Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Faculty

Lachlan James Smith

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Assistant Professor of Neurosurgery
Department: Neurosurgery

Contact information
McKay Orthopaedic Research Laboratory
111A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Office: 215-898-8653
Fax: 215-573-2133
Education:
B.E. (Mechatronic Engineering)
University of Adelaide, 2001.
Ph.D. (Pathology)
University of Adelaide, 2008.
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Description of Research Expertise

The focus of my research program is the pathophysiology and treatment of degenerative and developmental disorders affecting the spine, particularly those affecting the intervertebral discs and vertebral bones. The scope of our research includes basic mechanistic studies, translational studies in animal models, and clinical studies in human patients. We use cutting edge techniques in molecular biology, biochemistry and bioengineering, coupled with novel in vitro model systems to study disease mechanisms. Our research in the translational space bridges the fields of tissue engineering, biomaterials, drug delivery and stem cells, and is focused on arresting disease progression, restoring spine function and potentiating long term tissue regeneration. We use novel, naturally occurring and inducible large and small animal models to study disease etiology and evaluate therapeutics. Our multidisciplinary team includes biologists, bioengineers, clinicians and veterinarians.

Selected Publications

Gullbrand SE, Malhotra NR, Schaer TP, Zawacki Z, Martin JT, Bendigo J, Milby AH, Dodge GR, Vresilovic EJ, Elliott DM, Mauck RL, Smith LJ: A Large Animal Model that Recapitulates the Spectrum of Human Intervertebral Disc Degeneration. Osteoarthritis and Cartilage 25(1): 146-156, Jan 2017.

Gullbrand SE, Schaer TP, Bendigo JR, Agarwal P, Zawacki Z, Dodge GR, Vresilovic EJ, Elliott DM, Mauck RL, Malhotra NR, Smith LJ: Stem Cell Seeded Injectable Hydrogels for Intervertebral Disc Regeneration in a Preclinical Animal Model. 63rd Annual Meeting, Orthopaedic Research Society, San Diego, USA 2017 Notes: Podium.

Gullbrand SE, Schaer TP, Bendigo JR, Zawacki Z, Dodge GR, Vresilovic EJ, Elliott DM, Mauck RL, Malhotra NR, Smith LJ: Stem Cell Seeded Injectable Hydrogels for Intervertebral Disc Regeneration in a Preclinical Animal Model. International Society for the Study of the Lumbar Spine Annual Meeting, Athens, Greece 2017 Notes: Podium Presentation.

Piazza M, Peck SH, Gullbrand SE, Bendigo JR, Smith HE, Malhotra NR, Smith LJ: Comparison of Quantitative Imaging Techniques for Detecting Degenerative Changes in a Mouse Caudal Intervertebral Disc Injury Model. 63rd Annual Meeting, Orthopaedic Research Society, San Diego, USA 2017 Notes: Poster.

Peck SH, Bendigo JR, Gullbrand SE, Tobias JW, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Effects of Hypoxia and TGF-β Exposure during Monolayer Expansion on the Survival and Matrix Producing Capacity of Mesenchymal Stem Cells. 63rd Annual Meeting, Orthopaedic Research Society, San Diego, USA 2017 Notes: Poster.

Peck SH, Kang JL, Bendigo JR, O’Donnell P, Fitzgerald CA, Bagel J, Malhotra NR, Shore EM, Casal ML, Smith LJ: Rescuing Chondrocyte Hypertrophic Differentiation Potential and Exploring Therapeutic Approaches for Enhancing Bone Formation in Mucopolysaccharidosis VII Dogs. 63rd Annual Meeting, Orthopaedic Research Society, San Diego, USA 2017 Notes: Poster.

Gullbrand SE, Martin JT, Ashinsky BG, Kim DH, Smith LJ, Elliott DM, Smith HE, Mauck RL: Engineered Endplates Enhance the In Vivo Performance of a Replacement Disc-Like Angle Ply Structure (DAPS). 63rd Annual Meeting, Orthopaedic Research Society, San Diego, USA 2017 Notes: Podium. NIRA award winner.

Bendigo JR, Gullbrand SE, Stoeckl BD, Zawacki Z, Schaer TP, Smith HE, Mauck RL, Malhotra NR, Qu F, Smith LJ: Novel Techniques for the Evaluation of Physical Activity in a Large Animal Intervertebral Disc Degeneration Model. 63rd Annual Meeting, Orthopaedic Research Society, San Diego, USA 2017 Notes: Poster.

Martin JT, Gullbrand SE, Mohanraj B, Ashinsky BG, Kim DH, Ikuta K, Elliott DM, Smith LJ, Mauck RL, Smith HE: Optimization of pre-culture conditions to maximize in vivo performance of tissue engineered total disc replacements. Tissue Engineering Part A In press, 2017.

Peck SH, McKee KK, Malhotra NR, Harfe BD, Smith LJ: Growth Factor and Extracellular Matrix Expression and Localization during Nucleus Pulposus Formation. 63rd Annual Meeting, Orthopaedic Research Society, San Diego, USA 2017 Notes: Podium.

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Last updated: 07/14/2017
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