Robert B. Wilson

faculty photo
Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Attending Physician, Clinical Molecular Pathology Laboratory, University of Pennsylvania Medical Center
Co-Director, Penn Medicine and Children's Hospital of Philadelphia Friedreich's Ataxia Center of Excellence
Department: Pathology and Laboratory Medicine

Contact information
Department of Pathology and Laboratory Medicine
University of Pennsylvania Medical Center
Room 509A, Stellar-Chance Laboratories
422 Curie Blvd
Philadelphia, PA 19104
Office: 215-898-0606
Sc.B. (Biochemistry)
Brown University, 1982.
A.B. (Music)
Brown University, 1982.
University of Pennsylvania, 1989.
Ph.D. (Genetics)
University of Pennsylvania, 1989.
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Description of Itmat Expertise

Dr. Wilson's primary interest is in the neurodegenerative disorder Friedreich ataxia, for which he completed a high-throughput drug screen of >340,000 compounds in the fall of 2008. He is now working with medicinal chemists on the hit compounds. He is also involved in screening a random shRNA expressing library for small RNAs to be used as therapeutics and biologic tools. The random shRNA expressing library and its use is described in a PLoS ONE manuscript that can be accessed openly at the following URL:

Selected Publications

Wang, Y., Speier, J., Engram-Pearl, J., Wilson, R. B.: Introduction of Mismatches in a Random shRNA-encoding Library Improves Potency for Phenotypic Selection. PLoS ONE 9: e87390, 2014.

Cotticelli, M. G., Crabbe, A. M., Wilson, R. B., and Shchepinov, M. S.: Insights into the role of oxidative stress in the pathology of Friedreich Ataxia using peroxidation resistant polyunsaturated fatty acids. Redox Biology 1: 398-404, 2013.

Lynch, D. R., Willi, S. M., Wilson, R. B., Cotticelli, M. G., Brigatti, K., Deutsch, E. C., Kucheruk, O., Shrader, W., Rioux, P., Miller, G., Hawi, A., Sciascia, T.: A0001 in Friedreich ataxia: Biochemical characterization and effects in a clinical trial. Movement Disorders 8: 1026-1033, 2012.

Cotticelli, M.G., Rasmussen ,L., Kushner, N. L., McKellip, S., Sosa, M. I., Manouvakhova, A., Feng, S., White, E. L., Maddry, J. A., Heemskerk, J., Oldt, R. J., Surrey, L. F., Ochs, R., and Wilson, R. B.: Primary and Secondary Drug Screening Assays for Friedreich Ataxia. J. Biomol. Screening 17: 303-313, 2011.

Myers, L., Lynch, D. R., Farmer, J. M., Friedman, L., Lawson, J. A., Wilson, R. B.: Urinary isoprostanes in Friedreich Ataxia: lack of correlation with disease features. Movement Disorders 23: 1920-1922, 2009.

Soper, J., Roy, S., Steiber, A., Lee, E., Wilson, R.B., Burd, C., Lee, V.M.-Y.: Alpha-Synuclein induced Aggregation of Cytoplasmic Vesicles in S. cerevisiae. Mol. Biol. Cell 19: 1093-1103, 2008.

Myers, L., Farmer, J.M., Wilson, R.B., Tsou, A., Perlman, S., Subramony, S.H., Gomez, C.M., Ashizawa, T., Wilmot, G.R., Matthews, K., Balcer, L.J., Lynch, D.R.: Antioxidant use in Friedreich ataxia. J. Neurol. Sci. 267: 174-176, 2008.

Wang, Y., Wang, Y. E., Cotticelli, M. G., Wilson, R. B.: A random shRNA-encoding library for phenotypic selection and hit-optimization. PLoS ONE 3: e3171, 2008.

Stolle, C. A., Frackelton, E. C., McCallum, J., Farmer, J. M., Tsou, A., Wilson, R. B., Lynch, D. R.: Novel, complex interruptions of the GAA repeat in small, expanded alleles of two affected siblings with late-onset Friedreich ataxia. Movement Disorders 23: 1303-1306, 2008.

Epstein, E., Farmer, J. M., Tsou, A., Perlman, S., Subramony, H., Gomez, C. M., Ashizawa, T., Wilmot, G. R., Mathews, K., Wilson, R. B., Balcer, L. J., Lynch, D. R.: Health related quality of life measures in Friedreich ataxia. J. Neurol. Sci. 272: 123-128, 2008.

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Last updated: 01/20/2015
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