Jay Fitzgerald Dorsey, M.D., Ph.D.
Associate Professor of Radiation Oncology
Department: Radiation Oncology
Graduate Group Affiliations
Contact information
Department of Radiation Oncology
Perelman Center for Advanced Medicine
Bldg 421 SCTR 8-135
3400 Civic Center Blvd
Philadelphia, PA 19104
Perelman Center for Advanced Medicine
Bldg 421 SCTR 8-135
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: (215) 662-2428
Fax: (215) 349-5445
Fax: (215) 349-5445
Publications
Links
Search PubMed for articles
Dorsey Lab Website
Department of Radiation Oncology, University of Pennsylvania
Search PubMed for articles
Dorsey Lab Website
Department of Radiation Oncology, University of Pennsylvania
Education:
BSChE (Chemical Engineering)
University of Florida, 1995.
MSChE (Chemical Engineering)
University of South Florida, 1997.
M.D.
University of South Florida College of Medicine, 2003.
Ph.D.
University of South Florida (H. Lee Moffitt Cancer Research Institute), 2003.
Permanent linkBSChE (Chemical Engineering)
University of Florida, 1995.
MSChE (Chemical Engineering)
University of South Florida, 1997.
M.D.
University of South Florida College of Medicine, 2003.
Ph.D.
University of South Florida (H. Lee Moffitt Cancer Research Institute), 2003.
Description of Research Expertise
Jay Dorsey, MD, PhD has been continuously funded by the NIH for the past decade. He has expertise in genomics, precision medicine, circulating tumor material/liquid biopsy, molecular diagnostics, cancer biomarkers, nanoparticle therapeutics, preclinical tumor models, and clinical trials. His lab focuses on translational-facing research that explores areas of brain tumor biology, biomarkers of resistance/sensitivity to radiation and chemotherapies and identification of predictive/prognostic single-cell biomarkers of solid tumors, including GBM, lung and melanoma. He is Co-Leader of the Abramson Cancer Center's RadOnc Translational Center of Excellence.Dr. Dorsey also serves as a standing member of the K99/R00 transition to independence NIH study section and is the PI and Director of (NIH R25-funded undergraduate research pipeline program) SUPERS@PENN program which seeks to introduce the next generation of biomedical scientists to undergraduate research in oncology/medical physics/bioengineering/radiology/radiation biology.
He has published in journals such as Cancer Research, Cell, Nature Communications, Nature Cancer, ACS Nano, Int J Radiat Oncol Biol Phys., and Molecular Cancer Research.
His work has been funded by ASCO, RSNA, Burroughs Wellcome Fund, and the National Institutes of Health.
Selected Publications
Messing I, Linkowski L, Riina MD, Berger M, Baron J, Wang X, Kallan M, Hubbeling HG, Lustig RA, Dorsey JF, Kurtz G, Nagda S, Lukens JN, Flowers A, Lee JYK, Amankulor NM, Jackson C, Mohan S, Amaravadi RK, Schuchter LM, Huang AC, Mitchell TC, Alonso-Basanta M, Lebow ES : Outcomes after SRS and ipilimumab plus nivolumab for melanoma brain metastases following prior immune checkpoint inhibitor or targeted therapy Oncologist 31(4), Mar 2026.Ni H, Reitman ZJ, Zou W, Akhtar MN, Paul R, Huang M, Zhang D, Zheng H, Zhang R, Ma R, Ngo G, Zhang L, Diffenderfer ES, Motlagh SAO, Kim MM, Minn AJ, Dorsey JF, Foster JB, Metz J, Koumenis C, Kirsch DG, Gong Y, Fan Y : FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy Nat Cancer 6(3), Mar 2025.
Dastgheyb SS, Dreyfuss AD, LaRiviere MJ, Mohiuddin JJ, Baumann BC, Shabason J, Lustig RA, Dorsey JF, Lin A, Grady SM, O'Malley BW, Lee JYK, Newman JG, Schuster JM, Alonso-Basanta M.: A Prospective Phase I/II Clinical Trial of High-Dose Proton Therapy for Chordomas and Chondrosarcomas. Adv Radiat Oncol 9: 101456, Feb 2024.
Zhang D, Cleveland AH, Krimitza E, Han K, Yi C, Stout AL, Zou W, Dorsey JF, Gong Y, Fan Y.: Spatial analysis of tissue immunity and vascularity by light sheet fluorescence microscopy. Nat Protoc 2024.
Yang F, Akhtar MN, Zhang D, El-Mayta R, Shin J, Dorsey JF, Zhang L, Xu X, Guo W, Bagley SJ, Fuchs SY, Koumenis C, Lathia JD, Mitchell MJ, Gong Y, Fan Y.: An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. Sci Adv 2024.
Dong YC, Nieves LM, Hsu JC, Kumar A, Bouché M, Krishnan U, Mossburg KJ, Saxena D, Uman S, Kambayashi T, Burdick JA, Kim MM, Dorsey JF, Cormode DP : Novel Combination Treatment for Melanoma: FLASH Radiotherapy and Immunotherapy Delivered by a Radiopaque and Radiation Responsive Hydrogel Chem Mater 35(22), Nov 2023.
Paul R, Dorsey JF, Fan Y: Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications. Pharmacol Ther. Mar 2022 Notes: PMID: 34480963 PMCID: PMC8844041 (available on 2023-03-01) DOI: 10.1016/j.pharmthera.2021.107985.
Yang AI, Mensah-Brown KG, Shekhtman EF, Kvint S, Wathen CA, Hitti FL, Alonso-Basanta M, Avery SM, Dorsey JF, Y K Lee J.: Gamma Knife radiosurgery for trigeminal neuralgia provides greater pain relief at higher dose rates. J Radiosurg SBRT 2022.
Lee SH, Kao GD, Feigenberg SJ, Dorsey JF, Frick MA, Jean-Baptiste S, Uche CZ, Cengel KA, Levin WP, Berman AT, Aggarwal C, Fan Y, Xiao Y: Multiblock Discriminant Analysis of Integrative 18F-FDG-PET/CT Radiomics for Predicting Circulating Tumor Cells in Early-Stage Non-small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 110(5): 1451-1465, Aug 2021 Notes: doi: 10.1016/j.ijrobp.2021.02.030. Epub 2021.
Mathilde Bouché, Yuxi C Dong, Saad Sheikh, Kimberly Taing, Deeksha Saxena, Jessica C Hsu, Minna H Chen, Ryan D Salinas, Hongjun Song, Jason A Burdick, Jay Dorsey, David P Cormode: Novel Treatment for Glioblastoma Delivered by a Radiation Responsive and Radiopaque Hydrogel. ACS Biomater Sci Eng. Jul 2021 Notes: PMID: 34160196 PMCID: PMC8411482 DOI: 10.1021/acsbiomaterials.1c00385.