Synovial Biopsy, Synovium, Synovial Fluid & Arthrocentesis

About H. Ralph Schumacher, Jr., M.D.

H. Ralph Schumacher, Jr., MD is Professor of Medicine at the University of Pennsylvania School of Medicine, Director of the Arthritis-Immunology Center at the Philadelphia VA, and former Chief of Rheumatology at the VA Medical Center, Philadelphia. He has been studying all aspects of the synovium, synovial fluid and crystal deposition disease for 40 years. He is preparing this resource to make his educational material widely accessible and to encourage dialogues on these subjects. He is author of scientific papers, books, and many reviews and editorials. His work has addressed clinical aspects, light and electron microscopy, immunohistochemistry, molecular biology and physiology of the joint.

Dr. Schumacher's CV is available online: HRS CV

Colchicum autumnalis, Fall 1985 in the Schumacher garden.

H. Ralph Schumacher in an ancient medical theatre in Padova, Italy.

H. Ralph Schumacher playing basketball in Taipei during sabbatical, 1981.

Spring 2008, Schumacher garden, view up past jungle gym

Schumacher garden patio, Spring 2008.

 

Dr. Schumacher and gout sufferer "Ben Franklin"

 

Some Life Lessons that I See Suggested from My Electron Micrographs:

REACH OUT

This synovial macrophage is reaching out with dramatic processes to enfold a lymphocyte. EM, 7500X..

 

STICK TOGETHER

Platelets sticking together are occluding synovial vessel. Multilaminated basement membrane seems to suggest a wrapping. EM, 5000X.

 

COOPERATE

Activated lymphocytes and adjacent plasma cell with rough endoplasmic reticulum cooperate in stimulation and antibody production. EM, 25,000X..

 

DEPART FROM THE ROUTINE

Very unusual pericyte processes depart from the routine and extend through venule endothelial gaps, EM, 10,000X..

 

HUG

Multiple "arms" from this synovial cell enfold a process from another cell. EM, 30,000 X.

 

TAKE ACTION

This intraluminal leukocyte is degranulating in a vessel wall injured by dense deposits of presumed immune complexes, EM, 6,000X.

 

BE FLEXIBLE

The large cell with profuse polyribosomes is a lymphoblast transformed from a small lymphocyte. EM, 20,000X.

 

TRY TO HEAL

A vessel has been destroyed and is beginning to be replaced by a fibrous scar. EM, 6,000 X.

 

 

BE A BIT MYSTERIOUS AND NOT AFRAID TO BE PUZZLED

What is going on in this cell? EM, 28,000 X.

 

BE PRODUCTIVE

This mast cell produces histamine and other vasoactive substances to act on the adjacent vessel. EM, 10,000 X.

 

Click Here to See the Opening Lecture at ACR 2009

Click Here to See Article in VA Newsletter, Summer 2011, featuring Dr. Schumacher

Click Here to See Article in The Rheumatologist, Jan. 2010 featuring Dr. Schumacher

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