UPENN Biomedical Graduate Studies

David A Mankoff, MD, PhD

Matthew J. Wilson Professor of Research Radiology

Department: Radiology

Graduate Group Affiliations

Bioengineering

Contact information

Division of Nuclear Medicine
Department of Radiology
Perelman School of Medicine, University of Pennsylvania
1 Donner, HUP
3400 Spruce Street
Philadelphia, PA 19104

Office: 215-746-4062
Fax: 215-349-5843

Email:
david.mankoff@pennmedicine.upenn.edu

Education:
B.S. (Physics)
Yale University, 1981.
Ph.D. (Bioengineering)
University of Pennsylvania, 1988.
M.D. (Medicine)
University of Pennsylvania, 1988.

Permanent link

SOM Home » BGS Home » Faculty

Description of Research Expertise

Molecular Imaging
Breast Cancer
Quantitative Cancer Imaging and Image Analysis
Translational Clinical Trials

Selected Publications

Mankoff, D., Balogova, S., Dunnwald, L., Dehdashti, F., DeVries, E., Evangelista, L., Van Kruchten, M., Vaz, S. C., Fowler, A., Linden, H., Ulaner, G. A.: Summary: SNMMI Procedure Standard/EANM Practice Guideline for Estrogen Receptor Imaging of Patients with Breast Cancer Using 16alpha-[(18)F]Fluoro-17beta-Estradiol PET. J Nucl Med 65(2): 221-223, 2024.

Zhou, R., Choi, H., Cao, J., Pantel, A., Gupta, M., Lee, H. S., Mankoff, D.: (18)F-Fluciclovine PET Imaging of Glutaminase Inhibition in Breast Cancer Models. J Nucl Med 64(1): 131-136, Jan 2023 Notes: DOI: 10.2967/jnumed.122.264152.

O'Brien, S. R., Edmonds, C. E., Lanzo, S. M., Weeks, J. K., Mankoff, D. A., Pantel, A. R.: (18)F-Fluoroestradiol: Current Applications and Future Directions. Radiographics 43(3): e220143, Mar 2023 Notes: DOI: 10.1148/rg.220143.

Pantel, A. R., Gitto, S. B., Makvandi, M., Kim, H., Medvedv, S., Weeks, J. K., Torigian, D. A., Hsieh, C. J., Ferman, B., Latif, N. A., Tanyi, J. L., Martin, L. P., Lanzo, S. M., Liu, F., Cao, Q., Mills, G. B., Doot, R. K., Mankoff, D. A., Mach, R. H., Lin, L. L., Simpkins, F.: [18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study. Clin Cancer Res 29(8): 1515-1527, Apr 2023 Notes: DOI: 10.1158/1078-0432.CCR-22-1602.

Lee, I. K., Jacome, D. A., Cho, J. K., Tu, V., Young, A. J., Dominguez, T., Northrup, J. D., Etersque, J. M., Lee, H. S., Ruff, A., Aklilu, O., Bittinger, K., Glaser, L. J., Dorgan, D., Hadjiliadis, D., Kohli, R. M., Mach, R. H., Mankoff, D. A., Doot, R. K., Sellmyer, M. A.: Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim. J Clin Invest 132(18): e156679, Sept 2022 Notes: DOI: 10.1172/JCI156679.

Chitalia, R., Viswanath, V., Pantel, A. R., Peterson, L. M., Gastounioti, A., Cohen, E. A., Muzi, M., Karp, J., Mankoff, D. A., Kontos, D.: Functional 4-D clustering for characterizing intratumor heterogeneity in dynamic imaging: evaluation in FDG PET as a prognostic biomarker for breast cancer. Eur J Nucl Med Mol Imaging 2021.

Viswanath, V., Zhou, R., Lee, H., Li, S., Cragin, A., Doot, R. K., Mankoff, D. A., Pantel, A. R.: Kinetic Modeling of (18)F-(2S,4R)4-Fluoroglutamine in Mouse Models of Breast Cancer to Estimate Glutamine Pool Size as an Indicator of Tumor Glutamine Metabolism. J Nucl Med 62(8): 1154-1162, 2021.

Pantel, A. R., Viswanath, V., Daube-Witherspoon, M. E., Dubroff, J. G., Muehllehner, G., Parma, M. J., Pryma, D. A., Schubert, E. K., Mankoff, D. A., Karp, J. S.: PennPET Explorer: Human Imaging on a Whole-Body Imager. J Nucl Med 61(1): 144-151, 2020.

McDonald, E. S., Doot, R. K., Pantel, A. R., Farwell, M. D., Mach, R. H., Maxwell, K. N., Mankoff, D. A.: Positron Emission Tomography Imaging of Poly-(Adenosine Diphosphate-Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial. JAMA Oncol April 2020.

Elmi, A., Makvandi, M., Weng, C. C., Hou, C., Clark, A. S., Mach, R. H., Mankoff, D. A.: Cell-Proliferation Imaging for Monitoring Response to CDK4/6 Inhibition Combined with Endocrine-Therapy in Breast Cancer: Comparison of [(18)F]FLT and [(18)F]ISO-1 PET/CT. Clin Cancer Res 25(10): 3063-3073, 2019.