faculty photo

John Frederick Brandsema, M.D.

Associate Professor of Clinical Neurology
Department: Neurology

Contact information
Division of Neurology
Children's Hospital of Philadelphia
3501 Civic Center Blvd., 1st Floor
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: 215-590-1719
Fax: 215-590-1771
Education:
IB
Armand Hammer United World College of the American West, 1998.
BA (Biochemistry and Molecular Biology/Music Double Major)
Dartmouth College, 2002.
M.D.
Dalhousie University, 2007.
Post-Graduate Training
Resident in Pediatric Neurology, The Hospital for Sick Children, Toronto, 2007-2012.
Fellowship, Neuromuscular Medicine, Harvard/Partners, 2012-2013.
CHOP Physician Leadership Program, CHOP, 2017-2018.
CHOP Improvement Leadership Course, CHOP, 2018-2018.
Certifications
Fellow of the Royal College of Physicians and Surgeons of Canada (Neurology), 2012.
American Board of Psychiatry and Neurology Certification in Child Neurology, 2014.
American Board of Electrodiagnostic Medicine: Electrodiagnostic Medicine, 2015.
American Board of Psychiatry and Neurology Certification in Neuromuscular Medicine, 2016.
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Selected Publications

Mohassel P, Yun P, Syeda S….Brandsema J...Bonnemann, CG: A comprehensive study of skeletal muscle imaging in FHL1-related reducing body myopathy. Ann Clin Transl Neurol Jul 2023 Notes: epub ahead of print.

Richard S. Finkel, Basil T. Darras, Jerry R. Mendell….John F. Brandsema…Sitra Tauscher-Wisniewski: Intrathecal Onasemnogene Abeparvovec for Sitting, Nonambulatory Patients with Spinal Muscular Atrophy: Phase I Ascending-Dose Study (STRONG). J Neuromuscul Dis 10(3): 389-404, 2023.

Connolly AM, Zaidman CM, Brandsema JF, et al.: Pamrevlumab, a Fully Human Monoclonal Antibody Targeting Connective Tissue Growth Factor, for Non-Ambulatory Patients with Duchenne Muscular Dystrophy. J Neuromuscul Dis 10(4): 685-699, 2023.

Kichula EA, Brandsema JF: Highly Effective Gene Therapies for SMA: Where Do We Go From Here? NeurologyLive.Com August 2022.

Muntoni F, Guglieri M, Mah JK…Brandsema JF…Mercuri E: Novel approaches to analysis of the North Star Ambulatory Assessment (NSAA) in Duchenne muscular dystrophy (DMD): Observations from a phase 2 trial. PLoS One 17(8): eCollection, Aug 2022.

Sarah P Sherlock, Jeffrey Palmer, Kathryn R Wagner, Hoda Z Abdel-Hamid, Enrico Bertini, Cuixia Tian, Jean K Mah, Anna Kostera-Pruszczyk, Francesco Muntoni, Michela Guglieri, John F Brandsema, Eugenio Mercuri, Russell J Butterfield, Craig M McDonald, Lawrence Charnas, Shannon Marraffino : Quantitative magnetic resonance imaging measures as biomarkers of disease progression in boys with Duchenne muscular dystrophy: a phase 2 trial of domagrozumab J Neurol Apr 2022 Notes: epub ahead of print.

Mejia EJ, Lin KY, Okunowo O,..Brandsema JF…Edelson JB: Health Care Use of Cardiac Specialty Care in Children With Muscular Dystrophy in the United States. Journal of the American Heart Association 11(8), Apr 2022 Notes: epub ahead of print.

Brandsema, J: Genetic Neurodegenerative Disorders: Close to a Symptom-Free Life? NeurologyLive 5(1), Feb 2022 Notes: Online Article.

Brandsema et al: Baseline Characteristics and Initial Safety Results in RESPOND: A Phase 4 Study of Nusinersen in Children with Spinal Muscular Atrophy (SMA) Who Received Onasemnogene Abeparvovec. American Academy of Neurology Annual Conference in Seattle, WA 2022 Notes: Poster Presentation.

Katrine M Johannesen, Elena Gardella, Cathrine E Gjerulfsen, Allan Bayat, Rob P W Rouhl, Margot Reijnders, Sandra Whalen, Boris Keren, Julien Buratti, Thomas Courtin, Klaas J Wierenga, Bertrand Isidor, Amélie Piton, Laurence Faivre, Aurore Garde, Sébastien Moutton, Frédéric Tran-Mau-Them, Anne-Sophie Denommé-Pichon, Christine Coubes, Austin Larson, Michael J Esser, Juan Pablo Appendino, Walla Al-Hertani, Beatriz Gamboni, Alejandra Mampel, Lía Mayorga, Alessandro Orsini, Alice Bonuccelli, Agnese Suppiej, Julien Van-Gils, Julie Vogt, Simona Damioli, Lucio Giordano, Stephanie Moortgat, Elaine Wirrell, Sarah Hicks, Usha Kini, Nathan Noble, Helen Stewart, Shailesh Asakar, Julie S Cohen, SakkuBai R Naidu, Ashley Collier, Eva H Brilstra, Mindy H Li, Casey Brew, Stefania Bigoni, Davide Ognibene, Elisa Ballardini, Claudia Ruivenkamp, Raffaella Faggioli, Alexandra Afenjar, Diana Rodriguez, David Bick, Devorah Segal, David Coman, Boudewijn Gunning, Orrin Devinsky, Laurie A Demmer, Theresa Grebe, Dario Pruna, Ida Cursio, Lynn Greenhalgh, Claudio Graziano, Rahul Raman Singh, Gaetano Cantalupo, Marjolaine Willems, Sangeetha Yoganathan, Fernanda Góes, Richard J Leventer, Davide Colavito, Sara Olivotto, Barbara Scelsa, Andrea V Andrade, Kelly Ratke, Farha Tokarz, Atiya S Khan, Clothilde Ormieres 1 , William Benko 1 , Karen Keough 1 , Sotirios Keros, Shanawaz Hussain, Ashlea Franques, Felicia Varsalone, Sabine Grønborg, Cyril Mignot, Delphine Heron, Caroline Nava, Arnaud Isapof, Felippe Borlot, Robyn Whitney, Anne Ronan, Nicola Foulds, Marta Somorai, John Brandsema, Katherine L Helbig, Ingo Helbig, Xilma R Ortiz-González, Holly Dubbs, Antonio Vitobello, Mel Anderson, Dominic Spadafore, David Hunt, Rikke S Møller, Guido Rubboli, PURA study group : PURA- Related Developmental and Epileptic Encephalopathy: Phenotypic and Genotypic Spectrum Neurol Genet 7(6): e613, Nov 2021.

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Last updated: 08/03/2023
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