University of Pennsylvania Health System

Department of Ophthalmology

Ophthalmology Faculty

Albert M. Maguire, MD

faculty photo
Professor of Ophthalmology at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Researcher, Center for Cellular and Molecular Therapeutics at The Children's Hospital of Philadelphia
Department: Ophthalmology

Contact information
Scheie Eye Institute
Department of Ophthalmology
University of Pennsylvania
51 North 39th Street
Philadelphia, PA 19104
Education:
B.A.
Princeton University (magna cum laude), 1982.
M.D.
Harvard University, 1986.
Post-Graduate Training
Intern in Surgery, Yale-New Haven Hospital, Department of Surgery, Yale University School of Medicine, New Haven, CT, 1986-1987.
Resident in Ophthalmology, The Wilmer Ophthalmological Institute, The Johns Hopkins Hospital, Baltimore, MD, 1987-1990.
Fellowship, Associated Retinal Consultants, William Beaumont Hospital, Royal Oak, MI, 1990-1991.
Certifications
American Board of Ophthalmology, 1991.
SOCA Eligible and Certified Personnel, 2002.
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Description of Research Expertise

Gene therapy for retinal degeneration, gene therapy for ocular neovascularization, Subretinal surgery

Description of Clinical Expertise

diabetic retinopathy, retinopathy of prematurity, macular degeneration, sickle cell disease, gene therapy, retinal degeneration

Selected Publications

Bennett J, Ashtari M, Wellman J, Marshall KA, Cyckowski LL, Chung DC, McCague S, Pierce EA, Chen Y, Bennicelli JL, Zhu X, Ying GS, Sun J, Wright JF, Auricchio A, Simonelli F, Shindler KS, Mingozzi F, High KA, Maguire AM.: AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness. Sci Transl Med. 4(120): 120ra15, Feb 2012.

Ashtari M, Cyckowski LL, Monroe JF, Marshall KA, Chung DC, Auricchio A, Simonelli F, Leroy BP, Maguire AM, Shindler K, Bennett J.: The human visual cortex responds to gene therapy–mediated recovery of retinal function. J Clin Invest. 121(6): 2160-8, June 2011 Notes: doi: 10.1172/JCI57377. Epub 2011 May 23.

Vandenberghe LH, Bell P, Maguire AM, Cearley CN, Xiao R, Calcedo R, Wang L, Castle MJ, Maguire AC, Grant R, Wolfe JH, Wilson JM, Bennett J.: Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey. Sci Transl Med. 3(88): 88ra54, June 2011.

Simonelli F, Maguire AM, Testa F, Pierce EA, Mingozzi F, Bennicelli JL, Rossi S, Marshall K, Banfi S, Surace EM, Sun J, Redmond TM, Zhu X, Shindler KS, Ying GS, Ziviello C, Acerra C, Wright JF, McDonnell JW, High KA, Bennett J, Auricchio A.: Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration. Mol Ther. 18(3): 643-50, March 2010 Notes: Epub 2009 Dec 1.

Amado D, Mingozzi F, Hui D, Bennicelli JL, Wei Z, Chen Y, Bote E, Grant RL, Golden JA, Narfstrom K, Syed NA, Orlin SE, High KA, Maguire AM, Bennett J.: Safety and efficacy of subretinal readministration of a viral vector in large animals to treat congenital blindness. Sci Transl Med. 2(21): 21ra16, March 2010.

Maguire AM, High KA, Auricchio A, Wright JF, Pierce EA, Testa F, Mingozzi F, Bennicelli JL, Ying GS, Rossi S, Fulton A, Marshall KA, Banfi S, Chung DC, Morgan JI, Hauck B, Zelenaia O, Zhu X, Raffini L, Coppieters F, De Baere E, Shindler KS, Volpe NJ, Surace EM, Acerra C, Lyubarsky A, Redmond TM, Stone E, Sun J, McDonnell JW, Leroy BP, Simonelli F, Bennett J.: Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial. Lancet. 374(9701): 1597-605. Nov 2009 Notes: Epub 2009 Oct 23.

Chung DC, Lee V, Maguire AM.: Recent advances in ocular gene therapy. Curr Opin Ophthalmol. 20(5): 377-81, September 2009.

Maguire AM, Simonelli F, Pierce EA, Pugh EN Jr, Mingozzi F, Bennicelli J, Banfi S, Marshall KA, Testa F, Surace EM, Rossi S, Lyubarsky A, Arruda VR, Konkle B, Stone E, Sun J, Jacobs J, Dell'Osso L, Hertle R, Ma JX, Redmond TM, Zhu X, Hauck B, Zelenaia O, Shindler KS, Maguire MG, Wright JF, Volpe NJ, McDonnell JW, Auricchio A, High KA, Bennett J.: Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med. 358(21): 2240-8, May 2008 Notes: Epub 2008 Apr 27.

Allocca M, Doria M, Petrillo M, Colella P, Garcia-Hoyos M, Gibbs D, Kim SR, Maguire A, Rex TS, Di Vicino U, Cutillo L, Sparrow JR, Williams DS, Bennett J, Auricchio A.: Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice. J Clin Invest. 118(5): 1955-64, May 2008.

Lebherz C, Maguire A, Tang W, Bennett J, Wilson JM.: Novel AAV serotypes for improved ocular gene transfer. J Gene Med. 10(4): 375-82, April 2008.

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Last updated: 01/24/2014
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