Seminars

Orthopaedic Research Laboratory Departmental Seminars

McKay Orthopaedic Research Laboratory Seminars

Seminars 2019

November 25, 2019

Ernestina Schipani, MD, PhD, University of Michigan, "The Hypoxia-driven pathway and reprogramming of metabolism in skeletal development"

July 10, 2019

Rachel Miller, PhD, Rush University, "Investigating Mechanosensitive Ion Channel Signaling in Osteoarthritis"

May 23, 2019

Elazar Zelzer, PhD, Weizmann Institute of Science, "The  importance  of  cross-tissue  regulation  for musculoskeletal  assembly  and  function"

May 21, 2019

Anne-Marie Malfait, MD, PhD, Rush Medical College, "Joint pathology and neuroplasticity in the development of osteoarthritis pain"

April 12, 2019

Jay Jiang, PhD, University of Maryland, "The Role of CCN in Tendon, Cartilage and Bone Development"

March 28, 2019

Wei Hsu, PhD, University of Rochester, "Skeletal stem cells: from development & disease to regenerative medicine"

January 10, 2019

L. Scott Levin, MD, FACS, University of Pennsylvania, "Value and Import of Research in Academic Medicine"

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Seminars 2016-18

December 17, 2018

Tamara Alliston, PhD, University of California, San Francisco, "The Central Role of Osteocytes in Skeletal and Systemic Homeostasis and Disease"

November 19, 2018

Karl Lewis, PhD, Indiana University School of Medicine, "The development of intravital imaging techniques for the study of osteocyte calcium signaling in vivo"

April 26, 2018

Jesús Delgado-Calle, PhD, Indiana University, "Osteocytes as Targets for the Treatment of Multiple Myeloma"

January 25, 2018

Teresita Bellido, PhD, Indiana University, "Osteocyte-regulated pathways in bone: from biology to pathophysiology"

December 18, 2017

Elise Morgan, PhD, Boston University, "Weak links aren’t always weak: The mechanics of spine fractures"

March 13, 2017

Denitsa Docheva, PhD, University of Regensburg Medical Centre, "Stem Cells: Players in tendon physiology, disease and repair"

June 14, 2016

Lidan You, PhD, University of Toronto, "Bone cell cross talk under mechanical loading"

June 13, 2016

Ryan Tomlinson, PhD, Johns Hopkins University, "The Role of Sensory Nerves in Bone"

May 2, 2016

Kyu-Sang Joeng, PhD, Baylor College of Medicine, "WNT1-related Osteogenesis Imperfecta: Pathogenic mechanism and potential therapeutics"

April 25, 2016

Kurt Hankenson, DVM, PhD, Laboratory for Comparative Orthopedic Research, "Translating basic science discoveries to regenerative therapeutics: Notch signaling regulation of bone formation"

March 14, 2016

Michael Albro, PhD, Imperial College London, "Mechanical Regulation of Growth Factors in Native and Engineered Tissues of the Synovial Joints"

January 21, 2016

Eve Donnelly, PhD, Cornell University, "Multiscale Mechanical and Compositional Characterization of Bone Tissue in Health and Disease"

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Seminars 2013-15

November 23, 2015

Louis DeFrate, PhD, Duke University "In Vivo Joint Function and Dysfunction: Implications for Early Onset Osteoarthritis"

September 10, 2015

Nat Dyment, PhD, UConn Health "Defining the tendon lineage to improve tissue engineering strategies"

May 20, 2014

Sarah E. Linley, PhD candidate, Rensselaer Polytechnic Institute, "Enhancing Transport into the Intervertebral Disc In Vivo: The Effects of Loading Induced Convection and Alterations to the Vertebral Endplate Vasculature"

February 13, 2014

Shashank Nawathe, PhD candidate, University of California, Berkeley, "Micromechanics of the Human Proximal Femur"

February 6, 2014

Jennifer L. Puetzer, PhD candidate, Cornell University, "Development of Self-Organizing Tissue Engineered Menisci"

January 16, 2014

Karin Grävare Silbernagel PT, ATC, PhD, University of the Sciences, "Exercise as Treatment for Achilles Tendon Injury: A Clinical Research Perspective"

June 24, 2013

Foteini Mourkioti, PhD, Stanford University, "Stem Cells, Short Telomeres and Oxidative Stress in Regeneration: Insights from a New Musculoskeletal Disease Model"

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Seminars 2010-2001

December 20, 2012

John T. Connelly, Ph.D., Blizard Institute, "Insights into the biophysical regulation of epidermal cell fate using engineered micro-environments"

December 10, 2012    

Nadeen O. Chahine, Ph.D., Hofstra North Shore LIJ, "Identifying Mechanisms of Injury and Repair in the Intervertebral Disc"

December 4, 2012

Kimberly Cooper, Ph.D., Harvard Medical School, "Development and Evolution of Form in the Vertebrate Limb"

November 29, 2012

Frank Beier, Ph.D., The University of Western Ontario, "Signaling Pathways in Skeletal Development and Osteoarthritis"

October 24, 2012

Joel D. Boerckel, Ph.D., Cleveland Clinic, "Mechanical and Biological Regulation of Tissue Regeneration"

