• Purified human CD8 T-cells

    Erin Zwack/Brodsky Lab & Penn Vet Imaging Core - Murine macrophages infected with Yersinia pseudo tuberculosis. Blue indicates the cell, red is a mitochondrial stain, green is a stain for Yersinia secreted effector proteins.

  • 3D image of the inflamed meningeal membrane of a CX3CR1-GFP reporter mouse

    Claudio Giraudo - Polarization of lytic granules to the immunological synapse during the cytolytic process of human CD8 lymphocytes against cancer cells.

  • Time series of cells expressing GFP-tagged ebola viral protein VP40

    Gretchen Harms, Hunter lab - Stylized images of CD8+ T cells looking at differential localization of the transcription factor T-bet in mouse cells after infection with the parasite Toxoplasma gondii, using the Amnis ImageStream. In the cell in the first and third box, T-bet (red) does not co-localize with DAPI (blue), indicating that it is cytoplas

Autoimmunity

The Autoimmunity Program of the IFI promotes research into the derangements of immune tolerance and function that lead to autoinflammatory, autoimmune, and immunodeficient states. Examples of specific areas of interest include but are not limited to the study of: the development and loss of self-tolerance in both the innate and adaptive immune response, mechanisms of autoimmune organ damage, the relationships between autoimmunity and immunodeficiency, and therapeutic approaches to treat this group of diseases. The program supports research into basic mechansisms of immune function as well as translational studies in relevant disease states as diverse as lupus, psoriasis, multiple sclerosis, primary immunodeficiency, and pemphigus. We seek to encourage cross-divisional and cross-disciplinary collaborations in order to promote novel and far-reaching discoveries elucidating the mechanisms of autoimmune diseases.