Department of Microbiology

faculty photo

Kyong-Mi Chang, M.D.

Associate Professor of Medicine
Member, Abramson Cancer Center, University of Pennsylvania
Member, CAMB, Microbiology, Virology and Parasitology Program, University of Pennsylvania
Member, Center for AIDS Research, University of Pennsylvania
Co-Director, Immunology Program, NIH Center for Molecular Studies in Digestive & Liver Diseases, University of Pennsylvania
Associate Director, Penn Center for Viral Hepatitis, Hospital of University of Pennsylvania
Associate Chief of Staff for Research, Philadelphia VA Medical Center
Associate Dean for Research at the Philadelphia VA Medical Center, University of Pennsylvanina
Department: Medicine

Contact information
A424, Medical Research Building
Philadelphia VA Medical Center
University and Woodland Ave
Philadelphia, PA 19104
Office: (215) 823-5893
Fax: (215) 823-4394
Lab: (215) 823-5800 ext 6730
Graduate Group Affiliations
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
The Medical College of Pennsylvania, 1987.
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Description of Research Expertise

- immune mechanisms of viral persistence and liver disease progression in patients infected with hepatitis C virus (HCV) and hepatitis B virus (HBV)
-high dimensional single cell immune analysis through Mass Cytometry using CyTOF2, examining 30-40 parameters at a single cell level.
-emerging expertise in genetic analysis of cardiometabolic diseases with extension to other organs (e.g. liver) using the VA Million Veterans Program (MVP) genetic and clinical databases

Description of Clinical Expertise

Dr. Chang's clinical area of expertise is in the evaluation, treatment and study of patients with acute and chronic viral hepatitis B and C, with and without HIV coinfection. She established and directed the active GI/Liver clinic at the Philadelphia VA Medical Center in 1999-2012. She continues to supervise GI fellows and rotating students/residents in the GI/Liver clinic to date.

Description of Other Expertise

Dr. Chang is the Associate Chief of Research (ACOS/R&D) and Associate Dean for Research at the Philadelphia Corporal Michael J Crescenz VA Medical Center, which is academically affiliated with the University of Pennsylvania. As such, Dr. Chang has the administrative oversight in developing VA-based and/or VA-funded research by VA/Penn dual-appointed Penn faculty at the Philadelphia VA Medical Center.

Selected Publications

Wang YJ, Golson ML, Schug J. Traum D, Liu C, Vivek K, Dorrel C, Naji A, Powers AC, Chang KM, Grompe M, Kaestner KH.: Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas. Cell Metabolism 24(4): 616-626, October 2016.

Bengsch, B, Chang KM, : Evolution in our understanding of hepatitis B virus virology and immunology. Clin Liver Dis. 2016 Paul Martin (eds.). Elsevier, 20(3), August 2016.

Chang, KM, Liu M: Chronic hepatitis B: Immune pathogenesis and emerging immunotherapeutics. Current Opin Pharmacol 20: 93-105, August 2016.

Cozen ML, Ryan JC, Shen H, Cheung R, Kaplan DE, Pocha C, Brau N, Aytaman A, Schmidt WN, Pedrosa M, Anand BS, Chang KM, Morgan T, Monto A. : Improved Survival Among all Interferon-α-Treated Patients in HCV-002, a Veterans Affairs Hepatitis C Cohort of 2211 Patients, Despite Increased Cirrhosis Among Nonresponders. Dig Dis Sci 61(6): 1744-1756, June 2016.

Park J., DK Wong, AS Wahed, WM Lee, JJ. Feld JJ, N Terrault N, M Khalili, RK. Sterling, KV KowdleY, N Bzowej N, DT. Lau, WR Kim WR, C SmitH, RL Carithers, KW Torrey , JW Keith, DL Levine, D Traum, S Ho, ME Valiga, GS. Johnson, E Doo, ASF. Lok, and KM Chang. : HBV-specific and global T-cell dysfunction in chronic hepatitis B. Gastroenterology 150(3): 684-695, March 2016.

Terrault NA, Bzowej NH, Chang KM, Hwang JP, Jonas MM, Murad MH: AASLD guidelines for treatment of chronic hepatitis B. Hepatology 63(1): 261-83, January 2016.

O’Leary TJ., Dominitz JA, Chang KM: Veterans Affairs (VA) Office of Research and Development (ORD): Research Programs and Emerging Opportunities in Digestive Disease Research. Gastroenterology 149(7): 1652-1661, December 2015.

Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS: Present and future therapies of hepatitis B: From discovery to cure. Hepatology 62(6): 1893-908, December 2015.

Khalili M, Lombardero M, Chung RT, Terrault NA, Ghany MG, Kim WR, Lau D, Lisker-Melman M, Sanyal A, Lok AS; HBRN. Collaborators (33) Roberts LR, Smith CI, Di Bisceglie AM, Brunt EM, Janssen HL, Wong DK, Juan J, Feld J, Yim C, Heathcote J, Lee WM, Perrillo R, Do S, Han SH, Tran TT, Cooper SL, Fontana RJ, Tsai N, Fried MW, Patel K, Evon D, Carithers RC, Shuhart M, Kowdley KV, Wang CC, Sterling RK, Liang TJ, Chang KM, Park JJ, Belle S, Wahed A, Cloonan Y, Kleiner D.: Diabetes and prediabetes in patients with hepatitis B residing in North America. Hepatology 62(5): 1364-74, November 2015 Notes: (cited among the collaborators).

O’Leary TJ., Dominitz JA, Chang KM: Editorial: Veterans Affairs (VA) Office of Research and Development (ORD): Research Programs and Emerging Opportunities in Digestive Disease Research. Gastroenterology October 2015.

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Last updated: 10/15/2016
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