletal development"

June 25, 2014 

Spencer Szczesny, University of Pennsylvania, "GNAS inactivation in Progressive Osseous Heteroplasia (POH) and skeletal development"

May 28, 2014  

Masahiro Iwamoto, PhD, DDS, Children's Hospital of Philadelphia, "Specification and maintenance of permanent articular cartilage"

April 30, 2014    

Elisabeth Barton, PhD, University of Pennsylvania, School of Dental Medicine, "Forces and factors from muscle that modulate bone"

March 26, 2014  

Dana Graves, DDS, DMSc, University of Pennsylvania, School of Dental Medicine, "Osteoblastic cells regulate the response of bone to inflammation"

Februay 26, 2014  

Theresa Freeman, PhD, Thomas Jefferson University, "Regeneration - ASK1, can it provide some answers?"

January 15, 2014    

Robert Mauck, PhD, University of Pennsylvania, "Material and Mechanobiologic Considerations for Engineering Dense Connective Tissues"


Institute for Regenerative Medicine (IRM) Advances in Musculoskeletal Regeneration Seminars

Seminars 2017-2018

December 7, 2018

Robert Krauss, PhD, Mount Sinai, "Niche regulation of muscle stem cell quiescence and activation"

November 9, 2018

Vittorio Sartorelli, MD, PhD, NIH/NIAMS, "Enhancing Expression by Enhancer RNAs"

May 8, 2018

Sara Wickström, MD, PhD, University of Helsinki, "Regulation of stem cell fate through niche-derived signals and mechanical forces"

April 24, 2018

Christopher Evans, PhD, Mayo Clinic, "Orthopedic Applications of Gene Therapy"

March 27, 2018

Eben Alsberg, PhD, Case Western Reserve University, "Modular inductive high-density cell culture systems for engineering complex tissues"

February 23, 2018

Nat Dyment, PhD, University of Pennsylvania, "Tenocytes, Tenoblasts, and Tenoclasts(?): Defining the Cell Types within Tendons"

February 23, 2018

Alex Hughes, PhD, University of Pennsylvania, "Testing the design rules of tissue curvature in development"

January 26, 2018

Bradley Olwin, PhD, University of Colorado, "How are Muscle Stem Cells Numbers Maintained?"

December 15, 2017

Ivo Kalajzic, PhD, University of Connecticut Health Center, "Identifying different Osteoprogenitors and Understanding Their Role in Bone Repair"

November 10, 2017

Jenna Galloway, PhD, Massachusetts General Hospital, Harvard Stem Cell Institute, "Insights into tendon developmental plasticity and regenerative biology using zebrafish and mice"

October 27, 2017

Srihari Sampath, MD, PhD, MPhil, Genomics Institute of the Novartis Research Foundation, "Skeletal muscle, from generation to regeneration"

September 12, 2017

Linda Sandell, PhD, Washington University, "Cartilage Repair and Osteoarthritis in Genetic Mouse Models"


Seminars 2016-2017

June 7, 2017

Nidhi Bhutani, PhD, Stanford University, "Unlocking the Secrets of Young Cartilage to Enhance Regeneration and Repair"

May 9, 2017

Denis Guttridge, PhD, The Ohio State University College of Medicine, "NF-kB Signaling in Muscle Growth and Disease"

April 4, 2017

Laurie Goodrich, DVM, PhD, Colorado State University, College of Veterinary Medicine, "MSC’s and immunomodulation: are we moving closer to allogeneic use?"

February 17, 2017

Douglas Millay, PhD, University of Cincinnati, "Mechanisms and applications of muscle stem cell fusions"

January 20, 2017

April Craft, PhD, Boston Children's Hospital, "Potential Therapeutics Applications of Human Pluripotent Stem Cell-Derived Cartilage"

December 2, 2016

Steve Thomopoulos, PhD, Columbia University, "Biologically inspired solutions for attaching dissimilar materials"

November 4, 2016

Megan Killian, PhD, University of Delaware, "FGF signaling during development of musculoskeletal interfaces"

November 4, 2016

Evangelia Bellas, PhD, Temple University, "Adipose Tissue Engineering: The Big Picture"