May 9, 2012

Christian Gerber, Prof. Dr. med., University of Zurich - Uniklinik Balgrist, "The Effect of Tendon Tearing on the Rotator Cuff Muscles"

December 5, 2011

Jenna Galloway, PhD, Harvard Medical School, "Regulation of Progenitor Cell Specification and Patterning in the Musculoskeletal System"

October 21, 2011

Stavros Thomopoulos, PhD, Washington University, "Structure, Biomechanics, and Mechanobiology in the Attachment of Tendon to Bone"

October 20, 2011

James L. Cook, PhD, University of Missouri, "Translational Modeling of Joint Disease"

May 26, 2011

Leesa Galatz, MD, Washington University School of Medicine, "Rotator Cuff Muscle Degeneration

April 25, 2011

Jean B. Regard, PhD, National Institutes of Health, "G Protein Signaling in Skeletal Development and Disease"

October 25, 2010

Ryan M. Porter, PhD, Harvard Medical School, "Proinflammatory Challenge to Chondrogenesis in situ"

July 13, 2010

Xiaowei Sherry Liu, PhD, Columbia University Medical Center, "Clinical Imaging and the Mechanical Modeling of Bone"

June 3, 2010

Evan L. Flatow, MD, The Mount Sinai School of Medicine, "Understanding Tendon Fatigue Damage"

June 1, 2010

Michael L. Sohaskey, PhD, University of California, "Novel Molecular Pathways in Skeletal Development, Homeostasis and Repair"

May 6, 2010

Frank Beier, PhD, University of Western Ontario, "TGFa Signaling in Cartilage Development and Osteoarthritis"

April 29, 2010

Joseph M. Wallace, PhD, University of Michigan, "Quantitative In Situ Ultrastructural Analysis of Type I Collagen-Based Tissues in Health and Disease"

April 8, 2010

Mark Buckley, Cornell University, "Mapping the Functional Properties of Articular Cartilage under Shear Loading"

September 9, 2009

Gil Navon, PhD, Tel Aviv University, "New MRI Techniques for the Study of Connective Tissues"

July 14, 2009

Johnna Temenoff, PhD, Georgia Institute of Technology, "Biomaterial-Based Approaches to Engineering the Ligament-Bone Interface"

June 29, 2009

Valerie Siclari, PhD, University of Virginia, "The Role of Adrenomedullin in Breast Cancer Bone Metastasis"

May 7, 2009

Martin I. Boyer, MD, Washington University, "Flexor Tendon Biology and Biomechanics"

April 30, 2009

Christopher Harner, MD, University of Pittsburgh, "New Developments in the Sports Medicine Biomechanics Lab at the University of Pittsburgh"

December 11, 2008

Jon J.P. Warner, MD, Massachusetts General Hospital and Brigham and Women's Hospitals and Harvard Medical School, "In Vivo Shoulder Kinematics: What Lies Beneath"

October 28, 2008

Daniel Cortes, West Virginia University, "Guided Waves and Their Trends"

October 21, 2008

Arturo Valentin, Texas A & M University, "Complementary Vasoactivity and Matrix Remodeling: Theoretical Foundations and Predicted Trends"

September 24, 2008

Bridget Deasy, Ph.D., University of Pittsburgh School of Medicine, "Sex-differences in Stem Cells and Muscle Repair"

July 17, 2008

Mark Randolph, M.A.S., Harvard Medical School, Massachusetts General Hospital, "Engineered Cartilage to Integrate and Repair Meniscal Tears"

June 16, 2008

Kurt Spindler, Ph.D., Vanderbilt University, "Translational Animal Models for Clinical Outcomes"

April 16, 2008

Ling Qin, Ph.D., Robert Wood Johnson Medical School, "EGF Receptor Signaling in Bone Metabolism and Cancer Bone Metastasis"

February 25, 2008

Kingston Mak, Ph.D., National Human Genome Research Institute/NIH, "Roles of Hedgehog Signaling in Postnatal Skeletal System"

February 14, 2008

David Komatsu, Ph.D., Indiana University/Eli Lilly, "Impairing and Improving Bone Regeneration: Genetic, Mechanical and Pharmacological Approaches"

January 10, 2008

Regis O'Keefe, M.D., Ph.D., University of Rochester Medical Center, "The Pathogenesis of Osteoarthritis: Molecular Targets for Potential Therapeutics"

May 24, 2007

Richard Gelberman, M.D., Washington University, "Advances in Tendon Repair"

February 8, 2007

Kurt Spindler, M.D., Vanderbilt University, "Intraarticular Healing of the ACL"

March 7, 2006

Rocky Tuan, Ph.D., NIAMS/NIH, "Developmental Paradigms for Cell-Based Tissue Engineering"

February 21, 2006

X. Edward Guo, Ph.D., Columbia University, "Mechanobiology of Bone"

December 13, 2005

Jeffrey Lotz, Ph.D., University of California, San Francisco, "Biomechanics of Back Pain"

November 29, 2005

Bob Pignolo, M.D., Ph.D., "Lab poster session"

November 8, 2005

David Birk, Ph.D., Thomas Jefferson University, "Development of Tendon Extracellular Matrix Structure and Function: Regulation by Collagen and Proteoglycan Interactions"

