Simon F Lacey
Adjunct Associate Professor of Pathology and Laboratory Medicine
Director, Translational and Correlative Studies Laboratory (TCSL), Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Department: Pathology and Laboratory Medicine
Contact information
SPE South Tower 9-103
3400 Civic Center Blvd, Building 421
Philadelphia, PA 19104
3400 Civic Center Blvd, Building 421
Philadelphia, PA 19104
Email:
simon.lacey@uphs.upenn.edu
simon.lacey@uphs.upenn.edu
Publications
Education:
BSc. (Biochemistry)
Imperial College, London University, UK, 1987.
Ph.D. (Virology)
National Institute for Medical Research, Mill Hill, London, U.K., 1990.
BSc. (Biochemistry)
Imperial College, London University, UK, 1987.
Ph.D. (Virology)
National Institute for Medical Research, Mill Hill, London, U.K., 1990.
Post-Graduate Training
Post-doctoral Researcher, Department of Surgical Virology, Duke University Medical Center, Durham, North Carolina, 1994-1998.
Senior Research Fellow, Department of Hematology Research, City of Hope National Medical Center, Duarte, CA , 1998-1999.
Assistant Research Scientist, Department of Hematology Research, City of Hope National Medical Center, Duarte, CA, 1999-1999.
Assistant Research Scientist, Laboratory of Vaccine Research, Department of Virology, Beckman Research Institute of the City of Hope National Medical Center, Duarte, CA, 1999-2005.
Permanent linkPost-doctoral Researcher, Department of Surgical Virology, Duke University Medical Center, Durham, North Carolina, 1994-1998.
Senior Research Fellow, Department of Hematology Research, City of Hope National Medical Center, Duarte, CA , 1998-1999.
Assistant Research Scientist, Department of Hematology Research, City of Hope National Medical Center, Duarte, CA, 1999-1999.
Assistant Research Scientist, Laboratory of Vaccine Research, Department of Virology, Beckman Research Institute of the City of Hope National Medical Center, Duarte, CA, 1999-2005.
Description of Itmat Expertise
T-cell immunologyTumor immunity
CAR-T therapy
Cytokines and biomarkers
polyomaviruses
Viral immunology
Selected Publications
Cohen Adam D, Garfall Alfred L, Stadtmauer Edward A, Melenhorst J Joseph, Lacey Simon F, Lancaster Eric, Vogl Dan T, Weiss Brendan M, Dengel Karen, Nelson Annemarie, Plesa Gabriela, Chen Fang, Davis Megan M, Hwang Wei-Ting, Young Regina M, Brogdon Jennifer L, Isaacs Randi, Pruteanu-Malinici Iulian, Siegel Don L, Levine Bruce L, June Carl H, Milone Michael C: B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma. The Journal of clinical investigation 130, Mar 2019.Gofshteyn Jacqueline S, Shaw Pamela A, Teachey David T, Grupp Stephan A, Maude Shannon, Banwell Brenda, Chen Fang, Lacey Simon F, Melenhorst Jan J, Edmonson MacKenzie J, Panzer Jessica, Barrett David M, McGuire Jennifer L: Neurotoxicity after CTL019 in a pediatric and young adult cohort. Annals of neurology 84(4): 537-546, Oct 2018.
Ruella Marco, Xu Jun, Barrett David M, Fraietta Joseph A, Reich Tyler J, Ambrose David E, Klichinsky Michael, Shestova Olga, Patel Prachi R, Kulikovskaya Irina, Nazimuddin Farzana, Bhoj Vijay G, Orlando Elena J, Fry Terry J, Bitter Hans, Maude Shannon L, Levine Bruce L, Nobles Christopher L, Bushman Frederic D, Young Regina M, Scholler John, Gill Saar I, June Carl H, Grupp Stephan A, Lacey Simon F, Melenhorst J Joseph: Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Nature medicine 24(10): 1499-1503, Oct 2018.
Svoboda Jakub, Rheingold Susan R, Gill Saar I, Grupp Stephan A, Lacey Simon F, Kulikovskaya Irina, Suhoski Megan M, Melenhorst J Joseph, Loudon Brandon, Mato Anthony R, Nasta Sunita Dwivedy, Landsburg Daniel J, Youngman Matthew R, Levine Bruce L, Porter David L, June Carl H, Schuster Stephen J: Nonviral RNA chimeric antigen receptor-modified T cells in patients with Hodgkin lymphoma. Blood 132(10): 1022-1026, Sep 2018.
Ghassemi Saba, Nunez-Cruz Selene, O'Connor Roddy S, Fraietta Joseph A, Patel Prachi R, Scholler John, Barrett David M, Lundh Stefan M, Davis Megan M, Bedoya Felipe, Zhang Changfeng, Leferovich John, Lacey Simon F, Levine Bruce L, Grupp Stephan A, June Carl H, Melenhorst J Joseph, Milone Michael C: Reducing Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells. Cancer immunology research 6(9): 1100-1109, Sep 2018.
Kloss Christopher C, Lee Jihyun, Zhang Aaron, Chen Fang, Melenhorst Jan Joseph, Lacey Simon F, Maus Marcela V, Fraietta Joseph A, Zhao Yangbing, June Carl H: Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication. Molecular therapy : the journal of the American Society of Gene Therapy 26(7): 1855-1866, Jul 2018.
Kong Weimin, Lacey Simon F, Melenhorst Jan Joseph, Fraietta Joseph A: Biomarkers in chimeric antigen receptor T-cell therapy. Biomarkers in medicine 12(5): 415-418, May 2018.
Fraietta Joseph A, Lacey Simon F, Orlando Elena J, Pruteanu-Malinici Iulian, Gohil Mercy, Lundh Stefan, Boesteanu Alina C, Wang Yan, O'Connor Roddy S, Hwang Wei-Ting, Pequignot Edward, Ambrose David E, Zhang Changfeng, Wilcox Nicholas, Bedoya Felipe, Dorfmeier Corin, Chen Fang, Tian Lifeng, Parakandi Harit, Gupta Minnal, Young Regina M, Johnson F Brad, Kulikovskaya Irina, Liu Li, Xu Jun, Kassim Sadik H, Davis Megan M, Levine Bruce L, Frey Noelle V, Siegel Donald L, Huang Alexander C, Wherry E John, Bitter Hans, Brogdon Jennifer L, Porter David L, June Carl H, Melenhorst J Joseph: Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nature medicine 24(5): 563-571, May 2018.
Garfall Alfred L, Stadtmauer Edward A, Hwang Wei-Ting, Lacey Simon F, Melenhorst Jan Joseph, Krevvata Maria, Carroll Martin P, Matsui William H, Wang Qiuju, Dhodapkar Madhav V, Dhodapkar Kavita, Das Rituparna, Vogl Dan T, Weiss Brendan M, Cohen Adam D, Mangan Patricia A, Ayers Emily C, Nunez-Cruz Selene, Kulikovskaya Irina, Davis Megan M, Lamontagne Anne, Dengel Karen, Kerr Naseem Ds, Young Regina M, Siegel Donald L, Levine Bruce L, Milone Michael C, Maus Marcela V, June Carl H: Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma. JCI insight 3(8), Apr 2018.
Guedan Sonia, Posey Avery D, Shaw Carolyn, Wing Anna, Da Tong, Patel Prachi R, McGettigan Shannon E, Casado-Medrano Victoria, Kawalekar Omkar U, Uribe-Herranz Mireia, Song Decheng, Melenhorst J Joseph, Lacey Simon F, Scholler John, Keith Brian, Young Regina M, June Carl H: Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation. JCI insight 3(1), Jan 2018.