Mortimer M. Civan

faculty photo
Professor of Physiology
Department: Physiology

Contact information
A303 Richards Building
3700 Hamilton Walk
Philadelphia, PA 19104-6085
Office: 2158988773
Education:
A.B.
Columbia College, 1955.
M.D.
Columbia University College of Physicians and Surgeons, 1959.
M.A. (Honorary)
University of Pennsylvania, 1972.
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Description of Research Expertise

I am concerned with salt and water transport across cell membranes and whole epithelial tissues. These issues are essential to understanding regulation of salt and water balance by whole organisms. The laboratory has been studying how changes in intracellular parameters (such as calcium activity, pH, sodium activity, and free energy of hydrolysis of adenosine triphosphate (ATP)) might alter sodium transport. There is also interest in how biochemical modifications of the apical membranes (induced, for example, by phorbol esters) and biophysical alterations of the basolateral membranes might alter net sodium movement.

One major direction is to relate intracellular pH and calcium activity (measured with ion selective microelectrodes) to sodium permeability and intracellular sodium activity (measured with reference micropipets, while applying computer driven trains of voltage pulses). Concurrent studies are in progress ultilizing 31phosphorus and 19fluorine nuclear magnetic resonance (NMR) and patch clamping.

The major model system isthe isolated epithelium from frog skin, an analogue of the human distal nephron which can be studied by a variety of biophysical techniques. Collaborations are also being undertaken with the Glaucoma Unit to study fluid transport
across the ciliary body of the eye, and with the Renal Unit to study nephron tubules directly.

Description of Itmat Expertise

1. Transport across epithelial tissue.
2. Regulation of intraocular pressure in addressing glaucomatous blindness. Study cells, tissues, whole organs and living mice.
3. Transport-independent role of transport proteins in regulating mast cell degranulation, and relevance to asthma and allergic conjunctivitis.

Selected Publications

Wang Zhao, Do Chi Wai, Valiunas Virginijus, Leung Chi Ting, Cheng Angela K W, Clark Abbott F, Wax Martin B, Chatterton Jon E, Civan Mortimer M: Regulation of gap junction coupling in bovine ciliary epithelium. American Journal of Physiology. Cell Physiology 298: C798-806, 2010.

Wang Zhao, Do Chi Wai, Avila Marcel Y, Peterson-Yantorno Kim, Stone Richard A, Gao Zhan-Guo, Joshi Bhalchandra, Besada Pedro, Jeong Lak Shin, Jacobson Kenneth A, Civan Mortimer M: Nucleoside-derived antagonists to A3 adenosine receptors lower mouse intraocular pressure and act across species. Experimental Eye Research 90: 146-54, 2010.

Civan Mortimer M: Transporters beyond transport. Focus on "Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: role of chloride channels". American Journal of Physiology. Cell Physiology. 298: C11-3, 2010.

Calera Mónica R, Wang Zhao, Sanchez-Olea Roberto, Paul David L, Civan Mortimer M, Goodenough Daniel A: Depression of intraocular pressure following inactivation of connexin43 in the nonpigmented epithelium of the ciliary body. Investigative Ophthalmology & Visual Science 50: 2185-93, 2009.

McLaughlin Charles W, Karl Mike O, Zellhuber-McMillan Sylvia, Wang Zhao, Do Chi Wai, Leung Chi Ting, Li Ang, Stone Richard A, Macknight Anthony D C, Civan Mortimer M: Electron probe X-ray microanalysis of intact pathway for human aqueous humor outflow. American Journal of Physiology. Cell Physiology. 295: C1083-91, 2008.

Karl Mike O, Peterson-Yantorno Kim, Civan Mortimer M: Cell-specific differential modulation of human trabecular meshwork cells by selective adenosine receptor agonists. Experimental Eye Research 84: 126-34, 2007.

Wang Zhao, Do Chi Wai, Avila Marcel Y, Stone Richard A, Jacobson Kenneth A, Civan Mortimer M: Barrier qualities of the mouse eye to topically applied drugs. Experimental Eye Research 85: 105-12, 2007.

McLaughlin Charles W, Zellhuber-McMillan Sylvia, Macknight Anthony D C, Civan Mortimer M: Electron microprobe analysis of rabbit ciliary epithelium indicates enhanced secretion posteriorly and enhanced absorption anteriorly. American Journal of Physiology. Cell Physiology 293: C1455-66, 2007.

Do, C.W. and Civan, M.M.: Swelling-Activated Cl- Channels in Aqueous Humor Formation: On the One Side and the Other. Acta Physiol. Scand. 187: 345–352, 2006.

Do Chi Wai, Peterson-Yantorno Kim, Civan Mortimer M: Swelling-activated Cl- channels support Cl- secretion by bovine ciliary epithelium. Investigative Ophthalmology & Visual Science 47: 2576-82, 2006.

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Last updated: 09/01/2010
The Trustees of the University of Pennsylvania