Synovial Biopsy, Synovium, Synovial Fluid & Arthrocentesis

Rheumatoid Arthritis - RA (Synovium) Photo/Slide Viewer


References Related to RA (Synovium)


Muirden KD and Peace G. Light and electrom microscope studies in carragheenin, adjuvant, and tuberculin-induced arthritis. Annals of the Rheumatic Diseases 28:392-401, 1969.

Newton C, Halliwell R, Allen HL, Schumacher, HR: Clinicopathologic conference. Rheumatoid-like polyarthritis in a dog. J Am Vet Med Assoc 165:459-464, 1974.

Reginato AJ, Martinez VA , Schumacher HR, Torres J: Giant cell tumor associated with rheumatoid arthritis. Ann Rheum Dis 33:333-341, 1974.

Pascual E, Steinberg M, Schumacher HR: Restoration of the hip joint space in long-standing rheumatoid arthritis following contralateral cup arthroplasty. Clin Orthop 111:121-123, 1975.

Newton CC, Lipowitz AJ, Halliwell RE, Allen HL, Biery DN, Schumacher HR: Rheumatoid arthritis in dogs. J Am Vet Med Assoc 168:113-121, 1976.

Wynne-Roberts CR, Anderson CH, Turano AM and Baron M. Light- and electron-microscopic findings of juvenile rheumatoid arthritis synovium: comparison with normal juvenile synovium. Seminars in Arthritis & Rheumatism 7:287-302, 1978.

Schumacher HR, Newton C, Halliwell REW: Synovial pathologic changes in spontaneous canine rheumatoid-like arthritis. Arthritis Rheum 23:412-423, 1980.

Blake DR, Gallagher PJ, Potter AR et al. The effect of synovial iron on the progression of rheumatoid disease. Arthritis & Rheumatism 27:495-501, 1984.

Yocum DE, Lafyatis R, Remmers EF, Schumacher HR, Wilder RL: Hyperplastic synoviocytes from rats with streptoccocal cell wall-induced arthritis exhibit a transformed phenotype that is thymic-dependent and retinoid inhibitable. Am J Pathol 132:38-48, 1988.

Rosenthal NS and Farhi DC. Bone marrow findings in connective tissue disease. Am J of Clinical Pathology 92:650-4, 1989.

Tak-Diamant Z, Hooning van Duyvenbode FJJ, Eulderink F, and Janssen M. Intra-articular rheumatoid nodules and triggering of the knee joint. Annals of the Rheumatic Diseases 51:533-535, 1992.

Pras E, Schumacher HR, Kastner DL, Wilder RL: Lack of evidence of mycobacteria in synovial tissue from patients with rheumatoid arthritis. Arth Rheum 39: 2080-2081, 1996.

Kotake S, Schumacher HR, Yarboro CH, Arayssi TK, Pando JA, Kanik KS, Gourley MF, Klippel JH, Wilder RL: In vivo gene expression of type 1 and type 2 cytokines in synovial tissues from patients in early stages of rheumatoid, reactive, and undifferentiated arthritis. Proc Assoc of Am Phys 109:286-302,1997.

Littman BH, Schumacher HR, Boyle DL, Weisman MH, Firestein GS: Effect of tenidap on metalloproteinase gene expression in rheumatoid arthritis: A synovial biopsy study. J Clin Rheumatol 3:194-202, 1997.

Edinger JW, Bonneville M, Scotet E, Houssaint E, Schumacher HR, Posnett DN: EBV gene expression not altered in rheumatoid synovia despite the presence of EBV antigen-specific T cell clones. J Immunol 162:3694-3701, 1999.

McGonagle D, Gibbon W, O'Connor P, et al. A preliminary study of ultrasound aspiration of bone erosion in early rheumatoid arthritis. Rheumatology 38:329-331, 1999.

Goldbach-Mansky R, Lee J, McCoy A, et al. Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res 2:236-243, 2000.

Goldbach-Mansky R, Lee J, Hoxworth JM et al. Active synovial matrix matalloproteinase-2 is associated with radiographic erosions in patients with early synovitis. Arthritis Res 2:145-153, 2000.

Benedikt O, Peters R, Dann P, et al Magnetic resonance imaging and miniarthroscopy of metacarpophalangeal joints. Arthritis & Rheumatism, 44:2492-2502, 2001.

Schumacher HR, Pessler F, Chen LX. Diagnosing early rheumatoid arthritis (RA). What are the problems and opportunities? Clin Exp Rheumatol 21 (Suppl.31):S15-S19, 2003.

Zhang H, Guangping G, Clayburne G & Schumacher HR: Elimination of rheumatoid synovium in situ using a Fas Ligand ‘gene scalpel.’ Arth Res & Ther 7:R1235-R1243, 2005.

Krenn V, Morawietz L, Burmester G-R, et al. Synovitis score: discrimination between chronic low-grade and high-grade synovitis. Histopathology 49:358-364, 2006.

Baeten D, Houbiers J, Kruithof E, et al. Synovial inflammation does not change in the absence of effective treatment: implications for the use of synovial histopathology as biomarker in early phase clinical trials in rheumatoid arthritis. Ann Rheum Dis 65:990-997, 2006.

Lee Y-A, Kim JY, Hong S-J et al. Synovial proliferation differentially affects hypoxia in the joint cavities of rheumatoid arthritis and osteoarthritis patients. Clin Rheumatol 26:2023-2029, 2007.

Rooney T, Bresnihan B, Andersson U, et al. Microscopic measurement of inflammation in synovial tissue: inter-observer agreement for manual quantitative, semiquantitative and computerised digital image analysis. Ann Rheum Dis 66:1656-1660, 2007.

van Oosterhout M, Bajema I, Levarht EWN, et al. Differences in synovial tissue infiltrates between anti-cyclic citrullinated peptide-positive rheumatoid arthritis and anti-cyclic citrullinated peptide-negative rheumatoid arthritis. Arthritis & Rheumatism 58:53-60, 2008.

Nandakumar KS, Bajtner E, Hill L, et al. Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation. Arthritis & Rheumatism 58:184-196, 2008.

Edwards JCW and Leandro MJ. Lymphoid follicles in joints: what do they mean? Editorial, Arthritis & Rheumatism 58:1563-1565, 2008.

Thurlings RM, Wijbrandts CA, Mebius RE et al. Synovial lymphoid neogenesis does not define a specific clinical rheumatoid arthritis phenotype. Arthritis & Rheumatism 58:1582-1589, 2008.

van Maanen MA, Stoof SP, van der Zanden EP, de Jonge WJ, Janssen RA, Fischer DF, Vandeghinste N, Brys, R, Vervoordeldonk MJ and Tak PP. The alpha7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients. Arthritis & Rheumatism 60(5):1272-1281, 2009.

Pitzalis C, Kelly S, and Humby F. New learnings on the pathophysiology of RA from synovial biopsies., 25:3, May 2013, 334-344, publisher: Lippincott Williams & Wilkins.

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