September 15, 2005

Steven Arnoczky, Ph.D., "Mechanotransduction in Tendon Cells: Implications for Rehabilitation and Overuse Injuries"

September 6, 2005

Rob Mauck, Ph.D., "Lab poster session"

July 26, 2005

Richard Lieber, Ph.D., University of California, San Diego, "Intraoperative Laser Diffraction Studies of Human Muscle in Hand Surgery

May 17, 2005

Jeff Weiss, Ph.D., University of Utah, "Angiogenesis and the Extracellular Matrix"

April 19, 2005

Kai-Nan An, Ph.D., Mayo Clinic, "Tendon Biomechanics and Clinical Applications"

March 8, 2005

Louis Soslowsky, Ph.D., "Lab poster session"

February 15, 2005

Matthew Silva, Ph.D., Washington University, "The SAMP6 Mouse Model of Senile Osteoporosis: Biomechanics and Mechanobiology"

November 30, 2004

Carl Brighton, M.D., Ph.D. and Chris Clark, Ph.D., "Lab poster session"

October 21, 2004

Don Chaffin, Ph.D., University of Michigan, "Human Motions at Work and Their Biomechanical Implications"

October 12, 2004

Katrin McGowen, Ph.D., University of Pennsylvania, "Obstacles to Good Time Management"

September 21, 2004

Dawn Elliott, Ph.D., "Lab poster session"

June 24, 2004

Timothy Baradet, Ph.D. "Orthopaedic Histology at The McKay Laboratory"

May 3, 2004

Jay Humphery, Ph.D., Texas A&M University, "Biomechanics of Arterila Growth and Remodeling"

April 20, 2004

Louis Soslowsky, Ph.D., "Lab poster session"

February 17, 2004

Fred Kaplan, M.D., Eileen Shore, Ph.D., "Lab poster session"

January 19, 2004

Rob Mauck, Ph.D., Columbia University, "Functional Tissue Engineering of Articular Cartilage: Challenges and Opportunities"

December 16, 2003

James Goh, Ph.D., National University of Singapore, "Tissue Engineering Approaches to Tendon and Ligament Repair and Regeneration"

September 16, 2003

Richard Brand M.D., Editor, Clinical Orthopaedics and Related Research, "How to write a Research Paper"

May 6, 2003

Steve Nicoll, Ph.D., "Regulating Cellular Phenotype for Connective Tissue Engineering Applications"

April 10, 2003

Rob Mauck, Ph.D., Columbia University, "Functional Approaches to Articular Cartilage Tissue Engineering and Repair"

February 20, 2003

Jason A. Burdick, Ph.D., Massachusetts Institute of Technology, "Utilizing Photopolymerization in the Field of Tissue Engineering: Specific Applications in Bone Regeneration"

January 7, 2003

Donna Dean, Ph.D., Deputy Director, NIBIB, NIH, "Exciting New Research Funding Opportunities in Bioengineering and Imaging"

December 19, 2002

Scott Boden, M.D., Emory University, "Gene Therapy for Spine Disorders"

December 9, 2002

Joe Iannotti, M.D., Ph.D., Cleveland Clinic Foundation, "Glenohumeral Kinematics and Prosthetic Design"

October 7, 2002

Lisa Belincampi, Ph.D, Orthovita Inc., "Biomedical Engineering and Orthopaedics in Industry"

April 30, 2002

Vivian Cheung, M.D., Assistant Professor Children's Hospital of Philadelphia, "Expression Phenotyping Using cDNA Microarrays"

April 11, 2002

Dr. Barrack, M.D., Faculty Tulane University, "Implant Bearing Surfaces"

March 21, 2002

Andy Putnam Ph.D., University of Michigan, "Materials for Tissue Engineering"

February 5, 2002

Prasad Shastri, Ph.D., CHOP, "Tissue Engineering Fundamentals for Connective Tissue Repair"

November 11, 2001

John Emery, Ph.D., GlaxoSmithKline, "Characterization of BMPs, receptors, and signalling intermediates during human mesenchymal stem cell differentiation"

October 23, 2001

Haidi Zhang, M.D., Ph.D., Research Associate, Rheumatology, "Development of molecular synovectomy using 'gene scalpels' for the treatment of rheumatoid arthritis and other arthropathies"

September 25, 2001

David L. Diefenderfer, V.M.D., Ph.D., University of Pennsylvania, "BMP-Induced Osteogenesis in Human Marrow Stromal Cells"

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McKay Young Investigator Seminars

This seminar series was designed to highlight the research and achievements of up and coming young scientists in the McKay Orthopaedic Research Lab. The goal of this seminar series is to provide a forum for senior graduate students, post docs and research associates who are poised to embark on the next stage of their careers to present their work to the department, and to stimulate discussion and collaboration between individual McKay labs.

