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Anne Rentoumis Cappola, MD, ScM

Professor of Medicine
Department: Medicine

Contact information
Division of Endocrinology, Diabetes, and Metabolism
Room 12-136
Smilow Center for Translational Research, 12th floor
3400 Civic Center Blvd., Building 421
Philadelphia, PA 19104-5160
Office: (215) 573-5359
Fax: (215) 898-5408
Education:
B.A. (Biochemistry )
Harvard College (Advanced Standing), Cambridge, MA, 1990.
M.D.
University of Pennsylvania School of Medicine, 1994.
Sc.M. (Clinical Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2001.
Post-Graduate Training
Intern and Resident, Internal Medicine, Brigham and Women's Hospital, Boston, MA, 1994-1997.
Clinical Fellow, Endocrinology, Massachusetts General Hospital, Boston, MA, 1997-1998.
Clinical and Research Fellow, Endocrinology and Metabolism, Johns Hopkins Hospital, Baltimore, MD, 1998-2000.
Research Fellow, Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, MD, 1999-2001.
Senior Honorary Visiting Fellow, University of Cambridge, Cambridge, UK, 2013-2014.
Certifications
American Board of Internal Medicine Certification in Internal Medicine, 1997.
American Board of Internal Medicine Certification in Endocrinology and Metabolism, 1999.
American College of Epidemiology, 2004.
American Board of Internal Medicine Recertification in Endocrinology and Metabolism, 2009.
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Description of Research Expertise

Anne Rentoumis Cappola, M.D., Sc.M. is a Professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism; Director of the CTSA-sponsored Center for Human Phenomic Science; and Director of Clinical Research for the Department of Medicine. She is an Associate Editor for the Journal of the American Medical Association (JAMA).

Dr. Cappola leads an NIH-funded program focusing on the hormonal alterations that occur with aging and the clinical impact of these changes Current projects include studies of the indications for treatment of subclinical thyroid dysfunction in older men and women; the role of androgens in the health of older women; hormonal treatments for the frailty syndrome; and metabolic changes in men and women who sustain a hip fracture.

Selected Publications

Aubert CE, Floriani C, Bauer DC, da Costa BR, Segna D, Blum MR, Collet TH, Fink HA, Cappola AR, Syrogiannouli L, Peeters RP, Åsvold BO, den Elzen WP, Luben RN, Bremner AP, Gogakos A, Eastell R, Kearney PM, Hoff M, Le Blanc E, Ceresini G, Rivadeneira F, Uitterlinden AG, Khaw KT, Langhammer A, Stott DJ, Westendorp RG, Ferrucci L, Williams GR, Gussekloo J, Walsh JP, Augjesky D, Rodondi N for the Thyroid Studies Collaboration: Thyroid function tests in the reference range and fracture: individual participant analysis of prospective cohorts. J Clin Endocrinol Metab 102(8): 2719-2728, Aug 2017.

Chaker L, Korevaar TIM, Rizopoulos D, Collet TH, Völzke H, Hofman A, Rodondi N, Cappola AR, Peeters RP, Franco OH: Defining optimal health range for thyroid function based on the risk of cardiovascular disease. J Clin Endocrinol Metab 102(8): 2853-2861, Aug 2017.

Liang J, Le TH, Edwards DRV, Tayo BO, Gaulton KJ, Smith JA, Lu Y, Jensen RA, Chen G, Yanek LR, Schwander K, Tajuddin SM, Sofer T, Kim W, Kayima J, McKenzie CA, Fox E, Nalls MA, Young JH, Sun YV, Lane JM, Cechova S, Zhou J, Tang H, Fornage M, Musani SK, Wang H, Lee J, Adeyemo A, Dreisbach AW, Forrester T, Chu PL, Cappola A, Evans MK, Morrison AC, Martin LW, Wiggins KL, Hui Q, Zhao W, Jackson RD, Ware EB, Faul JD, Reiner AP, Bray M, Denny JC, Mosley TH, Palmas W, Guo X, Papanicolaou GJ, Penman AD, Polak JF, Rice K, Taylor KD, Boerwinkle E, Bottinger EP, Liu K, Risch N, Hunt SC, Kooperberg C, Zonderman AB, Laurie CC, Becker DM, Cai J, Loos RJF, Psaty BM, Weir DR, Kardia SLR, Arnett DK, Won S, Edwards TL, Redline S, Cooper RS, Rao DC, Rotter JI, Rotimi C, Levy D, Chakravarti A, Zhu X, Franceschini N: Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations. PLoS Genet 13(5): e1006728, May 2017.

Koenig AM, Mechanic-Hamilton D, Xie SX, Combs MF, Cappola AR, Xie L, Detre JA, Wolk DA, Arnold SE: Effects of the insulin sensitizer metformin in Alzheimer Disease: pilot data from a randomized placebo-controlled crossover study. Alzheimer Dis Assoc Disord 31(2): 107-113, Apr-Jun 2017.

