Jacob Dubroff, MD, PhD
Associate Professor of Radiology at the Hospital of the University of Pennsylvania
Department: Radiology
Graduate Group Affiliations
Contact information
Hospital of the University of Pennsylvania
Department of Radiology
Division of Nuclear Imaging and Therapy
3400 Spruce Street
1 Silverstein
Philadelphia, PA 19104
Department of Radiology
Division of Nuclear Imaging and Therapy
3400 Spruce Street
1 Silverstein
Philadelphia, PA 19104
Office: 215-662-3041
Fax: 215-349-5843
Fax: 215-349-5843
Email:
dubroff@upenn.edu
dubroff@upenn.edu
Publications
Education:
BAS (Biomedical Engineering)
University of Pennsylvania Philadelphia, PA, 1997.
BA (History and Sociology of Science)
University of Pennsylvania Philadelphia, PA, 1997.
MD (Medicine)
SUNY Upstate Medical University Syracuse, NY, 2006.
PhD (Neuroscience)
SUNY Upstate Medical University Syracuse, NY, 2006.
Permanent linkBAS (Biomedical Engineering)
University of Pennsylvania Philadelphia, PA, 1997.
BA (History and Sociology of Science)
University of Pennsylvania Philadelphia, PA, 1997.
MD (Medicine)
SUNY Upstate Medical University Syracuse, NY, 2006.
PhD (Neuroscience)
SUNY Upstate Medical University Syracuse, NY, 2006.
Description of Research Expertise
Neuroreceptor PET ImagingMolecular Imaging of Neurological and Psychiatric Disease
Addiction
Cardiac PET Imaging
Brain Plasticity
Selected Publications
Dubroff JG, Hsieh CJ, Wiers CE, Lee H, Schmitz A, Li EJ, Schubert EK, Mach RH, and Kranzler HR: [11C]Carfentanil PET Whole-Body Imaging of Mu-Opioid Receptors: A First In-Human Study. J Nucl Med Apr 2025 Notes: accepted.M Muller FM, Li EJ, Daube-Witherspoon ME, Pantel AR, Wiers CE, Dubroff JG, Vanhove C, Vandenberghe S, and Karp JS: Impact of Deep Learning Denoising on Kinetic Modelling for Low-Dose Dynamic PET: Application to Single- and Dual-Tracer Imaging Protocols. European Journal of Nuclear Medicine and Molecular Imaging Mar 2025 Notes: https://doi.org/10.1007/s00259-025-07182-6.
Hsieh CJ, Hou C, Lee H, Tomita C, Schmitz A, Plakas K, Dubroff JG, Mach RH: Total-body imaging of mu-opioid receptors with [11C]carfentanil in non-human primates. Eur J Nucl Med Mol Imaging. May 2024 Notes: DOI: 10.1007/s00259-024-06746-2.
Wetherill RR and Dubroff J: Reply: Molecular Imaging of Pulmonary Inflammation: Claiming That Vaping Is More Harmful Than Smoking Is Unsupported. J Nucl Med 64(6): 995, Jun 2023 Notes: doi: 10.2967/jnumed.123.265570.
Wetheril RR, Doot RK, Young AJ, Lee H, Schubert EK, Wiers CE, Leone FT, Mach RH, Kranzler HR, Dubroff JG: Using 18F-NOS PET Imaging to Measure Pulmonary Inflammation in Electronic and Combustible Cigarette Users: A Pilot Study. J Nucl Med 64(5): 797-802, May 2023 Notes: doi: 10.2967/jnumed.122.264529.
Rojulpote C, Bhattaru A, Jean C, Patel V, Vidula M, Selvaraj S, Chandra A, Dubroff J, Peyster E, Clancy C, Patterson K, Marchlinski F, Rossman M, Goldberg L, and Bravo P : Effect of Timing, Immunotherapy, and Biopsy-Status in Monitoring Therapy Response in Suspected Cardiac Sarcoidosis. JACC: Cardiovascular Imaging 15(11): 1944-1955, Oct 2022.
Love T, Shabalin A, Kember R, Docherty A, Zhou H, Koppelmans V, Gelernter J, Baker A, Hartwell E, Dubroff J, Zubieta JK, and Kranzler HR: Unique and Joint Associations of Polygenic Risk for Major Depression and Opioid Use Disorder with Endogenous Opioid System Function. Neuropsychopharmacology 47(10): 1784-90, Sep 2022 Notes: doi: 10.1038/s41386-022-01325-1.
Doot RK, Young AJ, Nasrallah IN, Wetherill RR, Siderowf A, Mach RH, Dubroff JG: [18F]NOS PET brain imaging suggests elevated neuroinflammation in idiopathic Parkinson’s disease. Cells 11(19): 3081, Sep 2022.
Schroeder JA, Cao Q, Sotirchos VS,Gillman JA, Anderson T, Pilati S, Dubroff JG, Farwell M, Kozlov A, Korhonen K, Pryma DA, Pantel AR: Perfusion-only Imaging in Pregnant Women: A Comparative Reader Study with Implications for Practice Patterns. Medicine 101(39), Sep 2022.
Zuroff L, Wisseb LEM, Glenn T, Xie S, Nasrallah I, Habes M, Dubroff J, de Flores R, Xie L, Yushkevich P, Doshi J, Davatsikos C, Wolka DA, Dasa S, Mechanic-Hamilton D: Self- and partner-reported subjective memory complaints: association with objective cognitive impairment and risk of decline. JAD reports 6(1): 411-430, Jul 2022.