Seminars 2019

October 8, 2019

Chenghao Zhang PhD, Postdoctoral Fellow, Smith/Malhotra Lab "Stem cell-based intervertebral disc regeneration: progress and challenges in a preclinical large animal model"

October 8, 2019

Ryan Leiphart BS, PhD Student, Soslowsky Lab "Collagen V deficiency during healing mitigates the quasi-static mechanical deficits of injured tendons"

October 8, 2019

Elisia Tichy PhD, Postdoctoral Fellow, Mourkioti Lab "Telomere length regulation of muscle stem cells in chronic injuries"

August 13, 2019

Timur Kamalitdinov, PhD Student, Dyment Lab "Alpha smooth muscle actin-expressing progenitors produce zonal insertion sites in tendon-to-bone repair"

August 13, 2019

Wenzheng Wang MD, Postdoctoral Researcher, Liu Lab "Dynamics of Modeling- and Remodeling-Based Bone Formation in response to intermittent parathyroid hormone"

August 13, 2019

Niambi Brewer, PhD Student, Shore Lab "Gnas inactivation alters adipose tissue properties during progression to heterotopic ossification”

June 18, 2019

Yulong Wei MD, Visiting Graduate Student, Qin Lab "The Regulatory Role of EGFR Signaling in Adult Cartilage Homeostasis and Osteoarthritis"

June 18, 2019

Jay Patel PhD, Postdoctoral Fellow, Mauck Lab ""Biomaterial-Mediated Reprogramming of Cartilage Defects to Localize and Direct Stem Cell Therapies"

April 23, 2019

Tonia Tsinman BS, PhD Student, Mauck/Dyment Labs "Temporal evolution of cell phenotype and biophysical cues in the developing murine meniscus microenvironment"

April 23, 2019

Ana Paula Peredo BS, PhD Student, Mauck/Dodge Labs "Mechanically-Activated Microcapsules for On-Demand Drug Delivery"

April 23, 2019

Joseph Collins BS, PhD Student, Boerckel Lab "YAP and TAZ regulate the formation of the primary ossification center in embryonic limbs"

February 26, 2019

Robyn Allen BA, VMD/PhD Student, Mullins/Shore Labs "BMP-Smad1/5 signaling interactions in a zebrafish model of FOP"

February 26, 2019

Chris Kegelman BS, PhD Student, Boerckel Lab "YAP and TAZ mediate osteocyte perilacunar/canalicular remodeling"

February 26, 2019

Leilei Zhong PhD, Postdoctoral Fellow, Qin Lab "Deciphering the in vivo heterogeneity of mouse bone marrow mesenchymal progenitors at single cell resolution"

 

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Seminars 2018

December 4, 2018

Cheng Zhou PhD, Postdoctoral Fellow, Scanzello/Dodge Labs "Elucidating the role of inflammatory cells in osteoarthritis"

December 4, 2018

Danielle Rux PhD, Postdoctoral Fellow, Pacifici Lab, "Understanding Roles for the Primary Cilium During
Postnatal Articular Cartilage Morphogenesis"

October 9, 2018

Alexandra Stanley, PhD Student Mourkioti/Shore Labs, "Aberrant muscle tissue repair by mutant ACVR1/ALK2 FOP progenitor cells – implications for heterotopic ossification"

October 9, 2018

Edward Bonnevie PhD, Postdoctoral Fellow Mauck Lab, "Disruption of boundary constraints activates aberrant mechano-sensing in injured intervertebral discs"

August 14, 2018

Hongbo Zhao, Visiting PhD Student, Liu Lab, "Cyclic and Alternating Parathyroid Hormone (PTH) and Alendronate Treatment Regimens Further Improve Bone Microarchitecture and Strength Beyond Daily and Cyclic PTH Regimens"

August 14, 2018

Catherine Bautista, Graduate Student, Dyment Lab, "Identifying a Novel Subset of Tendon Cells"

June 5, 2018

Will Towler, Graduate Student, Shore Lab, "Regulation of phalangeal joint development by ACVR1 in fibrodysplasia ossificans progressiva"

June 5, 2018

Su Chin Heo, Research Associate, Mauck Lab, "Nuclear Softening Expedites Interstitial Cell Migration in Dense Connective Tissues"

April 10, 2018

Zak Beach, Graduate Student, Soslowsky Lab, "The Surprising Roles of Decorin and Biglycan during Tendon Homeostasis"

April 10, 2018

Luqiang Wang, Graduate Student, Qin Lab, "Prior focal radiation causes atrophic nonunion fracture in mice"

February 27, 2018

Devon Mason, Graduate Student, Boerckel Lab, "Persistent cell motility requires transcriptional feedback of cytoskeletal-focal adhesion equilibrium by YAP/TAZ"

February 27, 2018

Justin Bendigo, Graduate Student, Smith Lab, "Preconditioning of mesenchymal stem cells to enhance survival and extracellular matrix production in the intervertebral disc"

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Seminars 2017

October 10, 2017

Yihan Li, Graduate Student, Liu Lab, "Effects of Reproduction and Lactation on Maternal Bone Mechano-Sensitivity"

October 10, 2017

Maryam Sharifi-Sanjani, Postdoctoral Fellow, Mourkioti Lab, "Telomere Dynamics in Cardiac Muscle"

August 15, 2017

Salin Chakkalakal, Senior Research Investigator, Shore Lab, "Development and application of novel FOP mouse models for investigating heterotopic ossification and drug development"

August 15, 2017

Cheng Zhou, Postdoctoral Fellow, Dodge Lab, "Enhanced phagocytic capacity endows chondrogenic progenitor cells with a novel scavenger function within injured cartilage"

