Selected Key Publications:
Cheng Y, Austin SC, Rocca B, Koller BH, Coffman TM, Lawson JA & FitzGerald GA: Role of prostacyclin in the cardiovascular response to thromboxane A₂. Science 269: 539-541, 2002.

Bell-Parikh C, Ide T, Lawson JA, McNamara P, Reilly M & FitzGerald GA: Biosynthesis of 15-deoxy-Δ^12,14-PGJ₂ and the ligation of PPARγ. J Clin Invest 112; 945-955, 2003.

Egan K, Smyth E, Fries S, Rader D & FitzGerald GA: Prostacyclin confers atheroprotection on female mice. Science 306: 1954-1957, 2004.

Rudic RD, Brinster D, Cheng Y, Song W-L, Fries S, Coffman T & FitzGerald GA: COX-2 dependent prostacyclin modulates vascular remodeling. Circ. Res. 96: 1240-1247, 2005.

Price T, Lucitt MB, Wu W, Austin DJ, Pizarro A, Blair IA, FitzGerald GA & Grosser T: Protein identification using multiple tandem mass spectrometry datasets. Mol. Cell Prot. 6: 527-536, 2007.

Research Summary:
Isoeicosanoids
Isoeicosanoids are free radical catalyzed products of arachidonic Isoeicosanoids are free radical catalyzed products of arachidonic acid with potential utility as indices of oxidant stress. Methods for analyzing representatives of distinct families of isomers continue to be developed. Alterations in isoeicosanoid generation are being related to indices of oxidant injury to DNA and protein and to functional outcome in syndromes of oxidant injury in model systems and in humans.

Selected Key Publications:
Audoly LP, Rocca B, Fabre J-E, Koller BH, Thomas D, Loeb A, Coffman TM & FitzGerald GA: Cardiovascular responses to the isoprostanes, iPF₂α-III and iPE₂-III, are mediated via the thromboxane A₂ receptor in vivo. Circulation 101: 2833-2840, 2000.

Meagher EA, Barry OP, Lawson JA, Rokach J & FitzGerald GA: Effects of Vitamin E on lipid peroxidation in healthy volunteers. JAMA 285: 1178-1182, 2001.

Griendling K & FitzGerald GA: Oxidative stress and cardiovascular injury: Part 1. Basic mechanisms and in vivo monitoring of ROS. Circulation 108: 1912-1916, 2003. Part 2. Animal and human studies. Circulation 108: 2034-2040, 2003.

Song W, Lawson JA, Reilly D, Rokach J, Giasson B & FitzGerald GA: Neurofurans: Novel indices of oxidant stress derived from docosahexaenoic acid. J Biol Chem (in press), 2007.

Research Summary:
Peripheral molecular clocks
We identified a molecular clock in the vasculature and provided the first evidence for a mechanism by which a hormone could phase shift a peripheral clock. More recently, we have implicated core clock genes in the regulation of glucose homeostasis. Ongoing work seeks to define the mechanisms by which peripheral clocks regulate cardiovascular and metabolic function, the mechanisms by which they communicate with the master clock in the suprachiastmic nucleus and the mechanisms which differentiate peripheral clock function in distinct tissues.

Selected Key Publications:
McNamara P, Seo S-B, Rudic RD, Sehgal A, Chakravarti D & FitzGerald GA: Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: A humoral mechanism to reset a peripheral clock. Cell 105: 877-889, 2001.

Sato TK, Panda S, Miraglia LJ, Rudic RD, McNamara P, Sun H, FitzGerald GA, Taneja R, Kay SA & Hogenesch JB: A functional genomics strategy in the characterization of components of the mammalian circadian clock. Neuron 43: 527-537, 2004.

Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB & FitzGerald GA: BMAL1 and CLOCK, two essential components of the circadian clock are involved in glucose homeostasis. PLOS Biol 2: 1893-1899, 2004.

Rudic RD, McNamara P, Reilly D, Grosser T, Curtis AM, Price TS, Panda S, Hogenesch JB & FitzGerald GA: Bioinformatic analysis of circadian gene oscillation in mouse aorta. Circulation 112: 2716-2724, 2005.

Curtis AM, Cheng Y, Kapoor S, Reilly D, Price TS, & FitzGerald GA: Circadian variation of blood pressure and the vascular response to asynchronous stress. Proc Natl Acad Sci 104: 3450–3455, 2007.

Awards, Honors, Membership in Honorary Societies:

•	Established Investigator, American Heart Association (1985-1990)
•	Chair, Biochemistry II Study Section, NIH (1989-1990)
•	Chair, Arteriosclerosis, Thrombosis and Vascular Biology Council, AHA (2000-2001)
•	Member, Association of American Physicians (1989)
•	Fellow, American Association for the Advancement of Science (1998)
•	Member, American Society for Clinical Investigation (1986)
•	D.Sc. (Hon Causa), University of Edinburgh (2004)
•	D.Sc. (Hon Causa), University College Dublin (2004)
•	Robert Boyle Medal for Excellence in Science (Dublin: 2005)
•	William Harvey Medal for Excellence in Science (London: 2006)
•	Cameron Prize in Practical Therapeutics (Edinburgh: 2007)
•	D.Sc. (Hon Causa), University of Frankfurt (2007)

