David Meaney, PhD and Douglas H. Smith, MD receive $9.25M grant from the Paul G. Allen Family Foundation to study cellular mechanisms of concussion and ways to improve recovery
Russell Epstein and postdoc michael Bonner provide new insights into how people navigate through the world
The study, led by Ted Satterthwaite, MD, Danielle Bassett, PhD, and Graham Baum
Why Your Brain Craves Cigarettes When You Drink
Social Ties Boost Longevity in Female Macaques, Penn-led Study Finds
Penn study weighs instant gratification vs. more prosperous future
James Eberwine Receives Scientific Innovations
Award from the Brain Research Foundation
Penn Researchers Investigate How Songbirds Teach Themselves Songs
The research was led by Vijay Balasubramanian
Peacocks, Eye Tracking, and the Brains Behind Decisions
New research from Penn Integrates Knowledge professor Michael Platt
Q&A with Amita Sehgal
New "transformative hires" in Neuroscience
BGS is delighted to announce that this year's recipient of the Jane M. Glick Graduate Student Teaching Award is Julie Blendy
Cocaine: What Happens To The Son If The Father Uses It
Penn's quest to battle Alzheimer's
Cellular Energy Flaws Studied as Contributor to Schizophrenia
Greg Bashaw Among the First to Receive NIH Funding under Novel, Multi-Year Pilot Program
More Human-like Model of Alzheimer's Better Mirrors Tangles in the Brain
Stressed-out Rats Consume More Alcohol, Revealing Related Brain Chemistry
Penn's quest to battle Alzheimer's
Penn Helps Enrich Scholarship on Concussions
A study by Maja Bucan and doctoral student Xiao Ji of Medicine used 410 mouse strains to identify 52 never-before-discovered mutations related to human diseases.
New Mouse Model Points to Drug Target Potentially Useful for Increasing Social Interaction in Autism
Penn Research Identifies Brain Network that Controls Spread of Seizures
Wade Berrettini argued for policy change and greater use of alternative treatments to address opioid abuse
Penn Biologists Reveal How Sleep Deprivation Harms Memory
Penn Alzheimer's Disease Center Headed by John Trojanowski to Receive $8.8 Million in NIH Funding
The SCAN program.
Opening up the Brain with Network Science.
Monkeys for autism research
Researchers led by Medicine's Virginia Man-Yee Lee are conducting pioneering research into causes of and potential treatments for a group of rare brain atrophy disorders.
Amita Sehgal, PhD, a professor of Neuroscience and director of the Chronobiology Program, is featured in a Stat "Science Happens" video on her lab's research on fruitflies and the mysteries of sleep.
Researchers Reagan Wetherill and Teresa Franklin of Medicine found that natural fluctuations in hormones during the menstrual cycle could help women quit smoking.
Led by Amita Sehgal of Medicine, researchers have found that a rhythm of cellular detox in flies and mammals is synchronized by a neuropeptide that also drives feeding.
A new NIH grant will allow PIK Prof Michael Platt to continue work on social functions in the brain, which could ultimately aid those with autism or schizophrenia.
Stewart Anderson of Medicine and CHOP and Vet grad student Erika Lin-Hendel have studied how tracing neuron migration offers insight into brain development defects.
Brian Litt of Medicine and Engineering co-led a study revealing that flexible and dissolvable silicon electronic devices can be used for brain monitoring.
Akiva Cohen of the Perelman School of Medicine and CHOP aims to find whether a set of neurons could be a target to prevent cognitive damage after brain injury.
Amita Sehgal, PhD, the John Herr Musser Professor of Neuroscience and director of the Chronobiology Program in the Perelman School of Medicine at the University of Pennsylvania, has been elected to the National Academy of Sciences, considered one of the highest honors accorded a U.S. scientist or engineer. Selected for "their distinguished and continuing achievements in original research," the three scientists are part of the 2016 Academy class of 84 members and 21 foreign associates from 14 countries.
Arts & Sciences postdoc Jennifer Choi Tudor and prof Ted Abel found manipulating the expression of a specific gene in mice blocked the effect of sleep deprivation on memory.
Using fruit flies, Thomas Jongens, Rachel Monyak and Sean McBride of Medicine found a possible treatment for fragile X syndrome, which causes intellectual disability.
Douglas Smith, John Trojanowski and Christina Master of Medicine and Eric Laudano of Athletics are working to better understand, prevent and treat concussions.
Michael Platt of the University of Pennsylvania has received a five-year, $2.9 million Method to Extend Research In Time, or MERIT, award from the National Institute of Mental Health to continue his work on the neural circuits that mediate complex social cognition.
A study of Parkinson's patients by Med's Christine Cooper, Alice Chen-Plotkin and colleagues identified a genetic variation linked with slower disease progression.
The annual Kids Judge science fair was covered by CBS3. Elementary school students judged hands-on activities developed by Penn neuroscience students and faculty. Graduate students Didja HilMora, Makhi Ferguson, and Carolione Keating were quoted.