June 6, 2017

Xiaoyuan Ma, Postdoctoral Fellow, Qin Lab, "Subchondral bone plate sclerosis during late osteoarthritis is mediated by loading-induced decrease in Sclerostin amount"

June 6, 2017

Robert Mauck, Mary Black Ralston Professor for Education and Research in Orthopaedic Surgery, "Mechanistic insight into renovations and relocations: from single cells to systems"

April 11, 2017

Sarah Gullbrand, Postdoctoral Fellow, Smith and Mauck Labs, "Stem cell and hydrogel-based therapeutics for intervertebral disc regeneration"

April 11, 2017

Bhavana Mohanraj, Graduate Student, Mauck and Dodge Labs, "High Throughput and Mechano-Active Platforms to Promote Cartilage Regeneration and Repair"

February 14, 2017

Julianne Heugel, Senior Researcher, Soslowsky Lab, "Pre-Clinical Rotator Cuff Study: Effects of PEMF on Rotator Cuff Repair in a Rodent Model"

February 14, 2017

Haitao Wang, Senior Researcher Investigator, Kaplan/Shore Lab, "Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling Pathway"

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Seminars 2016

December 6, 2016

Brian Cosgrove, Graduate Student, Mauck Lab, "N-Cadherin adhesive interactions modulate ECM mechanosensing and fate commitment of mesenchymal stem cells"

October 11, 2016

Cori Riggin, Graduate Student, Soslowsky Lab, "Augmentation of Vascular Response in the Rat Achilles Tendon after Injury"

October 11, 2016

Chantel de Bakker, Graduate Student, Liu Lab, "Structural Adaptations of the Maternal Skeleton in Response to Reproduction and Lactation"

August 16, 2016

Wei Tong, Graduate Student, Qin Lab, "Dynamic vessel and bone formation: a coupled journey"

August 16, 2016

Claire McLeod, Graduate Student, Mauck Lab, "Differentiating Stem Cells Exhibit Molecular and Microenvironmental Heterogeneity"

May 10, 2016

Elisia Tichy, Postdoctoral Fellow, Mourkioti Lab, "Stem cell regulation in chronic muscle injuries"

April 12, 2016

Girish Ramaswamy, Postdoctoral Fellow, Shore Lab, "Gs-alpha Impacts Bone Quality by Regulating Osteoclast Activity During Bone Remodeling"

April 12, 2016

Sun Peck, Postdoctoral Fellow, Smith Lab, "Elucidating the Molecular Mechanisms Behind Failed Bone Formation in Mucopolysaccharidosis VII"

February 2, 2016

Ben Freedman, Graduate Student, Soslowsky Lab, "Surgical treatment and return to activity timing affects Achilles tendon healing in rodents"

February 2, 2016

Michael Convente, Graduate Student, Shore Lab, "The Immunologic Contribution to Heterotopic Ossification Disorders - Insights from FOP"

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Penn Center for Musculoskeletal Disorders Seminars

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Orthopaedic Research Club (ORC) Seminars

ORC is a platform for promoting cooperative interaction among investigators who engage in musculoskeletal research at the University of Pennsylvania and neighboring institutes.

Seminars 2018-19

December 11, 2019

Warren Grayson, PhD, Johns Hopkins University, "Functional Regeneration of Craniofacial Bone and Skeletal Muscle"

October 30, 2019

Sarah E. Catheline, PhD, Children's Hospital of Philadelphia, "Sustained IKKβ activation in postnatal chondrocytes accelerates the onset of age-associated murine osteoarthritis"

October 30, 2019

Ranjan Kc, PhD, Children's Hospital of Philadelphia, "Maintenance of growth plate and articular chondrocyte phenotype by SOX9"

September 25, 2019

George Dodge, PhD, University of Pennsylvania, "New Approaches to Therapeutic Discovery & Delivery"

August 28, 2019

Riccado Gottardi, PhD, Children's Hospital of Philadelphia, "Loads and signaling for cartilage regeneration"

July 31, 2019

Megan Killian, PhD, University of Delaware, "Growth and remodeling of musculoskeletal interfaces"

May 29, 2019

Josh Baxter, PhD, University of Pennsylvania, "Applied biomechanics to improve treatment options for Achilles tendon ruptures"

April 24, 2019

Fanxin Long, PhD, Children's Hospital of Philadelphia, "Growth factor and metabolic regulation of bone formation"

March 27, 2019

Mary Barbe, PhD, Temple University, "Blocking Substance P signaling reduces tissue fibrosis and improves sensorimotor declines in a rat model of overuse injury"

February 27, 2019

Michael Hast, PhD, University of Pennsylvania, "Macroscopic In Vitro, In Silico, and In Vivo Models of Shoulder Reconstructions"

January 23, 2019

Veronique Lefebvre, PhD, Children’s Hospital of Philadelphia, "Deciphering the molecular basis of SOXopathies, developmental
syndromes due to mutations affecting SOX transcription factor activities"

November 28, 2018

Xin Li, PhD, New York University, "Altered bone metabolism by hyperglycemia: a new function of an old metabolite"

