Casim A. Sarkar, PhD
Associate Professor of Bioengineering
Department: Bioengineering
Education:
BS (Chemical Engineering)
University of Texas at Austin, 1997.
PhD (Chemical Engineering)
Massachusetts Institute of Technology, 2002.
Permanent linkBS (Chemical Engineering)
University of Texas at Austin, 1997.
PhD (Chemical Engineering)
Massachusetts Institute of Technology, 2002.
Description of Research Expertise
Please see http://www.seas.upenn.edu/~caslab/ for further information.Selected Publications
Santhosh Palani and Casim A. Sarkar: Integrating extrinsic and intrinsic cues into a minimal model of lineage commitment for hematopoietic progenitors. PLoS Computational Biology 5(9): e1000518, Sep 2009.Peter Milovnik, Davide Ferrari, Casim A. Sarkar, and Andreas Plückthun: Selection and characterization of DARPins specific for the neurotensin receptor 1. Protein Engineering, Design & Selection 22(6): 357-66, Jun 2009.
Casim A. Sarkar, Igor Dodevski, Manca Kenig, Stefan Dudli, Anja Mohr, Emmanuel Hermans, and Andreas Plückthun: Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity. Proceedings of the National Academy of Sciences of the United States of America 105(39): 14808-13, Sep 2008.
Santhosh Palani and Casim A. Sarkar: Positive receptor feedback during lineage commitment can generate ultrasensitivity to ligand and confer robustness to a bistable switch. Biophysical Journal 95(4): 1575-89, Aug 2008.
Susanne Kubetzko, Casim A. Sarkar, and Andreas Plückthun: Protein PEGylation decreases observed target association rates via a dual blocking mechanism. Molecular Pharmacology 68(5): 1439-54, Nov 2005.
Casim A. Sarkar, Ky Lowenhaupt, Peggy J. Wang, Thomas Horan, and Douglas A. Lauffenburger: Parsing the effects of binding, signaling, and trafficking on the mitogenic potencies of granulocyte colony-stimulating factor analogues. Biotechnology Progress 19(3): 955-64, May-Jun 2003.
Margaret S. Ricci, Casim A. Sarkar, Eric M. Fallon, Douglas A. Lauffenburger, and David N. Brems: pH Dependence of structural stability of interleukin-2 and granulocyte colony-stimulating factor. Protein Science 12(5): 1030-8, May 2003.
Casim A. Sarkar and Douglas A. Lauffenburger: Cell-level pharmacokinetic model of granulocyte colony-stimulating factor: implications for ligand lifetime and potency in vivo. Molecular Pharmacology 63(1): 147-58, Jan 2003.
Casim A. Sarkar, Ky Lowenhaupt, Thomas Horan, Thomas C. Boone, Bruce Tidor, and Douglas A. Lauffenburger: Rational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching". Nature Biotechnology 20(9): 908-13, Sep 2002.