• Purified human CD8 T-cells

    Erin Zwack/Brodsky Lab & Penn Vet Imaging Core - Murine macrophages infected with Yersinia pseudo tuberculosis. Blue indicates the cell, red is a mitochondrial stain, green is a stain for Yersinia secreted effector proteins.

  • 3D image of the inflamed meningeal membrane of a CX3CR1-GFP reporter mouse

    Claudio Giraudo - Polarization of lytic granules to the immunological synapse during the cytolytic process of human CD8 lymphocytes against cancer cells.

  • Time series of cells expressing GFP-tagged ebola viral protein VP40

    Gretchen Harms, Hunter lab - Stylized images of CD8+ T cells looking at differential localization of the transcription factor T-bet in mouse cells after infection with the parasite Toxoplasma gondii, using the Amnis ImageStream. In the cell in the first and third box, T-bet (red) does not co-localize with DAPI (blue), indicating that it is cytoplas


The focus of the Transplantation Immunology Program is alloimmunity associated with human solid organ and bone marrow transplantation therapies. Its members cover a broad range of immunological disciplines, including tolerance, inflammation, and innate, adaptive, and molecular mechanisms of alloimmunity. Specific areas of expertise include immunosuppression, ischemia-reperfusion injury, humoral and cellular mechanisms of acute rejection and chronic allograft dysfunction, cellular and molecular mechanisms of tolerance, and the impact of resident microbial populations on transplant immunity. In addition to models of transplantation, Transplantation Immunology Program members are also engaged in translational research involving human populations. As such, there is a major emphasis on team science that aligns clinicians and researchers to promote sharing of patient samples for relevant research, which in turn is used for efficient cycling of lab and human science, ideally positioning this group for strategic funding initiatives.