October 31, 2018

Jormay Lim, PhD, University of Pennsylvania, "Primary cilia are essential for cell alignment and polarity during bone development through regulating Ceramide-PKCz apicobasal polarity signaling"

Christina Mundy, PhD, Children’s Hospital of Philadelphia, "Potential therapeutic targets to reduce osteochondromas in patients with Hereditary Multiple Exostoses"

October 4, 2018

Brya Matthews, PhD, University of Auckland, "Identification of periosteal progenitors involved in bone healing"

September 26, 2018

Anh Le, DDS, PhD, Penn Dental Medicine, "Large Gap Peripheral Nerve Regeneration with Orofacial Stem Cells Based Nerve Guidance Conduits"

August 29, 2018

David Paglia, PhD, Rutgers University, "Insulin-mimetic salt induces of bone formation and inhibits osteoclast differentiation and fusion to restore cortical porosity in a type I diabetic-induced osteolysis rat model"

June 19, 2018

Andrew Kuntz, MD, University of Pennsylvania, "Rotator Cuff Repair - From Bench to Bedside, Challenges and Opportunities"

May 30, 2018

Noriaki Ono, DDS, PhD, University of Michigan School of Dentistry, "Skeletal/mesenchymal stem cells: how much do we know about them? A lineage-tracing perspective"

April 25, 2018

Joel Boerckel, PhD, University of Pennsylvania, "Forceful feedback: mechanosensation in cell motility and morphogenesis"

March 28, 2018

Christopher Price, PhD, University of Delaware, "New Therapeutic Strategies for Preventing Cartilage Degeneration and Post-Traumatic Osteoarthritis"

February 21, 2018

Maurizio Pacifici, PhD, Children’s Hospital of Philadelphia, "Morphogenesis of articular cartilage: implications for repair strategies"

January 17, 2018

Scott Levin, MD, FACS, University of Pennsylvania, "Hand transplantation: current challenges and future prospects"

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Seminars 2016-17

November 29, 2017

Nancy Pleshko, PhD, Temple University, "Novel Spectroscopic Imaging Tools for Assessment of Musculoskeletal Tissues"

October 25, 2017

Ryan Tomlinson, PhD, Thomas Jefferson University, "Inflammatory Signals in Stress Fracture Risk and Repair"

September 28, 2017

Danielle Rux, PhD, Children’s Hospital of Philadelphia, "Hox Genes in the Adult Skeleton: Patterning Cues Beyond Embryonic Development"

September 28, 2017

Xia Zhao, University of Pennsylvania, "In vivo Bone Quality Assessment by Phosphorus and Proton MRI"

August 30, 2017

Michael Levine, MD, MACE, FAAP, FACP, Children’s Hospital of Philadelphia, "Vitamin D deficiency in the 21st Century: New Insights into an Old Problem"

June 28, 2017

Mei Wan, PhD, Johns Hopkins University School of Medicine, "Mechanisms of PTH Bone Anabolic Action - New Perspectives On An Old Topic"

May 24, 2017

Li-Hsin (Leo) Han, PhD, Drexel University, College of Engineering, "Micro-noodles" for Cartilage Repair: A Strategy to Achieve Tunable Cell shape, Mechanosensing, and ECM organization in 3-D"

April 14, 2017

Li Zeng, PhD, Tufts University School of Medicine, "Regulators of cartilage development and maintenance"

March 28, 2017

Louis Soslowsky, PhD, University of Pennsylvania, "Tendon Healing in a Rotator Cuff Animal Model"

February 22, 2017

Noreen Hickok, PhD, Thomas Jefferson University, "Infections in synovial fluid: new challenges"

January 24, 2017

Nat Dyment, PhD, University of Pennsylvania, "Defining the lineage of tendon and ligament cells"

December 7, 2016

Shuying Yang, PhD, University of Pennsylvania, School of Dental Medicine, "Mechanism of Ciliary Intraflagellar Transport Protein in Bone Formation"

November 2, 2016

Simon Tang, PhD, Washington University in St. Louis, "Multiscale Mechanisms of Low Back Pain"

September 28, 2016

Chamith Rajapske, PhD, University of Pennsylvania, "Recent Developments in Imaging Techniques for Evaluation of Bone Disorders"

July 27, 2016

Harvey Smith, MD, University of Pennsylvania, "Applied MRI Quantitative Imaging Sequences and Tissue Engineering for the Treatment of Intervertebral Disc Degeneration"

June 6, 2016

Chi-der Chen, PhD, University of Pennsylvania, School of Dental Medicine, "Mesenchymal stem cell transplantation identifies miR151-5p as a therapeutic target for systemic sclerosis"

June 6, 2016

Satoru Otsuru, PhD, Nationwide Children's Hospital, "Understanding the mechanism of bone growth after MSC infusion"

May 25, 2016

Carla Scanzello, MD, PhD, University of Pennsylvania, "Inflammatory pathway activation in osteoarthritis: insights from patients and animal models"

April 27, 2016

Andrzej Fertala, PhD, Thomas Jefferson University, "Prevention of the Post-traumatic Fibrotic Response in Joints"

March 23, 2016

Herb Sun, PhD, Albert Einstein College of Medicine, "The role of CITED2 in cartilage and tendon: A basic study searching for translation"

