The Arany lab studies cardiovascular metabolism, with a focus on the vasculature and striated muscles. We take a multidisciplinary approach, spanning from molecular biology and numerous ‘omic approaches to mouse models and human clinical studies. The objective is to make fundamental discoveries about cardiovascular metabolism and translate the findings to the clinic.
Metabolism, angiogenesis, vasculature, PGC-1alpha, mitochondria, exercise, muscle, heart, endothelium
Examples of ongoing projects include:
1. Understanding metabolism in the vasculature, using state-of-the-art metabolomic tools. Much is known of metabolism in cancer cells, and in parenchymal cells, but the role of metabolism in vascular cell biology has received little attention.
2. CRISPR/Cas9 genome editing to identify novel genes that regulate vascular metabolism.
3. Using the powerful metabolic regulator PGC-1alpha as a discovery platform to probe the regulation of metabolism and its coordination with vessel biology in striated muscles.
4. Genetic studies of peripartum cardiomyopathy (PPCM), a disease that we now recognize as vascular in nature.
5. Using mouse models to evaluate the role of the vasculature and metabolism in the development of, and protection from, muscle dystrophy, in particular Duchenne Muscle Dystrophy.
6. Clinical echocardiographic and biomarker studies of cardiac function in preeclampsia, a disease that we now recognize as being significantly vasculotoxic to the heart.
Zoltan Arany, PI
Jian Li, MD PhD, Lab manager
Shogo Wada, PhD, Postdoctoral fellow
Atsushi Hoshino, MD PhD, Postdoctoral fellow
Cholsoon Jang, PhD student
Laura Liu, PhD student
Zhipeng Hu, visiting PhD student
Boa Kim, Postdoctoral fellow
James Rhee, MD PhD, Instructor
Mun Chun Chan, PhD, Postdoctoral fellow
Lab Contact Information
For more details see www.aranylab.org
Arany Zoltan P, Walker Christopher M, Wang Lin: Case records of the Massachusetts General Hospital. Case 22-2014. A 40-year-old woman with postpartum dyspnea and hypoxemia. The New England journal of medicine 371(3): 261-9, Jul 2014.
Sawada Naoki, Jiang Aihua, Takizawa Fumihiko, Safdar Adeel, Manika Andre, Tesmenitsky Yevgenia, Kang Kyu-Tae, Bischoff Joyce, Kalwa Hermann, Sartoretto Juliano L, Kamei Yasutomi, Benjamin Laura E, Watada Hirotaka, Ogawa Yoshihiro, Higashikuni Yasutomi, Kessinger Chase W, Jaffer Farouc A, Michel Thomas, Sata Masataka, Croce Kevin, Tanaka Rica, Arany Zolt: Endothelial PGC-1α mediates vascular dysfunction in diabetes. Cell metabolism 19(2): 246-58, Feb 2014.
Chan Mun Chun, Rowe Glenn C, Raghuram Srilatha, Patten Ian S, Farrell Caitlin, Arany Zolt: Post-natal induction of PGC-1α protects against severe muscle dystrophy independently of utrophin. Skeletal muscle 4(1): 2, 2014.
Jang C, Arany Z: Metabolism: Sweet enticements to move. Nature 500(7463): 409-11, Aug 2013.
Haq R, Shoag S, Andreu-Perez P, Yokoyama S, Edelman H, Hurley AD, Nellore A, Wargo JA, Song JS, Fisher DE*, Arany Z*, Widlund HR*: Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF. Cancer Cell 23(3): 302-15, Mar 2013 Notes: *co-corresponding authors editorials in Nature Reviews Cancer, and Pigment Cell & Melanoma Research.
Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis N, Farrel C, Amos CI, Wi Q, Lee JE, Zhang J, Kupper TS, Qureshi AA, Cui R, Han J, Fisher DE, Arany Z: PGC-1 coactivators regulate MITF and the tanning response. Molecular Cell 49(1): 145-57, Jan 2013 Notes: editorials in Nature Reviews Cancer, and Pigment Cell & Melanoma Research.
Rowe GC, Patten IS, Zsengeller Z, El-Khoury R, Okutsu M, Bampoh S, Koulisis N, Farrell C, Hirshman M, Yan Z, Goodyear L, Rustin P, Arany Z: Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle. Cell Reports 3(5): 1449-56, May 2013.
Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood , Hess P, Farrell C, Koulisis N , Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z: Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature 485(7398): 333-8, May 2012.
Chinsomboon J, Ruas J, Gupta RK, Thom R, Shoag J, Rowe GC, Sawada N, Raghuram S, Arany Z: The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America 106(50): 21401-6, Dec 2009.
Arany Z, Foo S-Y, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, Baek KH, Rosenzweig A, Spiegelman BM: HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature 451(7181): 1008-12, Feb 2008 Notes: editorials in NEJM, Dev. Cell, and Science STK.
Rowe Glenn C, Safdar Adeel, Arany Zolt: Running forward: new frontiers in endurance exercise biology. Circulation 129(7): 798-810, Feb 2014.
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Last updated: 10/20/2014
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