Robert B. Wilson
Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Co-Director, Penn Medicine and Children's Hospital of Philadelphia Friedreich's Ataxia Center of Excellence
Attending Physician, Division of Genomic Diagnostics, Children's Hospital of Philadelphia
Senior Scientist, Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia
Chief, Division of Pathology Informatics, Children's Hospital of Philadelphia
Department: Pathology and Laboratory Medicine
Contact information
Department of Pathology and Laboratory Medicine
Children’s Hospital of Philadelphia
Room 6024, Colket Translational Research Building
3501 Civic Center Blvd.
Philadelphia, PA 19104
Children’s Hospital of Philadelphia
Room 6024, Colket Translational Research Building
3501 Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-425-2201
Email:
WILSONR@MAIL.MED.UPENN.EDU
WILSONR@MAIL.MED.UPENN.EDU
Education:
Sc.B. (Biochemistry)
Brown University, 1982.
A.B. (Music)
Brown University, 1982.
M.D.
University of Pennsylvania, 1989.
Ph.D. (Genetics)
University of Pennsylvania, 1989.
Sc.B. (Biochemistry)
Brown University, 1982.
A.B. (Music)
Brown University, 1982.
M.D.
University of Pennsylvania, 1989.
Ph.D. (Genetics)
University of Pennsylvania, 1989.
Post-Graduate Training
Residency in Clinical Pathology, Hospital of the University of Pennsylvania, Philadelphia, 1989-1992.
Post-doctoral Research, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, 1991-1993.
Fellowship in Transfusion Medicine, Hospital of the University of Pennsylvania, Philadelphia, 1992-1993.
Courses in Statistics, Computer Science, Machine Learning, Advanced Bayesian Analytics, University of Pennsylvania, 2010-2014.
Certificate Program in Bioinformatics, Penn Institute for Bioinformatics, University of Pennsylvania, 2017-2018.
Permanent linkResidency in Clinical Pathology, Hospital of the University of Pennsylvania, Philadelphia, 1989-1992.
Post-doctoral Research, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, 1991-1993.
Fellowship in Transfusion Medicine, Hospital of the University of Pennsylvania, Philadelphia, 1992-1993.
Courses in Statistics, Computer Science, Machine Learning, Advanced Bayesian Analytics, University of Pennsylvania, 2010-2014.
Certificate Program in Bioinformatics, Penn Institute for Bioinformatics, University of Pennsylvania, 2017-2018.
Description of Itmat Expertise
Dr. Wilson's primary interest is in the neurodegenerative disorder Friedreich ataxia, for which he completed a high-throughput drug screen of >340,000 compounds in the fall of 2008. He is now working with medicinal chemists on the hit compounds. He is also involved in screening random shRNA expressing libraries for small RNAs to be used as therapeutics and biologic tools. The random shRNA expressing libraries and their use is described in PLoS ONE manuscripts that can be accessed openly at the following URLs: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003171http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087390
Selected Publications
Lee, T., Spagnoli, S. T., Lin, D., Gocal, J., Seiler, C., Wilson, R. B. : A Zebrafish Model of Friedreich Ataxia. Manuscript in preparation 2023.Cotticelli, M. G., Xia, S., Truit, R., Doliba, N. M., Rozo, A. V., Tobias, J. W., Lee, T., Chen, J., Napierala, J. S., Napierala, M., Yang, W., Wilson, R. B.: Acute frataxin knockdown in induced pluripotent stem cell-derived cardiomyocytes activates a type I interferon response. Disease Models & Mechanisms 16(5): dmm049497, 2023.
Rodden, L. N., Rummey, C., Kessler, S., Wilson, R. B., Lynch, D. R.: A novel metric for predicting severity of disease features in Friedreich ataxia. Movement Disorders In Press, 2023.
Wang, D., Ho, E. S., Cotticelli, M. G., Xu, P., Napierala, J. S., Hauser, L. A., Napierala, M., Wilson, R. B., Lynch, D. R., Mesaros, C.: Lipid dysfunction predicts the severity of Friedreich’s ataxia using skin fibroblast metabolomic and lipidomic profiling. Journal of Lipid Research In press, 2022 Notes: https://doi.org/10.1016/j.jlr.2022.100255.
Kim, C. Y., Johnson, H., Peltier, S., Spitalnik, S. L., Hod, E. A., Francis, R. O., Hudson, K. E., Stone, E. F., Gordy, D. E., Fu, X. Zimring, J. C., Amireault, P., Buehler, P. W., Wilson, R. B., D'Alessandro, A., Shchepinov, M., Thomas, T. A.: Deuterated Linoleic Acid Attenuates the RBC Storage Lesion in A Mouse Model of Poor RBC Storage. Frontiers in Physiology 13: 868578, 2022.
Yoon, J.-Y., Rosenbaum, J. N., Vergara, N., Cohen, R. B., Wilson, Robert B.: Bayesian Approach to Interpreting Somatic Cancer Sequencing Data: A Case in Point. Journal of Clinical Pathology Page: 206895, 2020.
Cotticelli, M. G., Forestieri, R., Xia, S., Joyasawal, S., Lee, T., Xu, K., Smith, A., Huryn, D., Wilson, R. B.: Identification of a Novel Oleic Acid Analog with Protective Effects in Multiple Cellular Models of Friedreich Ataxia. ACS Chemical Neuroscience 11: 2535−2542, 2020.
Cotticelli, M. G., Xia, S., Lin, D., Lee, T., Lin, D., Terrab, L., Wipf, P., Huryn, D., Wilson, R. B.: Ferroptosis as a novel therapeutic target for Friedreich’s ataxia. Journal of Pharmacology and Experimental Therapeutics 369: 47-54, 2019.
Cotticelli, M. G., Xia, S., Kaur, A., Lin, D., Wang, Y., Ruff, E., Tobias, J. W., Wilson, R. B. : Identification of p38 MAPK as a novel therapeutic target for Friedreich’s ataxia. Scientific Reports 8(1): 5007, 2018.
Seyer L., Greeley N., Foerster D., Strawser C., Gelbard S., Dong Y., Schadt K., Cotticelli M.G., Brocht A., Farmer J., Wilson R.B., Lynch D.R.: Open label pilot study of interferon gamma-1b in Friedreich ataxia. Acta Neurologica Scandinavica 132: 7-15, 2015.