Featured Publication

Miwa T, Maldonado MA, Zhou L, Yamada K, Gilkeson GS, Eisenberg RA, Song WC. Decay-accelerating factor ameliorates systemic autoimmune disease in MRL/lpr mice via both complement-dependent and-independent mechanisms. Am J Pathol 170: 1258-1266, 2007.

[full article - pdf, 485 Kb]

Recent Publications

Barrett L, Van Bockstaele E, Sul J, Takano H, Haydon P, Eberwine J. Elk-1 associates with the mitochondrial permeability transition pore complex in neurons. Proc Natl Acad Sci 103: 5155-5160, 2006.

Barrett L, Sul J, Takano H, Van Bockstaele E, Haydon P, Eberwine J. Region-directed phototransfection reveals the functional significance of a dendritically synthesized transcription factor. Nature Methods 3: 455-460, 2006.

Bauman DR, Steckelbroeck S, Peehl DM, Penning TM. Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer. Endocrinology 147: 5806-5816, 2006.

Blair IA. Endogenous glutathione adducts. Curr Drug Metab 7: 853-872, 2006.

Brown KS, Huang Y, Lu ZY, Jian W, Blair IA, Whitehead AS. Mild folate deficiency induces a proatherosclerotic phenotype in endothelial cells. Atherosclerosis 189: 133-141, 2006

Caino MC, Oliva JL, Jiang H, Penning TM, Kazanietz MG. Benzo[a]pyrene-7,8-dihydrodiol promotes checkpoint activation and G2/M arrest in human bronchoalveolar carcinoma H358 cells. Mol Pharmacol 71: 744-750, 2007.

Christofidou-Solomidou M and Muzykantov V. Antioxidant strategies in respiratory medicine. Treat Respir Med 5: 47-78, 2006.

Colon-Gonzalez F and Kazanietz MG. C1 domains exposed: From diacylglycerol binding to protein-protein interactions. Biochim Biophys Acta 1761: 827-837, 2006.

Ding B, Dziubla T, Shuvaev V, Muro S, Muzykantov V. Advanced drug delivery systems that target vascular endothelium. Mol Interventions 6: 98-112, 2006. (Front cover)

Egan K and FitzGerald GA. Eicosanoids and the vascular endothelium. Handbook Exp Pharmacol 176 (Part 1): 189-211, 2006.

FitzGerald GA. Clinical pharmacology or translational medicine and therapeutics: Reinvent or rebrand and expand? Clin Pharmacol Ther 81: 19-20, 2007.

Fung K-M, Samara ENS, Wong C, Metwalli A, Krlin, R, Bane B, Liu CZ, Yang JT, Pitha JV, Culkin DJ, Kropp BP, Penning TM, Lin H-K. Increased expression of type 2 3α-hydroxysteroid dehydrogenase/type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma. Endocr Relat Cancer 13: 169-180, 2006.

Ganguly K, Goel M, Krasik T, Bdeir K, Diamond S, Cines D, Muzykantov V, Murciano JC. Fibrin affinity of erythrocyte-coupled tPA resists hemodynamic forces and enhances fibrinolysis in vivo. J Pharm Exp Therap 216: 1130-1136, 2006.

Gavrielides MV, Gonzalez-Guerrico AM, Riobo NA, Kazanietz MG. Androgens regulate protein kinase Cδ transcription and modulate its apoptotic function in prostate cancer cells. Cancer Research 66: 11792-11801, 2006.

Goker-Aplan O, Giasson BI, Eblan MJ, Nguyen J, Hurtig HI, Lee VM, Trojanowski JQ, Sidransky E. Glucocerebrosidase mutations are an important risk factor for Lewy body disorders. Neurology 67: 908-910, 2006.

Huber S, Song W-C, Sartini D. Decay-accelerating factor (CD55) promotes CD1d expression and Vg4+ T cell activation in coxsackievirus B3-induced myocarditis. Viral Immunol 19: 156-166, 2006.