February 24, 2016

Eiki Koyama, DDs, PhD, Children's Hospital of Philadelphia, "The roles of Indian hedgehog in temporo-mandibular joint (TMJ) development and postnatal function"

January 27, 2016

Jason Burdick, PhD, University of Pennsylvania, "Engineering Hydrogels for Cartilage Repair"

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Seminars 2014-15

Dec 2, 2015

Yeijia Zhang, PhD, University of Pennsylvania, "Intervertebral disc degeneration and repair"

October 28, 2015

Foteini Mourkioti, PhD, University of Pennsylvania, "Regenerative stem cell therapies to restore diseased skeletal muscles"

September 23, 2015

Yu Usami, Children's Hospital of Philadelphia, "Contribution of Wnt/b-catenin-Responsive Cells to Articular and Growth Plate Cartilage Growth"

September 23, 2015

Jason Ashley, PhD, University of Pennsylvania, "Modulation of osteoclast function: finding a niche in Notch signaling"

August 26, 2015

Samir Mehta, MD, University of Pennsylvania, "Trying to Make Sense of it All:The Regulation of Fracture Healing in a Trauma Setting"

July 29, 2015

Lin Han, PhD, Drexel University, "Nanomechanics: A Novel Interdisciplinary Tool to Uncover the Pathogenesis of Osteoarthritis"

June 24, 2015

Abhishek Chandra, PhD, University of Pennsylvania, "Radiotherapy Induced Bone Damage: Basics to Therapeutics"

June 24, 2015

Chantal de Bakker, University of Pennsylvania, "Effects of Pregnancy, Lactation, and Weaning on Maternal Bone Quality"

May 27, 2015

Sunday Akintoye, BDS, DDS, MS, University of Pennsylvania, School of Dental Medicine, " Skeletal Stem Cells: is the jaw bone connected to the hip bone?"

April 22, 2015

Lacklan Smith, PhD, University of Pennsylvania, "Unraveling the Etiology of Spine Disease in Mucopolysaccharidosis Disorders"

March 18, 2015

Mindy George-Weinstein, PhD, Cooper Medical School of Rowan University, "Roles of Myo/Nog Cells in Embryogenesis, Wound Healing and Neuroprotection"

Februay 25, 2015

Liyun Wang, PhD, University of Delaware, "Osteocyte’s hairy pericellular matrix in mechanosensing"

December 10, 2014    

Songtao Shi, DDS, MS, PhD, University of Pennsylvania, School of Dental Medicine, "Mesenchymal stem cells: from clinics to bench-top and back"

October 22, 2014

Federica Sgariglia, PhD, Children’s Hospital of Philadelphia, "Previously unsuspected defects in the cranial base of a mouse model of Hereditary Multiple Exostoses"

October 22, 2014

Brianne Connizzo, University of Pennsylvania, "In situ fibril stretch and sliding is location-dependent in mouse supraspinatus tendons"

September 24, 2014 

X. Lucas Lu, PhD, University of Delaware, "Prevention and Treatment of Post-traumatic Osteoarthritis"

August 13, 2014  

Jaimo Ahn, MD, PhD, FACS, University of Pennsylvania, "Enhancing fracture healing: lessons from our rodent friends"

June 25, 2014 

Girish Ramaswamy, PhD, University of Pennsylvania, "GNAS inactivation in Progressive Osseous Heteroplasia (POH) and skeletal development"

June 25, 2014 

Spencer Szczesny, University of Pennsylvania, "GNAS inactivation in Progressive Osseous Heteroplasia (POH) and skeletal development"

May 28, 2014  

Masahiro Iwamoto, PhD, DDS, Children's Hospital of Philadelphia, "Specification and maintenance of permanent articular cartilage"

April 30, 2014    

Elisabeth Barton, PhD, University of Pennsylvania, School of Dental Medicine, "Forces and factors from muscle that modulate bone"

March 26, 2014  

Dana Graves, DDS, DMSc, University of Pennsylvania, School of Dental Medicine, "Osteoblastic cells regulate the response of bone to inflammation"

Februay 26, 2014  

Theresa Freeman, PhD, Thomas Jefferson University, "Regeneration - ASK1, can it provide some answers?"

January 15, 2014    

Robert Mauck, PhD, University of Pennsylvania, "Material and Mechanobiologic Considerations for Engineering Dense Connective Tissues"

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Institute for Regenerative Medicine (IRM) Advances in Musculoskeletal Regeneration Seminars

Seminars 2019-2020

October 24, 2019

Tim Woodfield, PhD, University of Otago, "Designing Bioink and Bioreactor Platforms for Musculoskeletal Regenerative Medicine"

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Seminars 2018-2019

April 30, 2019

Michael Longaker, MD, MBA, FACS, Stanford University School of Medicine and Hagey Laboratory for Pediatric Regenerative Medicine, "Skeletal Stem Cells"

March 12, 2019

Johnna Temenoff, PhD, Georgia Institute of Technology and Emory University, "Biomaterials based strategies for repair of rotator cuff tendon and muscle"

February 12, 2019

Karl Kadler, PhD, University of Manchester, UK, "Circadian clock regulation of collagen homeostasis"

