John Hogenesch, Ph.D.
Associate Professor of Pharmacology
Institute for Translational Medicine and 
Therapeutics
810 Biomedical Research Building II/III
University of Pennsylvania School of Medicine
421 Curie Boulevard
Philadelphia, PA 19104-6160
Telephone: 484-842-4232
Fax: 215-573-9004
Email:
Link: http://bioinf.itmat.upenn.edu/hogeneschlab/
Department of Pharmacology
John Hogenesch, Ph.D.
Education:| 1989 | B.A. (History) | University of Southern California |
| 1991 | B.S. (Biology) | University of Southern California |
| 1999 | Ph.D. (Neuroscience) | Northwestern University |
My research program covers two areas of research, the biology of circadian clocks in the mammal, and the application of functional genomics tools to understanding genome function. Key questions being approached in circadian research include the composition and mechanisms of the core oscillator, as well as the methods by which the clock dictates rhythms in physiology and behavior. Functional genomics methods are being developed and utilized in the lab that take advantage of this system, but can be more broadly applied to other areas of mammalian cell biology. By conducting research in two complementary areas of research, I hope to contribute to a better understanding of circadian clocks, as well as to the development of tools that will impact other areas of research such as translational medicine. Selected Key Publications:
Sato TK, Yamada RG, Ukai H, Baggs JE, Miraglia LJ, Kobayashi T, Welsh DK, Kay SA, Ueda HR & Hogenesch JB: Requirement for feedback repression in mammalian circadian clock function. Nat Genet 38: 312-319, 2006.
Willingham AT, Orth AP, Batalov S, Peters EC, Wen BG, Aza-Blanc P, Hogenesch JB* & Schultz PG*: A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. Science 309: 1570-1573, 2005.
Panda S, Nayak SK, Campo B, Walker JR, Hogenesch JB & Jegla TJ: Illumination of the melanopsin signaling pathway. Science 307: 600-604, 2005.
Sato TK, Panda S, Miraglia LJ, Reyes TM, Rudic RD, McNamara P, Naik KA, FitzGerald GA, Kay SA & Hogenesch JB: A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron 43: 527-37, 2004.
Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR & Hogenesch JB: A gene atlas of the mouse and human protein-encoding transcriptomes Proc Natl Acad Sci USA 101: 6062-6067, 2004.
Awards, Honors, Membership in Honorary Societies:| • | Keynote Speaker, Fall Research Symposium, The Scripps Research Institute (2001) |
| • | Member, Scientific External Planning Committee, The National Center for Biotechnology Information (NCBI) (2003-present) |
| • | Member, Scientific Advisory Panel, The National Institute of Neurological Disorders and Stroke (NINDS), The Gensat Project (2003-present) |
| • | Member, Scientific Advisory Board, Chemical Industry Institute of Toxicology (2004-2005) |
| • | Keynote Speaker, UT-ORNL Bioinformatics Summit, Falls Creek Falls, TN (2004) |
| • | Ad Hoc Reviewer, Chemical Industry Institute of Toxicology, 2006 |
| • | Ad Hoc Reviewer, Genome Canada, 2005 |
| • | Member, Scientific Advisory Board, The Ryan Licht Sang Foundation Medical Committee, 2005-present |
| • | Member, Scientific Advisory Board, Qiagen N.V., 2006-present |
| • | Member, Defense Science Study Group, Institute for Defense Analyses, 2006-present |
| • | Awardee, Keystone Innovation Zone, 2006 |
| • | Ad Hoc Reviewer, Genomics, Computational Biology and Technology Study Section (GCAT), 2006, 2007 |
| • | Ad Hoc Reviewer, Tumor Microenvironment (TME) Study Section, 2007 |
| Julie Baggs Postdoctoral Researcher  |
Jeanne Geskes Research Specialist  |
| Michael Hughes Postdoctoral Researcher  |
Anthony Olarerin Graduate Student (GCB)  |
|
Boning Li Research Associate  |
Institute for Translational Medicine and Therapeutics
835 Biomedical Research Building II/III
University of Pennsylvania School of Medicine
421 Curie Blvd.
Philadelphia, PA 19104-6160
Lab Telephone: 215-573-6313 Lab Fax: 215-573-9004