Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Faculty

Lachlan James Smith

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Research Assistant Professor of Neurosurgery
Department: Neurosurgery

Contact information
424 Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Education:
B.E. (Mechatronic Engineering)
University of Adelaide, 2001.
Ph.D. (Pathology)
University of Adelaide, 2008.
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Selected Publications

Kim DH, Martin JT, Elliott DM, Smith LJ, Mauck RL: Phenotypic Stability, Matrix Elaboration, and Functional Maturation of Nucleus Pulposus Cells Encapsulated in Photocrosslinkable Hyaluronic Acid Hydrogels. Acta Biomaterialia 15(12): 21-29, Jan 2015.

Farrell MJ, Shin JI, Smith LJ, Mauck RL: Functional consequences of glucose and oxygen deprivation on engineered mesenchymal stem cell-based cartilage constructs. Osteoarthritis Cartilage. 134-142 (eds.). 23(1), Jan 2015.

Peck SH, O’Donnell PJ, Chiaro JA, Shore EM, Pacifici M, Haskins ME, Malhotra NR, Smith LJ: Pinpointing the Earliest Manifestations of Bone Disease in Mucopolysaccharidosis Disorders. 61st Annual Meeting, Orthopaedic Research Society, Las Vegas, USA 2015 Notes: Poster.

Peck SH, O’Donnell PJ, Chiaro JA, Shore EM, Pacifici M, Haskins ME, Malhotra NR, Smith LJ: Failed vertebral bone formation in mucopolysaccharidosis VII dogs is associated with impaired chondrocyte hypertrophic differentiation. WORLD Symposium on Lysosomal Diseases, Orlando, USA 2015 Notes: Podium.

Gorth DG, Lothstein KE, Chiaro JA, Farrell MJ, Dodge GR, Elliott DM, Malhotra NR, Mauck RL, Smith LJ: Hypoxic Regulation of Functional Extracellular Matrix Elaboration by Nucleus Pulposus Cells in Long Term Agarose Culture. Journal of Orthopaedic Research 33(5): 747-754, May 2015.

Lothstein KE, O’Donnell PJ, Peck SH, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Preconditioning Stem Cells to Maximize Regenerative Potential in the Challenging Microenvironment of the Intervertebral Disc. 61st Annual Meeting, Orthopaedic Research Society, Las Vegas, USA 2015 Notes: Poster.

Martin JT, Ikuta K, Kim DH, Pfeifer CG, Smith LJ, Elliott DM, Smith HE, Mauck RL: Growth Trajectory and In vivo Implantation of Cellular Nanofibrous Disc-like Angle Ply Structures for Total Disc Replacement. 61st Annual Meeting, Orthopaedic Research Society, Las Vegas, USA 2015 Notes: Podium.

Chiaro JA, O'Donnell P, Shore EM, Malhotra NR, Ponder KP, Haskins ME, Smith LJ: Effects of Neonatal Enzyme Replacement Therapy and Simvastatin Treatment on Cervical Spine Disease in Mucopolysaccharidosis I Dogs. Journal of Bone and Mineral Research 29(12): 2610-2617, Dec 2014.

Gorth DG, Martin JT, Dodge GR, Malhotra NR, Elliott DM, Mauck RL, Smith LJ: In Vivo Retention and Bioactivity of IL-1ra Microspheres in the Rat Caudal Intervertebral Disc: A Preliminary Investigation. Journal of Experimental Orthopaedics 1(15), Nov 2014.

Smith LJ, Gorth DJ, Showalter BL, Chiaro JA, Beattie EE, Chen W, Elliott DM, Mauck RL, Malhotra NR: In Vitro Characterization of a Stem Cell-Seeded Triple Interpenetrating Network Hydrogel for Functional Regeneration of the Nucleus Pulposus. Tissue Engineering. Tissue Engineering: Part A 20(13-14): 1841-1849, Jul 2014.

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Last updated: 09/02/2015
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