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Horace M. DeLisser, MD
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Professor of Medicine (Pulmonary, Allergy and Critical Care) at the Hospital of the University of Pennsylvania
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Department: Medicine
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Contact information
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Room 644
48 6th Floor, South Pavilion, Perelman Center for Advanced Medicine
3e 3400 Civic Center Blvd
Philadelphia, PA 19104-5162
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48 6th Floor, South Pavilion, Perelman Center for Advanced Medicine
3e 3400 Civic Center Blvd
Philadelphia, PA 19104-5162
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Office: (215) 898-4409
34 Fax: (215) 898-0833
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34 Fax: (215) 898-0833
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Education:
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2b Temple University , 1981.
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33 University of Pennsylvania, 1985.
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Permanent link21 7 BA c
2b Temple University , 1981.
21 9 M.D. c
33 University of Pennsylvania, 1985.
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33 [1] Endothelial Cell Adhesion and Motility
18 [2] Angiogenesis
1e [3] Tumor Metastasis
22 [4] Pulmonary Hypertension
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26 Description of Research
1e6 PECAM-1 AND ANGIOGENESIS: The formation of blood vessels involves the migration of endothelial cells from preexisting vessels and their subsequent assembly into new vascular channels. PECAM-1 is an endothelial-expressed molecule that appears to play a role in angiogenesis by promoting the efficiency of endothelial cell migration. Current studies in my laboratory investigate the intracellular signaling cascades, triggered by PECAM-1, that promote endothelial cell motility.
1d5 PECAM-1 AND TUMOR METASTASIS TO THE LUNG: In an emerging area for our group, recent collaborative efforts by our laboratory have demonstrated that antagonism of PECAM-1 function or loss of its expression on endothelial cells inhibits the development of experimental lung metastases. It appears that the mechanism of this inhibition does not involve an impairment of angiogenesis, but other potential processes that are now the subject of active investigation.
28d PULMONARY HYPERTENSION: Since 2011, I have served as the Director of Cell Center Core for the Pulmonary Hypertension Breakthrough Initiative located at the University of Pennsylvania. Using techniques we have developed that enable the site-specific isolation of endothelial, smooth muscle and advential cells from the main and types I, II, and III arterial segments, our core has been successfully responsible for isolating, banking and distributing to investigators across the country lung vascular cells. In addition, we have been actively engaged in characterizing the site-specific functional and molecular differences between these cells.
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1e Lab personnel:
35 Valsamma Abraham, PhD– Senior Investigator
30 Rahul Kupar, B.S. – Research Specialist
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Description of Research Expertise
2b Research Interests33 [1] Endothelial Cell Adhesion and Motility
18 [2] Angiogenesis
1e [3] Tumor Metastasis
22 [4] Pulmonary Hypertension
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26 Description of Research
1e6 PECAM-1 AND ANGIOGENESIS: The formation of blood vessels involves the migration of endothelial cells from preexisting vessels and their subsequent assembly into new vascular channels. PECAM-1 is an endothelial-expressed molecule that appears to play a role in angiogenesis by promoting the efficiency of endothelial cell migration. Current studies in my laboratory investigate the intracellular signaling cascades, triggered by PECAM-1, that promote endothelial cell motility.
1d5 PECAM-1 AND TUMOR METASTASIS TO THE LUNG: In an emerging area for our group, recent collaborative efforts by our laboratory have demonstrated that antagonism of PECAM-1 function or loss of its expression on endothelial cells inhibits the development of experimental lung metastases. It appears that the mechanism of this inhibition does not involve an impairment of angiogenesis, but other potential processes that are now the subject of active investigation.
28d PULMONARY HYPERTENSION: Since 2011, I have served as the Director of Cell Center Core for the Pulmonary Hypertension Breakthrough Initiative located at the University of Pennsylvania. Using techniques we have developed that enable the site-specific isolation of endothelial, smooth muscle and advential cells from the main and types I, II, and III arterial segments, our core has been successfully responsible for isolating, banking and distributing to investigators across the country lung vascular cells. In addition, we have been actively engaged in characterizing the site-specific functional and molecular differences between these cells.
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1e Lab personnel:
35 Valsamma Abraham, PhD– Senior Investigator
30 Rahul Kupar, B.S. – Research Specialist
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