Jensen LE, Etheredge AJ, Brown KS, Mitchell LE, Whitehead AS. Maternal genotype for the monocyte chemoattractant protein-1 A(2518)G promoter polymorphism is associated with the risk of spina bifida in offspring. Am J Med Genet (Part A) 140A: 1114-1118, 2006.

Jensen LE, Hoess K, Mitchell LE, Whitehead AS. Loss of function polymorphisms in NAT1 protect against spina bifida. Hum Genet 120: 52-57, 2006.

Jin Y and Penning TM. Multiple steps determine the overall rate of the reduction of 5α-dihydrotestosterone catalyzed by human type 3 3α-hydroxysteroid dehydrogenase: implications for the elimination of androgens. Biochemistry 45: 13054-13063, 2006.

Jin Y and Penning TM. Aldo-keto reductases and bioactivation/detoxication. Annu Rev Pharmacol Toxicol 47: 263-292, 2007.

Kim DD, Miwa T, Song WC. Retrovirus-mediated over-expression of decay-accelerating factor rescues Crry-deficient erythrocytes from acute alternative pathway complement attack. J Immunol 177: 5558-5566, 2006.

Leskow FC, Holloway BA, Wang H, Mullins MC, Kazanietz MG. The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development. Proc Natl Acad Sci 103: 5373-5378, 2006.

Maeda M, Kato S, Fukushima S, Kaneyuki U, Fujii T, Kazanietz MG, Oshima K, Shigemori M. Regulation of vascular smooth muscle proliferation and migration by β2-chimaerin, a non-protein kinase C phorbol ester receptor. Int J Mol Med 17: 559-566, 2006.

Miwa T, Zhou L, Tudoran R, Lambris JD, Madaio MP, Nangaku M, Molina H, Song WC. DAF/Crry double deficiency in mice exacerbates nephrotoxic serum-induced proteinuria despite markedly reduced systemic complement activity. Mol Immunol 44: 139-146, 2007.

Muro S, Dziubla T, Qui W, Leferovich J, Cui X, Berk E, Muzykantov VR. Endothelial targeting of high-affinity multivalent polymer nanocarriers directed to ICAM-1. J Pharm Exp Therap 317: 1161-1169, 2006.

Muro S, Matescu M, Gayewsky C, Muzykantov V, Koval M. Control of intracellular trafficking of ICAM-1 targeted nanocarriers by endothelial Na/N exchanger (NHE) proteins. Am J Physiol Lung Cell Mol Physiol 290: L809-817, 2006 (Editorial highlight).

Muro S, Schuchman E, Muzykantov VR. Lysosomal enzyme delivery by ICAM-1 targeted nanocarriers bypassing glycosylation and clathrin-mediated endocytosis. Mol Therapy 13: 135-141, 2006.

Orlando KA and Pittman RN. Rho kinase regulates phagocytosis, surface expression of GlcNAc, and Golgi fragmentation of apoptotic PC12 cells. Exp Cell Res 312: 3298-3311, 2006.

Park J-H, Troxel AB, Harvey RG, Penning TM. Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species. Chem Res Toxicol 19: 719-728, 2006.

Peritz T, Zeng F, Kannanayhakal T, Kilk K, Eiriksdottir E, Langel U, Eberwine J. Immunoprecipitation of mRNA-protein complexes. Nature Protocols 1: 577-580, 2006.

Perkowski S, Scherpereel A, Murciano JC, Arguiri E, Solomides CC, Albelda SM, Muzykantov V, Christofidou-Solomidou M. Dissociation between alveolar transmigration of neutrophils and lung injury in hyperoxia. American Journal of Physiology - Lung Cellular & Molecular Physiology 291: L1050-L1058, 2006.

Pollack M, Yang IY, Kim HY, Blair IA, Moriya M. Translesion DNA synthesis across the heptanone-etheno-2'-deoxycytidine adduct in cells. Chem Res Toxicol 19: 1074-1079, 2006. [Front cover]

Ruan Q, Kim H-Y, Jiang H, Penning TM, Harvey RG, Blair IA. Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 20: 1369-1380, 2006.

Shen YM, Troxel AB, Vedantam S, Penning TM, Field J. Comparison of p53 mutations induced by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: role of reactive oxygen and biological selection. Chem Res Toxicol 19: 1441-1150, 2006.

