Chronobiology at Penn School of Medicine
Bridging Clocks to Medicine : Promoting innovative research in basic circadian biology and how it impacts all aspects of physiology and health
Virtually all organisms display circadian (~24 hour) rhythms of behavior and physiology that have facilitated adaptation to the day:night cycle. These rhythms are driven by endogenous circadian clocks, which restrict or promote various physiological phenomena at specific times of day. For instance, clocks in humans ensure that sleep occurs at night, body temperature is highest in the evening and cortisol peaks following morning awakening. The past two decades have seen major advances in our understanding of the science of circadian rhythms (chronobiology). These studies are also highlighting the biomedical importance of rhythms, with disrupted rhythms linked to aging as well as to metabolic, psychiatric and other disorders. Treatment of many diseases might also benefit from an approach that takes time-of-day into account.
The Chronobiology Program at Penn was created in 2013 to bring together researchers working in the very diverse areas impacted by circadian clocks. The goal is to strengthen our overall understanding of how biological timing impacts organismal function, and to promote the translation of laboratory findings to clinical implementation. Our participating faculty members are leaders in their fields, and their collective research interests encompass a vast spectrum of biomedical science, from neurobiology to metabolism to cardiovascular disease and cancer. The program hosts monthly research meetings, which bring together researchers working in these different areas. Other activities sponsored by the program include an annual retreat and regional conferences. In addition, the program provides travel awards, which allow trainees in this area to present their work at national/international conferences. We are also recruiting new faculty in an effort to further enhance the already strong circadian and sleep communities at Penn.
Sleep-Chronobiology joint Seminar Series
Mary Harrington, Ph.D.
Tippet Professor in the Life Sciences (Psychology)
"Neurobiology of Fatigue"
Friday, October 27, 2017, 12 pm, Smilow 12-146AB
Next Clock Meeting
Monday, September 25, 4-5 pm, SCTR 10-146
Priya Panikker (Elefant Lab, Drexel University):
"Restoring Tip60 HAT/HDAC2 balance in the AD Drosophila brain reinstates cognitive function"
Namni Goel and Kelly Allison:
"Effects of a Daytime vs Delayed Eating Schedule on Weight, Metabolism and Circadian Rhythms in Normal Weight Adults"
Mitch Lazar and Sarah Tishkoff elected to the National Academy of Sciences
Congratulations Mitch and Sarah!