Medicine's Peter Sterling called for scientists to reduce their carbon footprint while engaging in professional activities, particularly when traveling for research meetings.
The drug naltrexone was more effective at preventing drug relapse compared to the usual treatment modalities, according to Charles O'Brien of Medicine.
Vijay Balasubramanian and grad student Xue-Xin Wei of Arts & Sciences have a new theory for how the brain keeps track of locations on a mental map.
John Trojanowski and Douglas Smith of Medicine are formulating diagnostic criteria for chronic traumatic encephalopathy, a neurodegenerative disease.
Congratulations to Matthew Kayser for receiving the 2016 Sloan Fellowship Award given to early-career scientists seen as industry leaders.
Research identifying and mitigating factors that adversely affect sleep and chronobiology in space flight has earned Med's David Dinges the 2016 NSBRI Pioneer Award.
Blocking the transfer of calcium into mitochondria caused cancer cells to die, a team led by Medicine's Kevin Foskett found. The work suggests a new target for therapy.
A study by Med's Henry Kranzler found that a drug used to help alcohol-dependent individuals curb heavy drinking is most effective in those who carry a specific genotype.
Both Sides Now: Dopamine, the Brain's "Reward" Molecule, also Controls Learning to Avoid an Unpleasant Experience, Penn Animal Study Finds
The brain chemical dopamine regulates how mice learn to avoid a disagreeable encounter. "We know that dopamine reinforces 'rewarding' behaviors, but to our surprise, we have now shown that situations that animals learn to avoid are also regulated by dopamine," said senior author John Dani, PhD, chair of the department of Neuroscience. The team's findings are published this month in Cell Reports.
Some painful ligament damage can be too small to see. SEAS grad student Sijia Zhang and profs Beth Winkelstein and Danielle Bassett use network science to go deeper.
Heath Schmidt and Matthew Hayes of Nursing and Med and Nursing's Bart De Jonghe have shown that a drug used for diabetes and obesity may reduce cocaine dependence.
Kevin Foskett, Horia Vais and Karthik Mallilankaraman of Medicine have discovered the gatekeeping mechanism in mitochondria that controls the calcium ion flow.
For both biomedical student Leonardo Guercio and his mentor, Chris Pierce of Medicine, the most exciting days in the lab are when experimental results come in. (Video)
Engineering prof Vivek Shenoy, lab member Hossein Ahmadzadeh and Med's Douglas Smith have a new model that shows why the speed of impact is critical for concussions.
Engineering profs Danielle Bassett and Brian Litt, also of Med, and grad student Ankit Khambhati use network science to show how seizures spread in the brain. (Video)
PIK Professor Michael Platt discovered that the amygdala, a small structure in the brain, is associated with charitable giving and positive social behavior, not just fear.
Profs Danielle Bassett of SEAS and Brian Litt of SEAS and Med, with grad student Ankit Khambhati, use network science to show how seizures spread in the brain. (Video)
Biological basis of behavior major Jenna Hebert of Pittsburgh and international studies and econ major Debi Ogunrinde of Halifax, Nova Scotia, are new Rhodes Scholars.
Studies by Med's Douglas Smith and Robert Siman have found that even seemingly mild concussions can lead to long-term cognitive impairments and permanent brain damage.
Biology's Ted Abel, Engineering's Dennis Discher and Physics' A.T. Charlie Johnson and Mark Trodden were elected Fellows of the scientific society AAAS.
Michael Platt, a PIK professor, researches what influences decision making, including the mechanisms in the brain and the impact of the behavior of others. (Video)
Med's Maxwell Merkow and John Burke with Michael Kahana of Psychology have found that the brain's hippocampus is essential to recognition memory.
Med's C. Neill Epperson and Tracy Bale, also of Vet, are establishing an NIH-supported career-development program to promote research on sex and gender differences.
Using transparent young zebra fish as a model, Med's Michael Granato and grad student Jesse Issacman-Beck found how damaged nerves reestablish lost connections. (Video)
Using a series of brain scans, Danielle Bassett of SEAS is helping to show how maps of neural systems change and crystalize from childhood to adulthood.
Frances Jensen was elected to the National Academy of Medicine for her contributions to health research.
In recognition of her outstanding work and teaching on molecular motors, Erika Holzbaur of Medicine received the American Neurological Association's 2015 Bennett Award.
"With lab models, you can do great genetic manipulation, but you're working with mice and flies, whose social lives are not like humans," says Seth Madlon-Kay, a graduate student in Michael Platt's lab at Duke University in Durham, North Carolina, who presented the findings.
A team led by Tracy Bale of Vet and Medicine has shown at the molecular level how stress experienced by a male mouse can influence his offspring's brain development.
Using lasers to manipulate brain activity, Maria Geffen, Ryan Natan, John Briguglio and Isaac Carruthers of Med learned the mechanics of auditory understanding.
In an illustrated profile in Nautilus, Engineering's Danielle Bassett explained how changes in the way regions of the brain talk to one another impacts the learning process.
