Publications

Effects of current smoking severity on brain gray matter volume in opioid use disorder - a voxel-based morphometry study
Shi Z, Li X, Byanyima JI, O'Brien CP, Childress AR, Lynch KG, Loughead J, Wiers CE, Langleben DD
American Journal of Drug and Alcohol Abuse 2023, 180-189

Metabolic profiles associated with opioid use and opioid use disorder: A narrative review of the literature
Byanyima JI, Li X, Vessel SA, Kranzler HR, Shi Z, Wiers CE
Current Addiction Reports 2023

Changes in synaptic markers after administration of ketamine or psychedelics: a systematic scoping review
Zhornitsky S, Oliva HNP, Jayne LA, Allsop ASA, Kaye AP, Potenza MN, Angarita GA
Front Psychiatry 2023

Identifying genetic loci and phenomic associations of substance use traits: A multi-trait analysis of GWAS (MTAG) study
Xu H, Toikumo S, Crist RC, Glogowska K, Jinwala Z, Deak JD, Justice AC, Gelernter J, Johnson EC, Kranzler HR, Kember RL
Addiction 2023, 1-11

Does polygenic risk for substance-related traits predict ages of onset and progression of symptoms?
Kranzler HR, Feinn R, Xu H, Ho BL, Saini D, Nicastro OR, Jacoby A, Toikumo S, Gelernter J, Hartwell EE, Kember RL
Addiction 2023 118, 1675-1686

The genetic architecture of pain intensity in a sample of 598,339 U.S. veterans
Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell E, Venegas MP, Sullivan KA, Xu K, Jacobson DA, Gelernter J, Rentsch CT; Million Veteran Program; Stahl E, Cheatle M, Zhou H, Waxman SG, Justice AC, Kember RL, Kranzler HR
medRxiv 2023, 1-38

Molecular Imaging of Pulmonary Inflammation: Claiming That Vaping Is More Harmful Than Smoking Is Unsupported
Wetherill RR, Dubroff J
Journal of Nuclear Medicine 2023 64, 994-995

In vivo imaging and kinetic modeling of novel glycogen synthase kinase-3 radiotracers [11C]OCM-44 and [¹⁸F]OCM-50 in non-human primates
Smart K, Zheng MQ, Holden D, Felchner Z, Zhang L, Han Y, Ropchan J, Carson RE, Vasdev N, Huang Y
Pharmaceuticals 2023 16, 1-12

Molecular Imaging of Pulmonary Inflammation in Electronic and Combustible Cigarette Users: A Pilot Study
Reagan R. Wetherill, Robert K. Doot, Anthony J. Young, Hsiaoju Lee, Erin K. Schubert, Corinde E. Wiers, Frank T. Leone, Robert H. Mach, Henry R. Kranzler1, Jacob G. Dubroff Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Comprehensive Smoking Treatment Program, Penn Lung Center, Philadelphia, PA, USA Crescenz VAMC, Philadelphia, PA, USA.
Journal of Nuclear Medicine 2023, 1-27

[¹⁸F]NOS PET Brain Imaging Suggests Elevated Neuroinflammation in Idiopathic Parkinson's Disease Doot RK, Young AJ, Nasrallah IM, Wetherill RR, Siderowf A, Mach RH, Dubroff JG
Cells 2022 11, 1-10

Unique and joint associations of polygenic risk for major depression and opioid use disorder with endogenous opioid system function
Love T, Shabalin AA, Kember RL, Docherty AR, Zhou H, Koppelmans V, Gelernter J, Baker AK, Hartwell E, Dubroff J, Zubieta JK, Kranzler HR
Neuropsychopharmacology 2022 47, 1784-1790

Integrating human brain proteomic data with genome-wide association study findings identifies novel brain proteins in substance use traits
Toikumo S, Xu H, Gelernter J, Kember RL, Kranzler HR
Neuropsychopharmacology 2022 47, 2292-2299

Positron Emission Tomography of Neuroimmune Responses in Humans: Insights and Intricacies
Nakul R. Raval, PhD, Reagan R. Wetherill, PhD, Corinde E. Wiers, PhD, Jacob G. Dubroff, MD, PhD, and Ansel T. Hillmer, PhD
Seminars in Nuclear Medicine 2022 53, 213-229

Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample
Rachel L. Kember, Emily E. Hartwell, Heng Xu, James Rotenberg, Laura Almasy, Hang Zhou, Joel Gelernter, and Henry R. Kranzler
Biological Psychiatry 2022, 536-545

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction
Rachel L. Kember , Rachel Vickers-Smith, Heng Xu, Sylvanus Toikumo, Maria Niarchou , Hang Zhou , Emily E. Hartwell , Richard C. Crist, Christopher T. Rentsch , Million Veteran Program*, Lea K. Davis, Amy C. Justice , Sandra Sanchez-Roige , Kyle M. Kampman, Joel Gelernter , and Henry R. Kranzler
Nature Neuroscience 2022 25, 1279-1287

Analysis of genetic and clinical factors associated with buprenorphine response
Richard C. Crist, Rachel Vickers-Smith, Rachel L. Kember, Christopher T. Rentsch, Heng Xu, E. Jennifer Edelman, Emily E. Hartwell, Kyle M. Kampman, Henry R. Kranzler
Drug and Alcohol Dependence 2021 227, 1-6

Multivariate pattern analysis links drug use severity to distributed cortical hypoactivity during emotional inhibitory control in opioid use disorder
Shi Z, Langleben D, O’Brien CP, Childress AR, Wiers CE
Neuroimage Clinical 2021 32, 1-8