Song W-C. Complement regulatory proteins and autoimmunity (review). Autoimmunity 39: 403-410, 2006.

Stanislawska-Sachadyn A, Jensen LE, Kealey C, Woodside JV, Young IS, Scott JM, Murray L, Boreham CA, McNulty H, Strain JJ. Whitehead AS. Association between the NAT1 1095C > A polymorphism and homocysteine concentration. Am J Med Genet (Part A) 140: 2374-2377, 2006.

Von Feldt JM, Scalzi LV, Cucchiara AJ, Morthala S, Kealey C, Flagg SD, Genin A, Van Dyke AL, Nackos E, Chander A, Gehrie E, Cron RQ, Whitehead AS. Homocysteine levels and disease duration independently correlate with coronary artery calcification in systemic lupus erythematosus patients. Arthritis and Rheumatism 54: 2220-2227, 2006.

Wang H and Kazanietz MG. The lipid second messenger diacylglycerol as a negative regulator of Rac signalling. Biochem Soc Trans 34: 855-857, 2006.

Wang H, Yang C, Leskow FC, Sun J, Canagarajah B, Hurley JH, Kazanietz MG. Phospholipase Cγ/diacylglycerol-dependent activation of β2-chimaerin restricts EGF-induced Rac signaling. EMBO J 25: 2062-2074, 2006.

Wang M, Zukas AM, Hui Y, Ricciotti E, Pure E, FitzGerald GA. Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis. Proc Natl Acad Sci 103: 14507-14512, 2006.

Yee DJ, Balsanek V, Bauman DR, Penning TM, Sames D. Fluorogenic metabolic probes for direct activity readout of redox enzymes: Selective measurement of human AKR1C2 in living cells. Proc Natl Acad Sci USA 103: 13304-13309, 2006.

Yu Y, Fan J, Chen XS, Wang D, Klein-Szanto AJ, Campbell RL, FitzGerald GA, Funk CD. Genetic model of selective COX2 inhibition reveals novel heterodimer signaling. Nat Med 12: 699-704, 2006.

Zaitsev S, Danielyan K, Murciano JC, Krasik T, Taylor RP, Pincus S, Jones SM, Cines DB, Muzykantov VR. CR1-directed targeting of tPA to circulating erythrocytes for prophylactic fibrinolysis. Blood 108: 1895-1902, 2006 (Editorial highlight).

Zeng F, Peritz T, Kannanayhakal T, Kilk K, Eiriksdottir E, Langel U, Eberwine J. A protocol for PAIR: PNA assisted identification of RNA binding proteins in living cells. Nature Protocols 1: 920-927, 2006.

Zheng N, Pang S, Oe T, Felix CA, Wehrli S, Blair IA. Characterization of an etoposide-glutathione conjugate derived from metabolic activation by human cytochrome p450. Curr Drug Metab 7: 897-911, 2006.

Zhong X and Pittman RN. Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. Hum Mol Genet 15: 2409-2420, 2006.

Zhou W, Hashimoto K, Goleniewska K, O'Neal JF, Ji S, Blackwell TS, FitzGerald GA, Egan KM, Geraci MW, Peebles RS Jr. Prostaglandin I2 analogs inhibit pro-inflammatory cytokine production and T cell stimulatory function of dendritic cells. J Immunol 178: 702-710.

Zhu P, Lee SH, Wehrli S, Blair IA. Characterization of a lipid hydroperoxide-derived RNA adduct in rat intestinal epithelial cells. Chem Res Toxicol 19: 809-817, 2006.

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Research Areas

A representation of fibrinolysis at a clot by tPA-coupled red blood cells
(see Murciano et al. p 891). Artwork by Erin Boyle. Image of blood clot (c)

Prophylactic fibrinolysis through selective dissolution of nascent clots by
tPA-carrying erythrocytes.

Juan-Carlos Murciano, Sandra Mednilla, Donald Eslin, Elena Atochina,
Douglas B. Cines & Vladimir R. Muztkantov.