Jane M. Glick Graduate Student Teaching Award to Joshua I. Gold, PhD of the Department of Neuroscience.
Engineering's Danielle Bassett led a collaborative study that used "wiring diagrams" of the brain to show how the frontal cortex is able to control thoughts and actions.
Sensitivity to odors depends on the length of the sensory cilia and their location in the nasal cavity, according to research by Med's Rosemary Lewis and Minghong Ma.
In The Philadelphia Inquirer, Caryn Lerman of the Perelman School of Medicine is featured for developing a transcranial direct current brain stimulation test to help smokers quit.
To better understand the link between sleep loss and aggression, Medicine's Matthew Kayser and Amita Sehgal examined the behavior of sleep-deprived fruit flies.
Medicine's John Trojanowski earned the AANP Award for Meritorious Contributions to Neuropathology for his pioneering neurogenerative disease research.
Post doctoral position in Neuroimaging / Addiction / Individual Differences available at UPENN
Martha Farah of Psychology researches childhood socioeconomic status and investigates the links to mental health, cognitive ability and academic achievement.
Research led by Vet postdoc Eldin Jasarevic and prof Tracy Bale found that prenatal stress alters the mother's vaginal microbiome, affecting newborn brain development.
Michael Platt, whose research focuses on how the brain makes decisions, has been named the newest PIK Professor. He will hold appointments across three schools.
Animals from ants to mice to humans use both a mental map and mental compass to reorient themselves in familiar places, but how they determine this information from environmental cues is not well understood. In a new study, Penn researchers have shown that these systems work independently.
A study by psychology grad students Joshua Julian and Alexander Keinath and profs Isabel Muzzio and Russell Epstein examines how we get our bearings when we’re lost.
Research led by John Medaglia of Medicine has developed a new brain mapping model that could improve the effectiveness of transcranial magnetic stimulation.
Christine Swanson and Alice Chen-Plotkin of Medicine have confirmed a Parkinson's disease biomarker associated with an earlier age at onset and worse motor severity.
Medicin's Nabila Dahodwala led studies on Parkinson's that revealed a risk posed by severe diabetes and examined the caregiving differences between sexes.
Ve's Jorge Ivan Alvarez co-led a study on a protein that helps maintain the blood-brain barrier, lessening the effects of a multiple sclerosis-like disease in an animal model.
In New York Times opinion pieces, Med's Anjan Chatterjee and Martha Farah of Psychology weigh in on the use of Adderall in the office and its role in the workplace.
A new study from a team of interdisciplinary researchers at Pen's Center for Cognitive Neuroscience gives a clearer view of what drives people's changing opinions on what constitutes an attractive face. They found that people begin to see faces differently depending on the context.
A study by Kenneth Zaret of Medicine looked at how cell identity changes in the early stages of the embryo and at the implications for the cell regeneration.
Doctoral student Kait Folweiler and others from the Neuroscience Graduate Group visited a charter school to teach a hands-on neuroscience lesson.(Photos)
Frances Elizabeth Jensen, chair of the Department of Neurology in the Perelman School of Medicine, writes in Philly.com about the harmful effects that potent drugs like Molly/MDMA can have on the less-than-adult brain. She says research has shown that MDMA has highly unpredictable, toxic effects on the brain.
In a new study, Engineering's Danielle Bassett looked at the brain as a complex, dynamic network for insights into why some people learn at a faster rate than others.
David Brainard of Psychology is investigating the intricacies of the brain's reading of the color spectrum, shedding light on the process of illumination and of seeing color.
A study by Michael Granato of Medicine revealed 14 genetic mutations in zebrafish that may lead to a better understanding of human neuropsychiatric disorders.
BGS is delighted to announce that this year's recipient of the Jane M. Glick Graduate Student Teaching Award is Joshua I. Gold, Professor of Neuroscience and Neuroscience Graduate Group (NGG) Chair.
Josh will receive this award during the BGS Graduation Ceremony, scheduled for May 18, 2015 in the BRB Auditorium. Please join us in congratulating Josh on receiving this award!
Rats and humans have similar biomarkers of sleep debt, according to Amita Sehgal and Aalim Weljie of Medicine.
Fat metabolism is affected in both species.
Brian Salzberg elected by The Optical Society as 2015 Fellow
Brian Matthew Salzberg
University of Pennsylvania, USA
For development of optical methods in cell physiology and neuroscience, including the discovery of voltage sensitive dyes and calcium indicator dyes, and functional imaging using these probes.
Signs of Sleep Debt Found in the Blood
A PNAS paper on sleep and metabolism from the labs of Amita Sehgal, PhD, a professor of Neuroscience and Aalim M. Weljie, PhD, a research assistant professor of Systems Pharmacology and Translational Therapeutics, was highlighted in articles in Science News and The Scientist. They found common molecules signifying perturbed metabolism in response to sleep restriction in a comprehensive metabolic profiling of blood from both rats and humans.