Barbara K Schmidt, MD, MSc
Emeritus Professor CE of Pediatrics (Neonatology & Newborn Services)
Department: Pediatrics
Contact information
Hospital of the University of Pennsylvania
Division of Neonatology and Newborn Services
3400 Spruce Street, 8 Ravdin
Philadelphia, PA 19104
Division of Neonatology and Newborn Services
3400 Spruce Street, 8 Ravdin
Philadelphia, PA 19104
Office: (215) 662-3228
Fax: (215) 349-8831
Fax: (215) 349-8831
Education:
MD
Georg-August University, 1976.
MD Thesis
Georg-August University, 1977.
MSc (Clinical Epidemiology and Biostatistics)
McMaster University, 1992.
Permanent linkMD
Georg-August University, 1976.
MD Thesis
Georg-August University, 1977.
MSc (Clinical Epidemiology and Biostatistics)
McMaster University, 1992.
Description of Research Expertise
Barbara Schmidt, MD, MSc, is a Professor of Pediatrics and Senior Scholar in the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania School of Medicine. She is also a staff neonatologist in the Division of Neonatology at the Children’s Hospital of Philadelphia and the University of Pennsylvania Health System.Dr. Schmidt’s research focuses on collaborative neonatal randomized trials that have clinically important, long-term outcomes such as growth and development. Examples of trials she directed in the past include the “Trial of Indomethacin Prophylaxis in Preterms.” In this study, 1,202 extremely low-birth-weight infants from five countries were followed to the end of the second year of life. The results from the study showed that the high rate of mental and motor deficits in these children is not improved by prophylactic treatment with indomethacin. She is also the principal investigator of the “Caffeine for Apnea of Prematurity” trial, which enrolled over 2,000 very low-birth-weight infants in North America, Europe, Israel and Australia. Caffeine has been used for more than 30 years to regulate the breathing of very preterm babies, but without sufficient knowledge of the possible benefits and risks. To date, this trial has shown that caffeine therapy for apnea of prematurity improves the rate of survival without neurodevelopmental disability up to two years after very preterm birth. This study will continue to follow the study participants well into school age.
Since May 2010, Dr. Schmidt is a Co-Principal Investigator of the Data Coordinating Center for the Prematurity and Respiratory Outcomes Program (PROP) sponsored by NHLBI and located at the University of Pennsylvania School of Medicine. One of the goals of this multi-center collaboration is the identification of predictors of respiratory outcomes that may serve as surrogate endpoints in future trials of prevention and therapy of respiratory diseases in preterm infants. In addition, since April 2011, Dr. Schmidt is the clinical center PI for the University of Pennsylvania and Children’s Hospital of Philadelphia in the reconfigured Neonatal Research Network (NRN) of the Eunice Kennedy Shriver NICHD.
Selected Publications
Schmidt B, Roberts RS, Anderson PJ, Asztalos EV, Costantini L, Davis PG, Dewey D, D'llario J, Doyle LW, Grunau RE, Moddemann D, Nelson H, Ohlsson A, Solimano A, Tin W; Caffeine for Apnea of Prematurity (CAP) Trial Group: Academic Performance, Motor Function, and Behavior 11 Years After neonatal Caffeine Citrate Therapy for Apnea of Prematurity: An 11-Year follow-up of the CAP Randomized Clinical Trial. JAMA Pediatr April 2017.Whyte RK, Nelson H, Roberts RS, Schmidt B: Benefits of Oxygen Saturation Targeting Trials: Oximeter Calibration Software Revision and Infant Saturations. J Pediatr March 2017.
Jensen EA, Dysart KC, Gantz MG, Carper B, Higgins RD, Keszler M, Laughon MM, Poindexter BB, Stoll BJ, Walsh MC, Schmidt B; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network: Association Between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants. J Pediatr February 2017.
Jensen EA, Panitch H, Feng R, Moore PE, Schmidt B: Interobserver Reliability of the Respiratory Physical Examination in Premature Infants: A Multicenter Study. J Pediatr November 2016.
Schmidt B, Whyte RK, Shah PS, Abbasi S, Bairam A, Harrold J, Roberts RS; Canadian Oxygen Trial (COT) Group: Effects of Targeting Higher or Lower Oxygen Saturations in Centers with More Versus Less Separation between Median Saturations. J Pediatr November 2016.
Das A, Tyson J, Pedroza C, Schmidt B, Gantz M, Wallace D, Truog WE, Higgins RD: Methodological Issues in the Design and Analyses of Neonatal Research Studies: Experience of the NICHD Neonatal Research Network. Semin Perinatol June 2016.
Poindexter BB, Feng R, Schmidt B, Aschner JL, Ballard RA, Hamvas A, Reynolds AM, Shaw PA, Jobe AH: Comparisons and Limitations of Current Definitions Bronchopulmonary Dysplasia. Ann Am Thorac Soc December 2015 Notes: Prematurity and Respiratory Outcomes Program.
Schmidt B, Roberts RS, Davis PG, Doyle LW, Asztalos EV, Opie G, Bairam A, Solimano A, Arnon S, Sauve RS: Prediction of Late Death or Disability at Age 5 Years Using a Count of 3 Neonatal Morbidities in Very Low Birth Weight Infants. J Pediatr November 2015 Notes: Caffeine for Apnea of Prematurity (CAP) Trial Investigators
Poets CF, Roberts RS, Schmidt B, Whyte RK, Asztalos EV, Bader D, Bairam A, Moddemann D, Peliowski A, Rabi Y, Solimano A, Nelson H: Association Between Intermittent Hypoxemia or Bradycardia and Late Death or Disability in Extremely Preterm Infants. JAMA August 2015 Notes: Canadian Oxygen Trial Investigators.
Synnes A, Anderson PJ, Grunau RE, Dewey D, Moddemann D, Tin W, Davis PG, Doyle LW, Foster G, Khairy M, Nwaesei C, Schmidt B: Predicting severe motor impairment in preterm children at age 5 years. Arch Dis Child August 2015 Notes: CAP Trial Investigator group.