January 18, 2019

Pura Munoz-Canoves, PhD, Universitat Pompeu Fabra and ICREA, "Understanding muscle stem cell regenerative decline with aging"

December 7, 2018

Robert Krauss, PhD, Mount Sinai, "Niche regulation of muscle stem cell quiescence and activation"

November 9, 2018

Vittorio Sartorelli, MD, PhD, NIH/NIAMS, "Enhancing Expression by Enhancer RNAs"

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Seminars 2017-2018

May 8, 2018

Sara Wickström, MD, PhD, University of Helsinki, "Regulation of stem cell fate through niche-derived signals and mechanical forces"

April 24, 2018

Christopher Evans, PhD, Mayo Clinic, "Orthopedic Applications of Gene Therapy"

March 27, 2018

Eben Alsberg, PhD, Case Western Reserve University, "Modular inductive high-density cell culture systems for engineering complex tissues"

February 23, 2018

Nat Dyment, PhD, University of Pennsylvania, "Tenocytes, Tenoblasts, and Tenoclasts(?): Defining the Cell Types within Tendons"

February 23, 2018

Alex Hughes, PhD, University of Pennsylvania, "Testing the design rules of tissue curvature in development"

January 26, 2018

Bradley Olwin, PhD, University of Colorado, "How are Muscle Stem Cells Numbers Maintained?"

December 15, 2017

Ivo Kalajzic, PhD, University of Connecticut Health Center, "Identifying different Osteoprogenitors and Understanding Their Role in Bone Repair"

November 10, 2017

Jenna Galloway, PhD, Massachusetts General Hospital, Harvard Stem Cell Institute, "Insights into tendon developmental plasticity and regenerative biology using zebrafish and mice"

October 27, 2017

Srihari Sampath, MD, PhD, MPhil, Genomics Institute of the Novartis Research Foundation, "Skeletal muscle, from generation to regeneration"

September 12, 2017

Linda Sandell, PhD, Washington University, "Cartilage Repair and Osteoarthritis in Genetic Mouse Models"

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Seminars 2016-2017

June 7, 2017

Nidhi Bhutani, PhD, Stanford University, "Unlocking the Secrets of Young Cartilage to Enhance Regeneration and Repair"

May 9, 2017

Denis Guttridge, PhD, The Ohio State University College of Medicine, "NF-kB Signaling in Muscle Growth and Disease"

April 4, 2017

Laurie Goodrich, DVM, PhD, Colorado State University, College of Veterinary Medicine, "MSC’s and immunomodulation: are we moving closer to allogeneic use?"

February 17, 2017

Douglas Millay, PhD, University of Cincinnati, "Mechanisms and applications of muscle stem cell fusions"

January 20, 2017

April Craft, PhD, Boston Children's Hospital, "Potential Therapeutics Applications of Human Pluripotent Stem Cell-Derived Cartilage"

December 2, 2016

Steve Thomopoulos, PhD, Columbia University, "Biologically inspired solutions for attaching dissimilar materials"

November 4, 2016

Megan Killian, PhD, University of Delaware, "FGF signaling during development of musculoskeletal interfaces"

November 4, 2016

Evangelia Bellas, PhD, Temple University, "Adipose Tissue Engineering: The Big Picture"

October 12, 2016

Michael A. Rudnicki, OC, PhD, FRSC,University of Ottawa, "Molecular regulation of muscle stem cell function"

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Seminars 2015-2016

June 24, 2016

Andrew Brack, PhD, University of California, "Skeletal muscle stem cells: Regeneration and Aging"

May 17, 2016

Alessandra Sacco, PhD, Sanford Burnham Medical Research Institute, "Microenvironmental regulation of skeletal muscle stem cell function"

April 19, 2016

Charles Gershach, PhD, Duke University, "Genome and Epigenome Editing for Gene Therapy and Programming Cell Fate"

March 11, 2016

Eileen M. Shore, PhD, University of Pennsylvania and Maurizio Pacifici, PhD, Children’s Hospital of Philadelphia
"Heterotopic ossification, a disorder of mis-directed cell fates: pathogenesis and possible treatments"

January 29, 2016

Dennis E. Discher, PhD, University of Pennsylvania, "Matrix, Contractility, & Nucleus as a Polymeric Continuum: from striated muscle to immune therapy for solid tumors"

December 11, 2015

Penney Gilbert, PhD, University of Toronto, “Molecular consequences of biophysical changes in the muscle stem cell niche”

November 6, 2015

Fabio Rossi, MD, PhD, University of British Columbia, Vancouver, Canada, "Innate Immune Control of Fibrogenesis during Tissue Regeneration"

October 12, 2015

Robert E. Guldberg, PhD, Georga Institue of Technology, "The Perils and Promise of Regenerative Medicine: Emerging Trends"

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Center for Molecular Biology Laboratory Seminars

All seminars are scheduled at the McKay Orthopaedic Research Laboratory Library 426A Stemmler Hall at 12:00 noon, unless otherwise noted. This seminar series is sponsored by the Center for Research in FOP and Related Disorders at the University of Pennsylvania. *Some speakers were supported through the Department of Genetics and the Department of Cell and Developmental Biology seminar program. Links to additional relevant seminars can be found at: http://www.med.upenn.edu/genetics/seminars.shtml


 

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