19
1
49
2
8
1b
1d
18
33
3e
1d
2 29
1d
25
D. Kacy Cullen, Ph.D.
78
3e
Professor of Neurosurgery
7
63
Department: Neurosurgery
4
1
23
1f
Graduate Group Affiliations
8
b
-
64
- Neuroscience 6a
- Pharmacology 41
- Bioengineering e
1d
46
Contact information
48
4
3
3
3
2
29
48
Department of Neurosurgery
35 University of Pennsylvania School of Medicine
44 105 Hayden Hall / 3320 Smith Walk
Philadelphia, PA 19104
26
35 University of Pennsylvania School of Medicine
44 105 Hayden Hall / 3320 Smith Walk
Philadelphia, PA 19104
2e
Office: 215-746-8176
32 Fax: 215-573-3808
24
99
32 Fax: 215-573-3808
24
Email:
dkacy@pennmedicine.upenn.edu
12
dkacy@pennmedicine.upenn.edu
Links
61 Cullen Lab Website
62 National Neurotrauma Society
68 American Society for Mechanical Engineers
85 Center for Brain Injury & Repair, University of Pennsylvania
56 Society for Neuroscience
5d Biomedical Engineering Society
59 Brain Injury Association
6b Traumatic Brain Injury Resource Guide
c
4
b
1f
61 Cullen Lab Website
62 National Neurotrauma Society
68 American Society for Mechanical Engineers
85 Center for Brain Injury & Repair, University of Pennsylvania
56 Society for Neuroscience
5d Biomedical Engineering Society
59 Brain Injury Association
6b Traumatic Brain Injury Resource Guide
c
13
Education:
21 9 B.S. 23 (Mechanical Engineering) c
38 Georgia Institute of Technology, 2000.
21 9 M.S. 23 (Mechanical Engineering) c
38 Georgia Institute of Technology, 2002.
21 a Ph.D. 23 (Biomedical Engineering) c
38 Georgia Institute of Technology, 2005.
c
3
3
3
3
92
Permanent link21 9 B.S. 23 (Mechanical Engineering) c
38 Georgia Institute of Technology, 2000.
21 9 M.S. 23 (Mechanical Engineering) c
38 Georgia Institute of Technology, 2002.
21 a Ph.D. 23 (Biomedical Engineering) c
38 Georgia Institute of Technology, 2005.
c
2 29
21
1e
1d
24
5e
8
3ce The Cullen Lab's objective in Regenerative Medicine is to build anatomically- and developmentally-inspired living tissue to functionally replace lost tissue or augment the body’s capacity for regeneration. Here, focus is given to novel biofabrication strategies for tissue engineered brain and spinal cord pathways as well as "living scaffolds" for neuroregeneration. In Neural Engineering, the objective is to leverage neural tissue engineering strategies to develop "biohybrid" neuroprosthetic interface technology, enable synaptically-based neuromodulation using biological constructs, and provide optical control of neural circuitry. In Neurotrauma, the objective is to apply engineering principles to increase our understanding of the causative mechanisms and pathophysiological responses following traumatic injury to the nervous system. Specific attention is given to neural injury biomechanics and mechanisms of acute biophysical cellular/tissue damage.
8
cb Dr. Cullen is currently an active member of the Biomedical Engineering Society, the American Society of Mechanical Engineers, the National Neurotrauma Society, and the Society for Neuroscience.
