David B. Frank, MD, PhD
Assistant Professor of Pediatrics (Cardiology)
Department: Pediatrics
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
Division of Cardiology
3401 Civic Center Blvd, 8NW37
Philadelphia, PA 19104
Division of Cardiology
3401 Civic Center Blvd, 8NW37
Philadelphia, PA 19104
Office: (267) 648-2626
Fax: 215-590-1340
Fax: 215-590-1340
Publications
Education:
BS (Biochemistry)
University of Nebraska-Lincoln, 1997.
PhD (Cell and Developmental Biology and Philosophy)
Vanderbilt University School of Medicine, 2006.
MD
Vanderbilt University of School of Medicine, 2009.
Permanent linkBS (Biochemistry)
University of Nebraska-Lincoln, 1997.
PhD (Cell and Developmental Biology and Philosophy)
Vanderbilt University School of Medicine, 2006.
MD
Vanderbilt University of School of Medicine, 2009.
Selected Publications
Marzolini N, Brysgel TV, Rahman RJ, Essien EO, Nwe SY, Wu J, Majumder A, Patel MN, Tiwari S, Espy CL, