faculty photo

Struan F.A. Grant

Associate Professor of Pediatrics
Department: Pediatrics

Contact information
Divisions of Human Genetics and Endocrinology
Children’s Hospital of Philadelphia Research Institute
Rm 1102D, 3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: 267-426-2795
Fax: 215-590-1258
BSc (Genetics)
University of Aberdeen, UK, 1991.
PhD (Genetics)
University of Aberdeen, UK, 1995.
Permanent link

Description of Research Expertise

I have been conducting human genomics research for over 20 years. The highlights of my career are the discovery of the polymorphic Sp1 site in the COL1A1 gene and its association with osteoporosis, the identification of variation in the TCF7L2 gene playing a key role in conferring type 2 diabetes risk and providing leadership in an international genetics effort to characterize genes influencing birth weight and common childhood obesity risk. I have also previously played a role in uncovering genes involved in other traits, including cleft lip with or without palate, scoliosis, inflammatory bowel disease, autism, ADHD, head circumference, intracranial volume, myocardial infarction, pediatric eosinophilic esophagitis, type 1 diabetes, asthma, multiple sclerosis and neuroblastoma.

My current work continues to primarily investigate disease genomics, with a specific focus on pediatrics. Utilizing high-throughput genotyping and sequencing technologies, combined with statistical and bioinformatic approaches, my goals include unraveling genomic puzzles related to childhood obesity, pediatric bone strength determination, early onset diabetes and cancer. These phenotypes are known to be strongly determined by genetic factors; however, resolving genomic contributors to such complex phenotypes in adults has been impeded by interaction with strong environmental factors. Distillation of the genomic architecture in these complex traits should be easier to determine in children, where the relatively short period of their lifetime limits the impact of environmental exposure. Given the global prevalence of such diseases, prevention of these disorders and their serious complications must be addressed in order to reduce individual morbidity and the economic burden on society.

Funding as PI:
R01 HD056465, R01 HD058886, R01 DK085212, Pennsylvania Department of Health CURE award, Daniel B. Burke Endowed Chair for Diabetes Research

Research Team:
Alessandra Chesi, Diana L. Cousminer, Kenyaita M. Hodge, Matthew E. Johnson, Michelle E. Leonard, Sumei Lu, Elisabetta Manduchi, Rajashree Mishra, Ursula W. Parlin, Qianghua Xia

Former members: Kevin J. Basile, Sandra Deliard, Vanessa C. Guy, Brian T. Johnston, Jianhua Zhao

Selected Publications

J.A. Mitchell*, A. Chesi*, S.E. McCormack, S.M. Roy, D.L. Cousminer, H.J. Kalkwarf, J.M. Lappe, V. Gilsanz, S.E. Oberfield, J.A. Shepherd, A. Kelly, B.S. Zemel* and S.F.A. Grant*: Rare EN1 variants and pediatric bone mass. Journal of Bone and Mineral Research Epub ahead of print, March 2016 Notes: *equal contribution.

J.F. Felix*, J.P. Bradfield*, C. Monnereau*, R.J.P. van der Valk*, E. Stergiakouli, A. Chesi, R. Gaillard, B. Feenstra, E. Thiering, E. Kreiner-Møller, A. Mahajan, N. Pitkänen, R. Joro, A. Cavadino, V. Huikari, S. Franks, M.M. Groen-Blokhuis, D.L. Cousminer, J.A. Marsh, T. Lehtimäki, J.A. Curtin, J. Vioque, T.S. Ahluwalia, R. Myhre, T.S. Price, N. Vilor-Tejedor, L. Yengo, N. Grarup, I. Ntalla, W. Ang, M. Atalay, H. Bisgaard, A.I. Blakemore, A. Bonnefond, L. Carstensen, Bone Mineral Density in Childhood Study (BMDCS) Consortium, Early Genetics and Lifecourse Epidemiology (EAGLE) consortium, J. Eriksson, C. Flexeder, L. Franke, F. Geller, M. Geserick, A.L. Hartikainen, C.M. A. Haworth, J.N. Hirschhorn, A. Hofman, J.C. Holm, M. Horikoshi, J.J. Hottenga, J. Huang, H.N. Kadarmideen, M. Kähönen, W. Kiess, H.M. Lakka, T.A. Lakka, A.M. Lewin, L. Liang, L.P. Lyytikäinen, B. Ma, P. Magnus, S.E. McCormack, G. McMahon, F.D. Mentch, C.M. Middeldorp, C.S. Murray, K. Pahkala, T.H. Pers, R. Pfäffle, D.S. Postma, C. Power, A. Simpson, V. Sengpiel, C.M.T. Tiesler, M. Torrent, A.G. Uitterlinden, J.B. van Meurs, R. Vinding, J. Waage, J. Wardle, E. Zeggini, B.S. Zemel, G.V. Dedoussis, O. Pedersen, P. Froguel, J. Sunyer, R. Plomin, B. Jacobsson, T. Hansen, J.R. Gonzalez, A. Custovic, O.T. Raitakari, C.E. Pennell, E. Widén, D.I. Boomsma, G.H. Koppelman, S. Sebert, M.R. Järvelin, E. Hyppönen, M.I. McCarthy, V. Lindi, N. Harri, A. Körner, K. Bønnelykke, J. Heinrich, M. Melbye, F. Rivadeneira, H. Hakonarson, S.M. Ring, G. Davey Smith, T.I.A. Sørensen, N.J. Timpson*, S.F.A. Grant* and Vincent W.V. Jaddoe* for the Early Growth Genetics (EGG) Consortium: Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics 25: 389-403, 2016 Notes: *equal contribution.

J. Tyrrell, R.C. Richmond, T.M. Palmer, B. Feenstra, J. Rangarajan, S. Metrustry, A. Cavadino, L. Paternoster, L.L. Armstrong, N.M.G. De Silva, A.R. Wood, M. Horikoshi, F. Geller, R. Myhre, J.P. Bradfield, E. Kreiner-Møller, V. Huikari, J.N. Painter, J.J. Hottenga, C. Allard, D.J. Berry, L. Bouchard, S. Das, D.M. Evans, H. Hakonarson, M.G. Hayes, J. Heikkinen, A. Hofman, B. Knight, P.A. Lind, M.I. McCarthy, G. McMahon, S.E. Medland, M. Melbye, A.P. Morris, M. Nodzenski, C. Reichetzeder, S.M. Ring, S. Sebert, V. Sengpiel, T.I.A. Sørensen, G. Willemsen, E.J.C. de Geus, N.G. Martin, T.D. Spector, C. Power, M.R. Järvelin, H. Bisgaard, S.F.A. Grant, E.A. Nohr, V.W. Jaddoe, B. Jacobsson, J.C. Murray, B. Hocher, A.T. Hattersley, D.M. Scholtens, G. Davey Smith, M.F. Hivert, J.F. Felix, E. Hyppönen, W.L. Lowe Jr, T.M. Frayling*, D.A. Lawlor* and R.M. Freathy* for the Early Growth Genetics (EGG) Consortium: Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA 315: 1129-1140, 2016 Notes: *equal contribution.

Y. Chen*, C. Chen*, Z. Zhang, C.C. Liu, M.E. Johnson, C.A. Espinoza, L.E. Edsall, B. Ren, X.J. Zhou, S.F.A. Grant, A.D. Wells* and L. Chen*: DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions. Nucleic Acids Research 43: 1268-1282, 2015 Notes: *equal contribution.

A. Chesi, J.A. Mitchell, H.J. Kalkwarf, J.P. Bradfield, J.M. Lappe, S.E. McCormack, V. Gilsanz, S.E. Oberfield, H. Hakonarson, J.A. Shepherd, A. Kelly, B.S. Zemel* and S.F.A. Grant*: A Trans-ethnic Genome-wide Association Study Identifies Gender Specific Loci Influencing Pediatric aBMD and BMC at the Distal Radius. Human Molecular Genetics 24: 5053-9, 2015 Notes: *equal contribution.

M. Horikoshi*, H. Yaghootkar*, D.O. Mook-Kanamori*, U. Sovio, H.R. Taal, B.J. Hennig, J.P Bradfield, B. St Pourcain, D.M. Evans, P. Charoen, M. Kaakinen, D.L. Cousminer, T. Lehtimäki, E. Kreiner-Møller, N.M. Warrington, M. Bustamante, B. Feenstra, D.J. Berry, E. Thiering, T. Pfab, S.J. Barton, B.M. Shields, M. Kerkhof, E.M. van Leeuwen, A.J. Fulford, Z. Kutalik, J.H. Zhao, M. den Hoed, A. Mahajan, V. Lindi, L.K. Goh, J.J. Hottenga, Y. Wu, O.T. Raitakari, M.N. Harder, A. Meirhaeghe, I. Ntalla, R.M. Salem, K.A. Jameson, K. Zhou, D.M. Monies, V. Lagou, M. Kirin, J. Heikkinen, L.S. Adair, F.S. Alkuraya, A. Al-Odaib, P. Amouyel, E.A. Andersson, A.J. Bennett, A.I.F. Blakemore, J.L. Buxton, J. Dallongeville, S. Das, E.J.C. de Geus, X. Estivill, C. Flexeder, P. Froguel, F. Geller, K.M. Godfrey, F. Gottrand, C.J. Groves, T. Hansen, J.N. Hirschhorn, A. Hofman, M.V. Hollegaard, D.M. Hougaard, E. Hyppönen, H.M. Inskip, A. Isaacs, T. Jørgensen, C. Kanaka-Gantenbein, J.P. Kemp, W. Kiess, T.O. Kilpeläinen, N. Klopp, B.A. Knight, C.W. Kuzawa, G. McMahon, J.P. Newnham, H. Niinikoski, B.A. Oostra, L. Pedersen, D.S. Postma, S.M. Ring, F. Rivadeneira, N.R. Robertson, S. Sebert, O. Simell, T. Slowinski, C.M.T. Tiesler, A. Tönjes, A. Vaag, J.S. Viikari, J.M. Vink, N.H. Vissing, N.J. Wareham, G. Willemsen, D.R. Witte, H. Zhang, J. Zhao, The Meta-Analyses of Glucose- and Insulin-related traits Consortium (MAGIC), J.F. Wilson, M. Stumvoll, A.M. Prentice, B.F. Meyer, E.R. Pearson, C.A.G. Boreham, C. Cooper, M.W. Gillman, G.V. Dedoussis, L.A. Moreno, O. Pedersen, M. Saarinen, K.L. Mohlke, D.I. Boomsma, S.M. Saw, T.A. Lakka, A. Körner, R.J.F. Loos, K.K. Ong, P. Vollenweider, C.M. van Duijn, G.H. Koppelman, A.T. Hattersley, J.W. Holloway, B. Hocher, J. Heinrich, C. Power, M. Melbye, M. Guxens, C.E. Pennell, K. Bønnelykke, H. Bisgaard, J.G. Eriksson, E. Widén, H. Hakonarson, A.G. Uitterlinden, A. Pouta, D.A. Lawlor, G. Davey Smith, T.M. Frayling, M.I. McCarthy*, S.F.A. Grant*, V.W.V. Jaddoe*, M.R. Jarvelin*, N.J. Timpson*, I. Prokopenko* and R.M. Freathy* for the Early Growth Genetics (EGG) Consortium: New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nature Genetics 45: 76-82, 2013 Notes: *equal contribution.