October 12, 2016

Michael A. Rudnicki, OC, PhD, FRSC,University of Ottawa, "Molecular regulation of muscle stem cell function"


Seminars 2015-2016

June 24, 2016

Andrew Brack, PhD, University of California, "Skeletal muscle stem cells: Regeneration and Aging"

May 17, 2016

Alessandra Sacco, PhD, Sanford Burnham Medical Research Institute, "Microenvironmental regulation of skeletal muscle stem cell function"

April 19, 2016

Charles Gershach, PhD, Duke University, "Genome and Epigenome Editing for Gene Therapy and Programming Cell Fate"

March 11, 2016

Eileen M. Shore, PhD, University of Pennsylvania and Maurizio Pacifici, PhD, Children’s Hospital of Philadelphia
"Heterotopic ossification, a disorder of mis-directed cell fates: pathogenesis and possible treatments"

January 29, 2016

Dennis E. Discher, PhD, University of Pennsylvania, "Matrix, Contractility, & Nucleus as a Polymeric Continuum: from striated muscle to immune therapy for solid tumors"

December 11, 2015

Penney Gilbert, PhD, University of Toronto, “Molecular consequences of biophysical changes in the muscle stem cell niche”

November 6, 2015

Fabio Rossi, MD, PhD, University of British Columbia, Vancouver, Canada, "Innate Immune Control of Fibrogenesis during Tissue Regeneration"

October 12, 2015

Robert E. Guldberg, PhD, Georga Institue of Technology, "The Perils and Promise of Regenerative Medicine: Emerging Trends"


McKay Young Investigator Seminars

This seminar series was designed to highlight the research and achievements of up and coming young scientists in the McKay Orthopaedic Research Lab. The goal of this seminar series is to provide a forum for senior graduate students, post docs and research associates who are poised to embark on the next stage of their careers to present their work to the department, and to stimulate discussion and collaboration between individual McKay labs.

Seminars 2018

December 4, 2018

Cheng Zhou PhD, Postdoctoral Fellow, Scanzello/Dodge Labs "Elucidating the role of inflammatory cells in osteoarthritis"

December 4, 2018

Danielle Rux PhD, Postdoctoral Fellow, Pacifici Lab, "Understanding Roles for the Primary Cilium During
Postnatal Articular Cartilage Morphogenesis"

October 9, 2018

Alexandra Stanley, PhD Student Mourkioti/Shore Labs, "Aberrant muscle tissue repair by mutant ACVR1/ALK2 FOP progenitor cells – implications for heterotopic ossification"

October 9, 2018

Edward Bonnevie PhD, Postdoctoral Fellow Mauck Lab, "Disruption of boundary constraints activates aberrant mechano-sensing in injured intervertebral discs"

August 14, 2018

Hongbo Zhao, Visiting PhD Student, Liu Lab, "Cyclic and Alternating Parathyroid Hormone (PTH) and Alendronate Treatment Regimens Further Improve Bone Microarchitecture and Strength Beyond Daily and Cyclic PTH Regimens"

August 14, 2018

Catherine Bautista, Graduate Student, Dyment Lab, "Identifying a Novel Subset of Tendon Cells"

June 5, 2018

Will Towler, Graduate Student, Shore Lab, "Regulation of phalangeal joint development by ACVR1 in fibrodysplasia ossificans progressiva"

June 5, 2018

Su Chin Heo, Research Associate, Mauck Lab, "Nuclear Softening Expedites Interstitial Cell Migration in Dense Connective Tissues"

April 10, 2018

Zak Beach, Graduate Student, Soslowsky Lab, "The Surprising Roles of Decorin and Biglycan during Tendon Homeostasis"

April 10, 2018

Luqiang Wang, Graduate Student, Qin Lab, "Prior focal radiation causes atrophic nonunion fracture in mice"

February 27, 2018

Devon Mason, Graduate Student, Boerckel Lab, "Persistent cell motility requires transcriptional feedback of cytoskeletal-focal adhesion equilibrium by YAP/TAZ"

February 27, 2018

Justin Bendigo, Graduate Student, Smith Lab, "Preconditioning of mesenchymal stem cells to enhance survival and extracellular matrix production in the intervertebral disc"