Editorial Board Memberships:

•	Circulation
•	Journal of Clinical Investigation
•	Journal of Pharmacology and Experimental Therapeutics
•	Trends in Cardiovascular Medicine

Laboratory Personnel:

	Tia Bernard Research Technician bftia@mail.med.upenn.edu		Jennifer Bruce Associate Director florence@mail.med.upenn.edu
	Yan Cheng, Ph.D. Research Assistant Professor yancheng@spirit.gcrc.upenn.edu		Susanne Fries, M.D. Research Associate fries@spirit.gcrc.upenn.edu
	Jochen Graff, M.D. Postdoctoral Fellow jograff@mail.med.upenn.edu		Tilo Grosser, M.D. Research Assistant Professor tilo@itmat.upenn.edu
	Yiqun Hui, M.D., Ph.D. Postdoctoral Fellow yiqun@mail.med.upenn.edu		Brendan Keating, Ph.D. Postdoctoral Researcher bkeating@mail.med.upenn.edu
	Takeshige Kunieda, M.D., Ph.D. Postdoctoral Fellow kunieda@mail.med.upenn.edu		Margaret Lucitt Graduate Student margaret@spirit.gcrc.upenn.edu
	Jay Mehta, M.D. Postdoctoral Fellow mehtaj@email.chop.edu		Georgios Paschos, Ph.D. Postdoctoral Fellow gpaschos@mail.med.upenn.edu
	Tom Price, Ph.D. Postdoctoral Fellow tom@spirit.gcrc.upenn.edu		Dermot Reilly, Ph.D. Postdoctoral Fellow dermot@spirit.gcrc.upenn.edu
	Emanuela Ricciotti, Ph.D. Postdoctoral Fellow emanuela@spirit.gcrc.upenn.edu		Carsten Skarke, M.D. Alexander von Humboldt - Fellow cskarke@mail.med.upenn.edu
	Emer Smyth, Ph.D. Research Assistant Professor emer@spirit.gcrc.upenn.edu		Wenliang Song, M.D. Postdoctoral Fellow wenliang@spirit.gcrc.upenn.edu
	Jane Stubbe, Ph.D. Postdoctoral Researcher jstubbe@mail.med.upenn.edu		Darshini Trivedi, Ph.D. Postdoctoral Fellow dtrivedi@mail.med.upenn.edu
	Dairong Wang, Ph.D. Research Associate dairong@spirit.gcrc.upenn.edu		Miao Wang, Ph.D. Research Associate miao@spirit.gcrc.upenn.edu
	Elizabeth Westgate Postdoctoral Researcher liz@spirit.gcrc.upenn.edu		Weili Yan Research Specialist weiliyan@mail.med.upenn.edu
	Yubing Yao Research Technician yubyao@mail.med.upenn.edu		Zhou Yu Graduate Student zhou@spirit.gcrc.upenn.edu
	Ying Yu, Ph.D. Research Associate yuying@spirit.gcrc.upenn.edu		Jueli Zhen Research Specialist zhenj@spirit.gcrc.upenn.edu

Lab Address:
Institute for Translational Medicine and Therapeutics 829 Biomedical Research Building II/III University of Pennsylvania 421 Curie Blvd. Philadelphia, PA 19104-6160 Lab Telephone: 215-898-0255 Lab Fax: 215-573-9004

Links:
http://www.itmat.upenn.edu/

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FitzGerald Laboratory Clinical Trials Unit
This Clinical Trials Unit within the Institute for Translational Medicine and Therapeutics is initially focused on protocols designed to explore cardiovascular disease and inflammation. Specifically, studies involve both mechanistic studies in volunteers and patient populations and large scale genomic analyses, particularly involving the use of the IBC (ITMAT - Broad- CARE) array, a 50K SNP array for large-scale interrogation of vascular disease cohorts. The manager assists the investigators in protocol and budget development and study design, creates consent forms and other study documents, and handles all regulatory committee submissions. Other responsibilities include supervising the research staff and managing study set-up and progress of the protocols. A dedicated and diversified team of research coordinators then implements the protocols by recruiting the subjects, ascertaining their eligibility, and scheduling and directing the study visits to the Clinical and Translational Research Center. Meticulous record keeping and data management, utilizing case report forms and electronic databases, are also key components of the entire research team to successful study completion and data analysis.

Please contact our staff for more information about our studies:

Illona Feldman, MA, CCRC, Unit Manager 972 Maloney Bldg Hospital of the University of Pennsylvania 3400 Spruce Street Philadelphia, PA 19104 215-662-4635 (office) 215-615-3455 (fax) 215-306-0332 (pager)	RESEARCH COORDINATORS 973 Maloney Bldg Hospital of the University of Pennsylvania 3400 Spruce Street Philadelphia, PA 19104 Fax: 215-573-8996
Susan Ramirez, BS 215-662-3311 (office) 215-308-6027 (pager) Lavenia Banas, R.N. 215-662-4652 (office) 215-308-0110 (pager) Kristina Alfaro, BS 215-662-4634 (office) 215-408-8557 (pager)