Kaplan RC, Strizich G, Aneke-Nash C, Dominguez-Islas C, Buzkova P, Strickler H, Rohan T, Pollak M, Kuller L, Kizer JR, Cappola A, Li CI, Psaty BM, Newman A: Insulinlike growth factor binding protein-1 and ghrelin predict health outcomes among older adults: CHS cohort. J Clin Endocrinol Metab 102(1): 267-278, Jan 2017.

Chaker L, Baumgartner C, den Elzen WP, Collet TH, Ikram MA, Blum MR, Dehghan A, Drechsler C, Luben RN, Portegies ML, Iervasi G, Medici M, Stott DJ, Dullaart RP, Ford I, Bremner A, Newman AB, Wanner C, Sgarbi JA, Dörr M, Longstreth WT Jr, Psaty BM, Ferrucci L, Maciel RM, Westendorp RG, Jukema JW, Ceresini G, Imaizumi M, Hofman A, Bakker SJ, Franklyn JA, Khaw KT, Bauer DC, Walsh JP, Razvi S, Gussekloo J, Völzke H, Franco OH, Cappola AR, Rodondi N, Peeters RP, for the Thyroid Studies Collaboration: Thyroid function within the reference range and the risk of stroke: an individual participant data analysis. J Clin Endocrinol Metab 101(11): 4270-4282, Nov 2016.

Teumer A, Qi Q, Nethander M, Aschard H, Bandinelli S, Beekman M, Berndt SI, Bidlingmaier M, Broer L; CHARGE Longevity Working Group, Cappola A, Ceda GP, Chanock S, Chen MH, Chen TC, Chen YD, Chung J, Del Greco Miglianico F, Eriksson J, Ferrucci L, Friedrich N, Gnewuch C, Goodarzi MO, Grarup N, Guo T, Hammer E, Hayes RB, Hicks AA, Hofman A, Houwing-Duistermaat JJ, Hu F, Hunter DJ, Husemoen LL, Isaacs A, Jacobs KB, Janssen JA, Jansson JO, Jehmlich N, Johnson S, Juul A, Karlsson M, Kilpelainen TO, Kovacs P, Kraft P, Li C, Linneberg A, Liu Y, Loos RJ; Body Composition Genetics Consortium, Lorentzon M, Lu Y, Maggio M, Magi R, Meigs J, Mellström D, Nauck M, Newman AB, Pollak MN, Pramstaller PP, Prokopenko I, Psaty BM, Reincke M, Rimm EB, Rotter JI, Saint Pierre A, Schurmann C, Seshadri S, Sjögren K, Slagboom PE, Strickler HD, Stumvoll M, Suh Y, Sun Q, Zhang C, Svensson J, Tanaka T, Tare A, Tönjes A, Uh HW, van Duijn CM, van Heemst D, Vandenput L, Vasan RS, Völker U, Willems SM, Ohlsson C, Wallaschofski H, Kaplan RC: Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. Aging Cell 15(5): 811-24, Oct 2016.

Maggio M, de Vita F, Lauretani F, Bandinelli S, Semba RD, Bartali B, Cherubini A, Cappola AR, Ceda GP, Ferrucci L: Relationship between carotenoids, retinol, and estradiol levels in older women. Nutrients 7(8): 6506-19, Aug 2015.

Åsvold BO, Vatten LJ, Bjøro T, Bauer DC, Bremner A, Cappola AR, Ceresini G, den Elzen WPJ, Ferrucci L, Franco OH, Franklyn JA, Gussekloo J, Iervasi G Imaizumi M, Kearney PM, Khaw KT, Newman AB, Peeters RP, Psaty BM, Razvi S, Sgarbi JA, Stott DK, Trompet S, Vanderpump MP, Völzke H, Walsh JP, Westendorp RG, Rodondi N, for the Thyroid Studies Collaboration: Thyroid function within the normal range and risk of coronary heart disease. JAMA-Internal Medicine 175(6): 1037-47, Jun 2015.

Chaker L, Baumgartner C, den Elzen W, Ikram, MA, Blum MR, Collet TH, Bakker SJ, Dehgha A, Drechsler C, Luben RN, Hofman A, Portegies ML, Medici M, Iervasi G, Stott DJ, Ford I, Bremner A, Wanner C, Ferrucci L, Newman A, Dullaart RP, Sgarbi JA, Ceresini G, Maciel RM, Westendorp R, Jukema JW, Imaizumi M, Franklyn JA, Bauer DC, Walsh JP, Rasvi S, Khaw KT, Cappola AR, Völzke H, Franco OH, Gussekloo J, Rodondi N, Peeters RP: Subclinical hypothyroidism and the risk of stroke events and fatal stroke: an individual participant data analysis. J Clin Endocrinol Metab 100(6): 2181-91, Jun 2015.

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Last updated: 08/22/2017
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