Paul J Planet, Ph.D, M.D.

faculty photo
Assistant Professor of Pediatrics (Infectious Diseases)
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
3615 Civic Center Blvd
Abramson 1202A
Philadelphia, PA 19104
Office: 9175140695
Education:
BS (Molecular Biophysics & Biochemistry and Anthropology)
Yale University, 1996.
Ph.D (Integrated Program for Cellular, Molecular, and Biophysical Studies)
Columbia University College of Physicians & Surgeons, 2003.
MD
Columbia University College of Physicians & Surgeons, 2004.
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Description of Research Expertise

Paul J. Planet MD, PhD is an Assistant Professor of Pediatrics at the Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania. He is also a senior researcher at the American Museum of Natural History.

Dr. Planet graduated from Yale University with a Bachelors degree in Anthropology and Molecular Biochemistry & Biophysics. He went on to earn his MD and PhD from Columbia University, where he also completed his residency and fellowship training at the Children’s Hospital of New York. His first faculty appointment was in the division of Pediatric Infectious Disease at Columbia University.

Dr. Planet’s research program focuses on the evolution and ecology of infectious disease. His current interests include the evolution and spread of antibiotic resistant strains, particularly community acquired MRSA, and the impact of the pulmonary microbiome in cystic fibrosis. Dr. Planet’s laboratory uses whole genome phylogenetics, high-throughput sequencing, and bioinformatics to generate hypotheses that are then tested with bench-based microbiology and molecular techniques.

Selected Publications

Esteves,MAC Carvalho,MF Viana,AS Martini,CL Longo,LGA Silva,DNS Ferreira,ALP Ferreira-Carvalho, BT Planet,PJ Figueiredo,AMS: Decoding the evolutionary history of ST30 Staphylococcus aureus: insights into a potentially silent MSSA bloodstream pathogen. Frontiers in Microbiology 16, April 2025 Notes: doi.org/10.3389/fmicb.2025.1522747.

Martínez JRW, Alcalde-Rico M, Jara-Videla E, Reyes J, Carvajal LP, Rincon S, Ríos R, Diaz L, Quesille-Villalobos A, Riquelme-Neira R, Rivas L, Moustafa AM, Hanson B, Undurraga EA, Olivares-Pacheco J, García P, Araos R, Planet PJ, Arias CA, Munita JM: Geographic divergence of methicillin-resistant Staphylococcus aureus ST5-SCCmecI in the aftermath of a major earthquake and tsunami: impact of a plasmid harboring heavy metal resistance genes. MBio Page: doi: 10.1128/mbio.03669-24, April 2025 Notes: epub.

Hecht AL, Mahmud N, Chaudhry S, Cao JY, Branigan GP, Lee J, Theiller E, Roggiani M, Friedman ES, Herman L, Galis BE, Jones SM, Planet PJ, Zackular JP, Kaplan DE, Serper M, Rajender Reddy K, Moustafa AM, Goulian M, Wu GD: Carbohydrate consumption drives adaptive mutations in Escherichia coli associated with increased risk for systemic infection. bioRxiv March 2025 Notes: DOI: 10.1101/2025.03.26.645536.

Narechania A, Bobo D, DeSalle R, Mathema B, Kreiswirth B, Planet PJ: What do we gain when tolerating loss? The information bottleneck wrings out recombination. Mol Biol Evol 42(3): msaf029, March 2025.

Lubin JB, Planet PJ*, Silverman MA : Microbial succession at weaning is guided by microbial metabolism of host glycans. bioRxiv February 2025 Notes: DOI: 10.1101/2025.02.20.639370.

She Q., Srinivasan L., Theiller E., Galis B.E., Napper T., Feder A., Arvanitis A., Jones S.M., Hayes E., Puopolo K.M., Baldassano R.N., David M.Z., Coffin S.E., Gibbs K.A., Smith K., Harris R.M., Zackular J.P., Moustafa A.M., Planet P.J.: Transmission of Staphylococcus aureus in the neonatal intensive care unit predicts invasive infection. medRxiv February 2025 Notes: DOI 10.1101/2025.02.26.25322462.

Zirbes CF, Feder A, Pamatmat AJ, Bartels AR, Pitcher NJ, Rozen AL, Teresi M, Krogh J, Regan M, Arnold EA, Hill JJ, Reinhardt LD, Oberto CL, Boyken L, Reeb VC, Moustafa AM, Planet PJ, Fischer AJ.: Genetic Concordance of Staphylococcus aureus From Oropharyngeal and Sputum Cultures in People With Cystic Fibrosis. Pediatr Pulmonol 60(1): e27475, January 2025.

Zhang SL, McGann CM, Duranova T, Strysko J, Steenhoff AP, Gezmu A, Nakstad B, Arscott-Mills T, Bayani O, Moorad B, Tlhako N, Richard-Greenblatt M, Planet PJ, Coffin SE, Silverman MA.: Maternal and neonatal IgG against Klebsiella pneumoniae are associated with broad protection from neonatal sepsis: a case-control study of hospitalized neonates in Botswana. PLOS Glob Public Health Page: doi: 10.1101/2024.05.28.24308042, December 2024.

Narechania A, Bobo D, Deitz K, DeSalle R, Planet PJ, Mathema B: Rapid SARS-COV2 surveillance using clinical, pooled, or wastewater sequence as a sensor for population change. Genome Res 34(10): 1651-1660, October 2024.

Alameh M, Semon, A, Bayard NU, Pan Y, Knox J, Dwivedi G, Glover RC, Rangel PC, Tanes C, Bittinger K, She Q, Maslanka JR, Planet PJ, Moustafa AM, Davis B, Chevrier A, Beattie M, Ni H, Blizard G, Furth EE, Mach RH, Lavertu M, Sellmyer M, Tam Y, Abt MC, Weissman D, Zackular JP : A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection. Science 386(6717): 69-75, October 2024.

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Last updated: 04/22/2025
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