University of Pennsylvania Health System

Department of Ophthalmology

Ophthalmology Faculty

Faculty Overview

Albert M. Maguire, MD

faculty photo
F.M. Kirby Professor of Molecular Ophthalmology
Co-Director, Fellowship Program, Vitreoretinal Surgery, University of Pennsylvania
Co-Director, Center for Retinal and Ocular Therapeutics (CAROT), University of Pennsylvania Perelman School of Medicine
Department: Ophthalmology

Contact information
Scheie Eye Institute
Department of Ophthalmology
University of Pennsylvania
51 North 39th Street
Philadelphia, PA 19104
Princeton University (magna cum laude), 1982.
Harvard University, 1986.
Post-Graduate Training
Intern in Surgery, Yale-New Haven Hospital, Department of Surgery, Yale University School of Medicine, New Haven, CT, 1986-1987.
Resident in Ophthalmology, The Wilmer Ophthalmological Institute, The Johns Hopkins Hospital, Baltimore, MD, 1987-1990.
Fellowship, Associated Retinal Consultants, William Beaumont Hospital, Royal Oak, MI, 1990-1991.
American Board of Ophthalmology, 1991.
SOCA Eligible and Certified Personnel, 2002.
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Description of Research Expertise

Gene therapy for retinal degeneration, gene therapy for ocular neovascularization, Subretinal surgery; Animal models; Recombinant Adeno-Associated Virus (AAV); Retinal Function and Functional Vision Outcome Measures

Description of Clinical Expertise

diabetic retinopathy, retinopathy of prematurity, macular degeneration, sickle cell disease, gene therapy, retinal degeneration; von Hippel-Lindau Syndrome

Selected Publications

Ashtari, M, Cook, P, Lipin, M, Yu, Y, Ying, G-S, Maguire, AM, Bennett, J, Gee, J, Zhang, H: Dynamic structural remodeling of the human visual system prompted by bilateral retinal gene therapy. Current Research in Neurobiology 4: online 4 June 2023, June 2023 Notes:

Tsui, JC, Wong, MB, Kim, BJ, Maguire, AM, Scoles, D, VanderBeek, BL, Brucker, AJ: Appropriateness of ophthalmic symptoms triage by a popular online artifician intelligence chatbot. Eye (Lond) 32(e24), Apr 2023.

Andersen, T, Miller, CG, Xia, T, Pulido, JS, Brucker, AJ, Maguire, AM: Vitreoretinal lymphoma presenting as frosted branch angiitis in a patient with diffuse large B-cell lymphoma. Am J Ophthalmol Case Rep 30: 101838, Mar 2023.

Bennett, J, Aleman, EMM, Maguire, HK, Weber, ML, Maguire, WM, Maja, A, O'Neil, EC, Maguire, AM, Miller, AJ and Aleman, TS: Optimization and validation of a virtual reality orientation and ombility test for inherited retinal degenerations. Transl Vis Sci Technol 12(1): 28, Jan 2023.

Silson, EH, Baker, C, Aleman, TS, Maguire, AM, Bennett, J and Ashtari, M: Motion-selective areas V5/MT and MST appear resistant to deterioration in choroideremia. Neuroimage Clin. 38, 2023.

Aleman, TS, Huckfeldt, RM, Serrano, LW, Pearson, DJ, Vergilio, GK, McCague, S, Marshall, KA, Ashtari, M, Doan, TM, Weigel-DiFranco, CA, Biron, BS, Wen, XH, Chung, DC, Liu, E, Ferenchak, K, Morgan, JIW, Pierce, EA, Eliott, D, Bennett, J, Comander, J, Maguire, AM: Adeno-Associated Virus Serotype 2-hCHM Subretinal Delivery to the Macula in Choroideremia: Two-Year Interim Results of an Ongoing Phase I/II Gene Therapy Trial. Ophthalmology 129(10): 1177-1191, Oct 2022.

Nikonov, S, Aravan, P, Lyubarsky, A, Nikonov, R, Luo, AJ, Wei, Z, Maguire, AM, Phelps, TT, Shpylchak, I, Willett, K, Aleman, TS, Huckfeldt, RM, Ramachandran, P, Bennett, J: Restoration of vision and retinal responses after AAV-mediated optogenetic therapy in blind dogs. Transl Vis Sci Technol 11(5): 24, May 2022.

Benett, J and Maguire, AM: Lessons Learned from the Development of the First FDA-Approved Gene Thrapy Drug, Voretigene Neparvovec-rzyl. Cold Spring Harb Perspect Med 140(4): 411-420, Apr 2022.

Morgan, JIW, Jiang, YY, Vergilio, GK, Serrano, L, Pearson, DJ, Bennett, J, Maguire, AM and ALeman, TS: Short-term assessment of subfoveal injection of adeno-associated virus-mediated hCHM gene augmentation in choroideremia using adaptive optics ophthalmoscopy. JAMA Ophthalmol 140(4): 411-420, Apr 2022.

Ashtari, M, Lipin, M, Duong, M, Ying, GS, Yu, Y, Maguire A, Bennett, J: Neuroplasticity of the Lateral Geniculate Nucleus in Response to Retinal Gene Therapy in a Group of Patients with RPE65 Mutations. Eye Brain 14: 137-147, 2022.

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Last updated: 06/18/2023
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