Welcome
The mission of our laboratory is to develop new therapies in cancer and regenerative medicine by targeting the tissue microenvironment.
As a seed needs the correct light, water, and soil to germinate and grow, most malignant diseases require a highly specialized environment to initiate, develop and progress. Interactive stromal cells including vasculature, immune cells, and stem cells, create a tissue-specific microenvironment with abundant soluble factors and matrix conducive to cancer progression and post-injury tissue repair. The goal of our laboratory is to decipher the key mechanisms that control the formation of a body-hostile, disease-friendly tissue microenvironment. By targeting the tissue microenvironment we will be able to penetrate the microenvironment allowing host defenses and situation-specific therapies to target the diseased tissue with great efficacy.
Contact Us

Fan Laboratory
Department of Radiation Oncology
University of Pennsylvania
3400 Civic Center Blvd
Smilow Center for Translational Research
Rm 8-132 (Office); Rm 8-167 (Lab)
Philadelphia, PA 19104
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