Simon F Lacey

faculty photo
Adjunct Associate Professor of Pathology and Laboratory Medicine
Director, Translational and Correlative Studies Laboratory (TCSL), Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Department: Pathology and Laboratory Medicine

Contact information
SPE South Tower 9-103
3400 Civic Center Blvd, Building 421
Philadelphia, PA 19104
Education:
BSc. (Biochemistry)
Imperial College, London University, UK, 1987.
Ph.D. (Virology)
National Institute for Medical Research, Mill Hill, London, U.K., 1990.
Permanent link
 

Description of Itmat Expertise

T-cell immunology
Tumor immunity
CAR-T therapy
Cytokines and biomarkers
polyomaviruses
Viral immunology

Selected Publications

Teachey David T, Lacey Simon F, Shaw Pamela A, Melenhorst J Joseph, Maude Shannon L, Frey Noelle, Pequignot Edward, Gonzalez Vanessa E, Chen Fang, Finklestein Jeffrey, Barrett David M, Weiss Scott L, Fitzgerald Julie C, Berg Robert A, Aplenc Richard, Callahan Colleen, Rheingold Susan R, Zheng Zhaohui, Rose-John Stefan, White Jason C, Nazimuddin Farzana, Wertheim Gerald, Levine Bruce L, June Carl H, Porter David L, Grupp Stephan A: Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T cell Therapy for Acute Lymphoblastic Leukemia. Cancer discovery Apr 2016.

Chen Fang, Teachey David T, Pequignot Edward, Frey Noelle, Porter David, Maude Shannon L, Grupp Stephan A, June Carl H, Melenhorst Jan J, Lacey Simon F: Measuring IL-6 and sIL-6R in serum from patients treated with tocilizumab and/or siltuximab following CAR T cell therapy. Journal of immunological methods Apr 2016.

Fraietta Joseph A, Beckwith Kyle A, Patel Prachi R, Ruella Marco, Zheng Zhaohui, Barrett David M, Lacey Simon F, Melenhorst Jan Joseph, McGettigan Shannon E, Cook Danielle R, Zhang Changfeng, Xu Jun, Do Priscilla, Hulitt Jessica, Kudchodkar Sagar B, Cogdill Alexandria P, Gill Saar, Porter David L, Woyach Jennifer A, Long Meixiao, Johnson Amy J, Maddocks Kami, Muthusamy Natarajan, Levine Bruce L, June Carl H, Byrd John C, Maus Marcela V: Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia. Blood 127(9): 1117-27, Mar 2016.

Ruella Marco, Kenderian Saad S, Shestova Olga, Fraietta Joseph A, Qayyum Sohail, Zhang Qian, Maus Marcela V, Liu Xiaobin, Nunez-Cruz Selene, Klichinsky Michael, Kawalekar Omkar U, Milone Michael, Lacey Simon F, Mato Anthony, Schuster Stephen J, Kalos Michael, June Carl H, Gill Saar, Wasik Mariusz A: The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma. Clinical cancer research : an official journal of the American Association for Cancer Research Jan 2016.

Sotillo Elena, Barrett David M, Black Kathryn L, Bagashev Asen, Oldridge Derek, Wu Glendon, Sussman Robyn, Lanauze Claudia, Ruella Marco, Gazzara Matthew R, Martinez Nicole M, Harrington Colleen T, Chung Elaine Y, Perazzelli Jessica, Hofmann Ted J, Maude Shannon L, Raman Pichai, Barrera Alejandro, Gill Saar, Lacey Simon F, Melenhorst Jan J, Allman David, Jacoby Elad, Fry Terry, Mackall Crystal, Barash Yoseph, Lynch Kristen W, Maris John M, Grupp Stephan A, Thomas-Tikhonenko Andrei: Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy. Cancer discovery 5(12): 1282-95, Dec 2015.

Garfall Alfred L, Maus Marcela V, Hwang Wei-Ting, Lacey Simon F, Mahnke Yolanda D, Melenhorst J Joseph, Zheng Zhaohui, Vogl Dan T, Cohen Adam D, Weiss Brendan M, Dengel Karen, Kerr Naseem D S, Bagg Adam, Levine Bruce L, June Carl H, Stadtmauer Edward A: Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma. The New England journal of medicine 373(11): 1040-7, Sep 2015.

Porter David L, Hwang Wei-Ting, Frey Noelle V, Lacey Simon F, Shaw Pamela A, Loren Alison W, Bagg Adam, Marcucci Katherine T, Shen Angela, Gonzalez Vanessa, Ambrose David, Grupp Stephan A, Chew Anne, Zheng Zhaohui, Milone Michael C, Levine Bruce L, Melenhorst Jan J, June Carl H: Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Science translational medicine 7(303): 303ra139, Sep 2015.

Melenhorst J Joseph, Lacey Simon F, Bedoya Felipe: Chimeric antigen receptor T cells: Self-replicating drugs for cancer. Current drug targets Aug 2015.

Rapoport Aaron P, Stadtmauer Edward A, Binder-Scholl Gwendolyn K, Goloubeva Olga, Vogl Dan T, Lacey Simon F, Badros Ashraf Z, Garfall Alfred, Weiss Brendan, Finklestein Jeffrey, Kulikovskaya Irina, Sinha Sanjoy K, Kronsberg Shari, Gupta Minnal, Bond Sarah, Melchiori Luca, Brewer Joanna E, Bennett Alan D, Gerry Andrew B, Pumphrey Nicholas J, Williams Daniel, Tayton-Martin Helen K, Ribeiro Lilliam, Holdich Tom, Yanovich Saul, Hardy Nancy, Yared Jean, Kerr Naseem, Philip Sunita, Westphal Sandra, Siegel Don L, Levine Bruce L, Jakobsen Bent K, Kalos Michael, June Carl H: NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma. Nature medicine 21(8): 914-21, Aug 2015.

Maude Shannon L, Frey Noelle, Shaw Pamela A, Aplenc Richard, Barrett David M, Bunin Nancy J, Chew Anne, Gonzalez Vanessa E, Zheng Zhaohui, Lacey Simon F, Mahnke Yolanda D, Melenhorst Jan J, Rheingold Susan R, Shen Angela, Teachey David T, Levine Bruce L, June Carl H, Porter David L, Grupp Stephan A: Chimeric antigen receptor T cells for sustained remissions in leukemia. The New England journal of medicine 371(16): 1507-17, Oct 2014.

back to top
Last updated: 11/03/2016
The Trustees of the University of Pennsylvania