8
24 Cullen Lab Research Thrusts:
8
f2 Tissue Engineering & Regenerative Medicine – microtissue engineering to restore brain circuitry; “living scaffolds” for neural regeneration; tissue engineered disease models; neuromuscular repair; translational biomanufacturing
8
a9 Neural Engineering – living biological electrodes for brain-machine interface; “biohybrid” neuroprosthetic interfaces; biologically-based neuromodulation
8
bf Neurotrauma – traumatic brain injury (TBI); spinal cord injury (SCI); peripheral nerve injury (PNI); TBI biomechanics & cell injury mechanisms; neuroinflammation; large animal models
e 29
27
Description of Research Expertise
144 Dr. Cullen is a Professor of Neurosurgery and Bioengineering (with tenure) at the Perelman School of Medicine at the University of Pennsylvania. Dr. Cullen’s research program operates at the intersection of Regenerative Medicine, Neural Engineering, and Neurotrauma (http://www.med.upenn.edu/cullenlab/).8
3ce The Cullen Lab's objective in Regenerative Medicine is to build anatomically- and developmentally-inspired living tissue to functionally replace lost tissue or augment the body’s capacity for regeneration. Here, focus is given to novel biofabrication strategies for tissue engineered brain and spinal cord pathways as well as "living scaffolds" for neuroregeneration. In Neural Engineering, the objective is to leverage neural tissue engineering strategies to develop "biohybrid" neuroprosthetic interface technology, enable synaptically-based neuromodulation using biological constructs, and provide optical control of neural circuitry. In Neurotrauma, the objective is to apply engineering principles to increase our understanding of the causative mechanisms and pathophysiological responses following traumatic injury to the nervous system. Specific attention is given to neural injury biomechanics and mechanisms of acute biophysical cellular/tissue damage.
8
cb Dr. Cullen is currently an active member of the Biomedical Engineering Society, the American Society of Mechanical Engineers, the National Neurotrauma Society, and the Society for Neuroscience.
8
24 Cullen Lab Research Thrusts:
8
f2 Tissue Engineering & Regenerative Medicine – microtissue engineering to restore brain circuitry; “living scaffolds” for neural regeneration; tissue engineered disease models; neuromuscular repair; translational biomanufacturing
8
a9 Neural Engineering – living biological electrodes for brain-machine interface; “biohybrid” neuroprosthetic interfaces; biologically-based neuromodulation
8
bf Neurotrauma – traumatic brain injury (TBI); spinal cord injury (SCI); peripheral nerve injury (PNI); TBI biomechanics & cell injury mechanisms; neuroinflammation; large animal models
e 29
23
58 Keating, C. E., Browne, K. D., Cullen, D. K. bd : Dietary manipulation of vulnerability to traumatic brain injury-induced neuronal plasma membrane permeability. Experimental Neurology 340: 113649, Jun 2021.
1bc Katiyar, K. S., Struzyna, L. A. (co-first author), Morand, J. P., Burrell, J. C., Clements, B., Laimo, F. A., Browne, K. D., Kohn, J., Ali, Z., Ledebur, H. C., Smith, D. H., Cullen, D. K.: Tissue engineered axon tracts serve as living scaffolds to accelerate axonal regeneration and functional recovery following peripheral nerve injury in rats. Frontiers in Biotechnology & Bioengineering 26 8: 492, May 2020.
156 Das, S., Browne, K. D., Laimo, F. A., Maggiore, J. C., Hilman M. C., Kaiser, H., Aguilar, C. A., Ali, Z. S., Mourkioti, F., Cullen, D. K.: Pre-innervated tissue engineered muscle promotes a pro-regenerative microenvironment following volumetric muscle loss. Nature Communications Biology 29 3(1): 330, Jun 2020.
b1 Grovola, M. R., Paleologos, N., Wofford, K. L., Harris, J. P., Browne, K. D., Johnson, V. E., Duda, J. E., Wolf, J. A., Cullen, D. K. ac : Mossy cell hypertrophy and synaptic changes in the hilus following mild diffuse brain injury in pigs. J Neuroinflammation 17(1): 44, 2020.
4c Keating, C. E. and Cullen, D. K. 7b : Mechanosensation in traumatic brain injury. Neurobiology of Disease 148: 105210, Jan 2021.
172 Maggiore, J. C., Burrell, J. C. (co-first author), Browne, K. D., Katiyar, K. S., Laimo, F. A., Zarina, A. S., Kaplan, H. M., Rosen, J. M., Cullen, D. K.: Tissue engineered axon-based “living scaffolds” promote survival of spinal cord motor neurons following peripheral nerve repair. J Tissue Engin & Regen Med 31 14(12): 1892-1907, Dec 2020.
b3 Das, S., Gordián-Vélez, W. (co-first author), Ledebur, H. C., Mourkioti, F., Rompolas, P., Chen, H. I., Serruya, M. D., Cullen, D. K. 8f : Innervation: the missing link for biofabricated tissues and organs. npj Regenerative Medicine 5: 11, Jun 2020.