J.P. Bradfield*, H.R. Taal*, N.J Timpson, A. Scherag, C. Lecoeur, N.M. Warrington, E. Hypponen, C. Holst, B. Valcarcel, E. Thiering, R.M. Salem, F.R. Schumacher, D.L. Cousminer, P.M.A. Sleiman, J. Zhao, R.I. Berkowitz, K.S. Vimaleswaran, I. Jarick, C.E. Pennell, D.M. Evans, B. St Pourcain, D.J. Berry, D.O. Mook-Kanamori, A. Hofman, F. Rivadeneira, A.G. Uitterlinden, C.M. van Duijn, R.J.P. van der Valk, J.C. de Jongste, D.S. Postma, D.I. Boomsma, W.J. Gauderman, M.T. Hassanein, C.M. Lindgren, R. Mägi, C.A.G. Boreham, C.E. Neville, L.A. Moreno, P. Elliott, A. Pouta, A.L. Hartikainen, M. Li, O. Raitakari, T. Lehtimäki, J.G Eriksson, A. Palotie, J. Dallongeville, S. Das, P. Deloukas, G. McMahon, S.M. Ring, J.P. Kemp, J.L. Buxton, A.I.F. Blakemore, M. Bustamante, M. Guxens, J.N. Hirschhorn, M.W. Gillman, E. Kreiner-Møller, H. Bisgaard, F.D. Gilliland, J. Heinrich, E. Wheeler, I. Barroso, S. O’Rahilly, A. Meirhaeghe, T.I.A. Sørensen, C. Power, L.J. Palmer, A. Hinney, E. Widen, I.S. Farooqi, M.I. McCarthy, P. Froguel, D. Meyre, J. Hebebrand, M.R. Jarvelin, V.W.V. Jaddoe, G. Davey Smith, H. Hakonarson and S.F.A. Grant for the Early Growth Genetics (EGG) Consortium: A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics 44: 526–531, 2012 Notes: *equal contribution.

H. Hakonarson*, S.F.A. Grant*, J.P. Bradfield*, L. Marchand, C.E. Kim, J.T. Glessner, R. Grabs, T. Casalunovo, S.P. Taback, E.C. Frackelton, M.L. Lawson, L.J. Robinson, R. Skraban, Y. Lu, R.M. Chiavacci, C.A. Stanley, S.E. Kirsch, E.F. Rappaport, J.S. Orange, D.S. Monos, M. Devoto, H. Qu and C. Polychronakos: A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature 448(7153): 591-4, 2007 Notes: *equal contribution.

S.F.A. Grant, G. Thorleifsson, I. Reynisdottir, R. Benediktsson, A. Manolescu, J. Sainz, A. Helgason, H. Stefansson, V. Emilsson, A. Helgadottir, U. Styrkarsdottir, K.P. Magnusson, G. B. Walters, E. Palsdottir, T. Jonsdottir, T. Gudmundsdottir, A. Gylfason, J. Saemundsdottir, R.L. Wilensky, M.P. Reilly, D.J. Rader, Y. Bagger, C. Christiansen, V.Gudnason, G. Sigurdsson, U. Thorsteinsdottir, J.R. Gulcher, A. Kong and K. Stefansson : Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nature Genetics 38(3): 320-3, 2006 Notes: TOP COVER STORY.

S.F.A. Grant, D.M. Reid, G. Blake, R. Herd, I. Fogelman and S.H. Ralston: Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene. Nature Genetics 14(2): 203-5, 1996.

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Last updated: 05/24/2016
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