Hongzhe Li (Lee), Ph.D.
Perelman Professor in Biostatistics, Epidemiology, and Informatics
Department: Biostatistics and Epidemiology
Graduate Group Affiliations
Contact information
Department of Biostatistics and Epidemiology
University of Pennsylvania Perelman School of Medicine
215 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
University of Pennsylvania Perelman School of Medicine
215 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
Office: 215-573-5038
Fax: 215-573 1050
Fax: 215-573 1050
Email:
hongzhe@upenn.edu
hongzhe@upenn.edu
Education:
B.S. (Mathematics/Information)
Peking University, 1989.
Ph.D. (Statistics)
University of Washington, 1995.
Permanent linkB.S. (Mathematics/Information)
Peking University, 1989.
Ph.D. (Statistics)
University of Washington, 1995.
Description of Research Expertise
My methods reserach was mostly motivated by problems in genetics and genoimics. I have worked on a variety problems in statistical genetics and genomics, including methods for family-based genetic linkage and association analysis, methods for admixture mapping, methods for genome-wide association analysis, methods for analysis of microarray time course gene expression data, high dimensional regression analysis for genomic data, methods for copy number variation analysis and methods for analysis of next generation sequence data. I have published both statistical methodological research in top statistics/biostatistics journals (JASA, AOS, AOAS, Biometrika, Biometrics, Biostatistics etc ) and in top genetics journals (AJHG, Plos Genetics, etc) and collaborative research in top scientific journals (Science, NEJM, Nature, Nature Genetics, PNAS, Developmental Cell etc).Selected Publications
Fengling Hu 1, Jiayi Tong 2 3, Margaret Gardner 4; Lifespan Brain Chart Consortium; Andrew A Chen 5, Richard A I Bethlehem 6, Jakob Seidlitz 4 7 8 9, Hongzhe Li 10, Aaron Alexander-Bloch 4 7 8 9, Yong Chen 2, Russell T Shinohara : dGAMLSS: an exact, distributed algorithm to fit Generalized Additive Models for Location, Scale, and Shape for privacy-preserving population reference charts. Bioinformatics 42(1): btaf625, Jan 2026.Whiteside SA, McGinniss JE, Deek RA, Merenstein C, Britton N, Simon-Soro A, Oyster M, Kalman L, Brown MC, Graham-Wooten J, McDyer JF, Shah P, D'Alessio F, Cantu E, Clausen ES, Li H, Diamond JM, Bushman FD, Christie JD, Collman RG: Lung transplant for CF: Low lung bacterial burden and immune mediators in year one associate with CLAD development. Journal of Cystic Fibrosis 25(1): 52-62, Jan 2026.
Hu X, Huang J, Yuan J, Sun Y, Wang Y, Hu Z, Jiang J, Wang Z, Wang B, Long M, Maxwell KN, Fan Y, Tanyi JL, Montone KT, Li H, Kim SH, Nathanson KL, Rebbeck TR, Domchek SM, Vonderheide RH, Zhang L: Immune gene diversity and STING1 variants in shaping cancer immunity across different genetic ancestry populations. Cell reports 45(2): 116882, Jan 2026.
White BE, Ren Y, Li H, DeMarshall M, Yang Z, Falk GW : Indefinite for dysplasia in Barrett's esophagus carries substantial risk for prevalent and incident neoplasia: updated outcomes and long-term follow-up. Gastrointestinal Endoscopy 103(1): 73-83, Jan 2026.
7. Mayer LS, Jakob Arnold, Nadine Reuter, Ajinkya Pattekar, Takuya Ohtani, Mariana M. Ribeiro, Rebecca Siwicki, Kerstin Bruder, David Obwegs, Elin Stahl, Julia Kolter, Zohreh Mansoori Moghadam, Ahmed Alaswad, Zhibek Zhumalidova, Guang Li, Xinjuan Liu, Yang Li, Amit Singh, Jose Villacorta Hidalgo, Maria D. Paraskevopoulou, Vijay Yajnik, Julius Juarez, Yue Ren, Li H, E. John Wherry, James D. Lewis, Gary D. Wu, Meenakshi Bewtra, Vesselin T. Tomov, Robert Thimme, Bertram Bengsch, Peter Hasselblatt, Simone Picelli, Maike Hofmann, Sagar : Single-cell Profiling Reveals Diverse γδ T Cell Subsets in Ulcerative Colitis. Science Immunology 11: eadx8474, 2026.
9. Damani R, Shubha Vasisht, Valerie Luks, Gracia Maria Vargas, Charlene Compher, Paul M Titchenell, Gregory Tasian, Li H, Gary D Wu, Walter R Witschey, Gershuni VM: Sex-based differences in imaging-derived body composition and their association with clinical malnutrition in abdominal surgery patients. Nutrients 2026.
Li C, Richards SM, Quinn G, Abedini A, Zhu M, Verma T, Li F, Pitts R, Barros V, Qiu X, Shin T, Loureiro JJ, Finkel N, Surapaneni A, Coresh J, Grams ME, Karihaloo A, Li H, Verma A, Ritchie M, Rader DJ, Penn Medicine BioBank, Dietrich WF, Jennings LL, Susztak K: Plasma Proteomics Risk in APOL1 High-Risk with Preserved Kidney Function. Nature Medicine 2026.
Tanes C, Li Y, Falk GW, Ginsberg GG, Wang KK, Iyer PG, Lightdale CJ, Del Portillo A, Lagana SM, Wang TC, Rustgi AK, Quante M, Jin Z, Wu GD, Friedman ES, Bittinger K, Li H, Abrams JA: Increased reflux secondary bile acids are associated with changes to the microbiome and transcriptome in Barrett's esophagus. Gut Microbes 17(1): 2545420, Dec 2025.
Ren Y, Segal MR, Shafi T, Pico AR, Shin MG, Traglia M, Li H, Rosas SE, Choles HR, Rao PS, Bhat Z, Anderson AH, Chen J, He J, Sozio S, Jaar B, Estrella MM, Chen W, Chertow GM, Parekh RS, Ganz P, Dubin RF; CRIC Study Investigators: Risk factors for mortality in patients with kidney failure on hemodialysis identified by proteomic analysis of CRIC and PACE studies. Nature communications 16(1): 11689, Nov 2025.
Kang H, Goudra B, Devaro D, Schanzer N, Bogardus C, Ren Y, Li H, Lewis JD, Panganamamula K: Relationship Between Timing of Hemodialysis and Procedure-Related Complications Following Endoscopy in Patients with End-Stage Renal Disease. Digestive diseases and sciences 70(11): 3863-3872, Nov 2025.