130 Cullen, D. K., Gordián-Vélez, W. J., Struzyna, L. A., Jgamadze, D., Lim, J., Wofford, K. L., Browne, K. D., Chen, H. I.: Bundled three-dimensional human axon tracts derived from cerebral organoids. iScience 21: 57-67, Nov 2019.
17a Struzyna, L. A., Browne, K. D., Brodnik, Z. D., Burrell, J. C., Harris, J. P., Chen, H. I., Wolf, J. A., Panzer, K. V., Lim, J., Duda, J. E., España, R. A., Cullen, D. K.: Tissue engineered nigrostriatal pathway for treatment of Parkinson’s disease. J Tissue Engin & Regen Med 12(7): 1702-16, Jul 2018.
2c
7
1d
1f
Selected Publications
153 Adewole, D. O., Struzyna, L. A., Harris, J. P., Nemes, A. D., Burrell, J. C., Petrov, D., Kraft, R. H., Chen, H. I., Serruya, M. D., Wolf, J. A., Cullen, D. K.: Development of optically-controlled "living electrodes" with long-projecting axon tracts for a synaptic brain-machine interface 44 Science Advances 7(4): eaay5347, Jan 2021.58 Keating, C. E., Browne, K. D., Cullen, D. K. bd : Dietary manipulation of vulnerability to traumatic brain injury-induced neuronal plasma membrane permeability. Experimental Neurology 340: 113649, Jun 2021.
1bc Katiyar, K. S., Struzyna, L. A. (co-first author), Morand, J. P., Burrell, J. C., Clements, B., Laimo, F. A., Browne, K. D., Kohn, J., Ali, Z., Ledebur, H. C., Smith, D. H., Cullen, D. K.: Tissue engineered axon tracts serve as living scaffolds to accelerate axonal regeneration and functional recovery following peripheral nerve injury in rats. Frontiers in Biotechnology & Bioengineering 26 8: 492, May 2020.
156 Das, S., Browne, K. D., Laimo, F. A., Maggiore, J. C., Hilman M. C., Kaiser, H., Aguilar, C. A., Ali, Z. S., Mourkioti, F., Cullen, D. K.: Pre-innervated tissue engineered muscle promotes a pro-regenerative microenvironment following volumetric muscle loss. Nature Communications Biology 29 3(1): 330, Jun 2020.
b1 Grovola, M. R., Paleologos, N., Wofford, K. L., Harris, J. P., Browne, K. D., Johnson, V. E., Duda, J. E., Wolf, J. A., Cullen, D. K. ac : Mossy cell hypertrophy and synaptic changes in the hilus following mild diffuse brain injury in pigs. J Neuroinflammation 17(1): 44, 2020.
4c Keating, C. E. and Cullen, D. K. 7b : Mechanosensation in traumatic brain injury. Neurobiology of Disease 148: 105210, Jan 2021.
172 Maggiore, J. C., Burrell, J. C. (co-first author), Browne, K. D., Katiyar, K. S., Laimo, F. A., Zarina, A. S., Kaplan, H. M., Rosen, J. M., Cullen, D. K.: Tissue engineered axon-based “living scaffolds” promote survival of spinal cord motor neurons following peripheral nerve repair. J Tissue Engin & Regen Med 31 14(12): 1892-1907, Dec 2020.
b3 Das, S., Gordián-Vélez, W. (co-first author), Ledebur, H. C., Mourkioti, F., Rompolas, P., Chen, H. I., Serruya, M. D., Cullen, D. K. 8f : Innervation: the missing link for biofabricated tissues and organs. npj Regenerative Medicine 5: 11, Jun 2020.
130 Cullen, D. K., Gordián-Vélez, W. J., Struzyna, L. A., Jgamadze, D., Lim, J., Wofford, K. L., Browne, K. D., Chen, H. I.: Bundled three-dimensional human axon tracts derived from cerebral organoids. iScience 21: 57-67, Nov 2019.
17a Struzyna, L. A., Browne, K. D., Brodnik, Z. D., Burrell, J. C., Harris, J. P., Chen, H. I., Wolf, J. A., Panzer, K. V., Lim, J., Duda, J. E., España, R. A., Cullen, D. K.: Tissue engineered nigrostriatal pathway for treatment of Parkinson’s disease. J Tissue Engin & Regen Med 12(7): 1702-16, Jul 2018.
2c