Seminars 2017

October 10, 2017

Yihan Li, Graduate Student, Liu Lab, "Effects of Reproduction and Lactation on Maternal Bone Mechano-Sensitivity"

October 10, 2017

Maryam Sharifi-Sanjani, Postdoctoral Fellow, Mourkioti Lab, "Telomere Dynamics in Cardiac Muscle"

August 15, 2017

Salin Chakkalakal, Senior Research Investigator, Shore Lab, "Development and application of novel FOP mouse models for investigating heterotopic ossification and drug development"

August 15, 2017

Cheng Zhou, Postdoctoral Fellow, Dodge Lab, "Enhanced phagocytic capacity endows chondrogenic progenitor cells with a novel scavenger function within injured cartilage"

June 6, 2017

Xiaoyuan Ma, Postdoctoral Fellow, Qin Lab, "Subchondral bone plate sclerosis during late osteoarthritis is mediated by loading-induced decrease in Sclerostin amount"

June 6, 2017

Robert Mauck, Mary Black Ralston Professor for Education and Research in Orthopaedic Surgery, "Mechanistic insight into renovations and relocations: from single cells to systems"

April 11, 2017

Sarah Gullbrand, Postdoctoral Fellow, Smith and Mauck Labs, "Stem cell and hydrogel-based therapeutics for intervertebral disc regeneration"

April 11, 2017

Bhavana Mohanraj, Graduate Student, Mauck and Dodge Labs, "High Throughput and Mechano-Active Platforms to Promote Cartilage Regeneration and Repair"

February 14, 2017

Julianne Heugel, Senior Researcher, Soslowsky Lab, "Pre-Clinical Rotator Cuff Study: Effects of PEMF on Rotator Cuff Repair in a Rodent Model"

February 14, 2017

Haitao Wang, Senior Researcher Investigator, Kaplan/Shore Lab, "Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling Pathway"


Seminars 2016

December 6, 2016

Brian Cosgrove, Graduate Student, Mauck Lab, "N-Cadherin adhesive interactions modulate ECM mechanosensing and fate commitment of mesenchymal stem cells"

October 11, 2016

Cori Riggin, Graduate Student, Soslowsky Lab, "Augmentation of Vascular Response in the Rat Achilles Tendon after Injury"

October 11, 2016

Chantel de Bakker, Graduate Student, Liu Lab, "Structural Adaptations of the Maternal Skeleton in Response to Reproduction and Lactation"

August 16, 2016

Wei Tong, Graduate Student, Qin Lab, "Dynamic vessel and bone formation: a coupled journey"

August 16, 2016

Claire McLeod, Graduate Student, Mauck Lab, "Differentiating Stem Cells Exhibit Molecular and Microenvironmental Heterogeneity"

May 10, 2016

Elisia Tichy, Postdoctoral Fellow, Mourkioti Lab, "Stem cell regulation in chronic muscle injuries"

April 12, 2016

Girish Ramaswamy, Postdoctoral Fellow, Shore Lab, "Gs-alpha Impacts Bone Quality by Regulating Osteoclast Activity During Bone Remodeling"

April 12, 2016

Sun Peck, Postdoctoral Fellow, Smith Lab, "Elucidating the Molecular Mechanisms Behind Failed Bone Formation in Mucopolysaccharidosis VII"

February 2, 2016

Ben Freedman, Graduate Student, Soslowsky Lab, "Surgical treatment and return to activity timing affects Achilles tendon healing in rodents"

February 2, 2016

Michael Convente, Graduate Student, Shore Lab, "The Immunologic Contribution to Heterotopic Ossification Disorders - Insights from FOP"


Center for Molecular Biology Laboratory Seminars

All seminars are scheduled at the McKay Orthopaedic Research Laboratory Library 426A Stemmler Hall at 12:00 noon, unless otherwise noted. This seminar series is sponsored by the Center for Research in FOP and Related Disorders at the University of Pennsylvania. *Some speakers were supported through the Department of Genetics and the Department of Cell and Developmental Biology seminar program. Links to additional relevant seminars can be found at:

Penn Center for Musculoskeletal Disorders Seminars

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