Committee Research Protocol Approval
It is an Institutional requirement that every investigator obtain and document updated approval of their animal research plan by the Institutional Animal Care and Use Committee (IACUC) as well as the Institutional Biosafety Committee (IBC) for DNA, ES cell and RNA injection projects prior to using the Transgenic & Chimeric Mouse Facility.
It is the policy of the Core that no injection date will be assigned until the DNA to be injected is submitted, the service request has been completed Online and the required documents have been provided. The assigned injection date for the RNA mix as well as ES cell will be coordinated with the investigator
All information provided by the investigator concerning the research project are treated with the utmost confidentiality. No subject related material will be released to or shared with anyone without a written consent of the principal investigator.
For those investigators preparing to submit grant proposals to funding agencies, the Core can provide a letter stating our readiness to make transgenic, chimeric and/or genome-edited mice for your project.
We request that any scientific publications involving these transgenic animals acknowledge the services of the University of Pennsylvania Transgenic & Chimeric Mouse Facility as well as the Institute for Diabetes, Obesity, and Metabolism, the Center for Molecular Studies in Digestive and Liver Diseases, and the Abramson Cancer Center in the Materials and Methods section.
NIH has issued a statement supporting and encouraging the timely sharing and distribution of mouse resources generated using NIH funds so that other researchers can benefit form these resources http://modelorganisms.nih.gov/mouse/sharing/1.html. The term "mouse resources" includes genetically modified mice, inbred mouse strains, mutagenesis protocols, as well as DNA vectors and murine embryonic stem cells used in the production of knockout mice. Genetically modified mice are mice in which mutations have been induced by chemicals, irradiation, and transgenesis (e.g., knockouts and injection of DNA into blastocysts), in addition to mice that have had spontaneously occurring mutations.
In addition, all of the transgenic mice generated may be deposited in the Mutant Mouse Regional Resource Centers (MMRRC) http://www.mmrrc.org system. MMRRC cryopreserves embryos and distributes the frozen embryos to biomedical researchers. The MMRRC is a collaborative effort, funded by grants from the National Center for Research Resources (NCRR), NIH.
We would like to remind our users that it's their responsibility to comply with that statement.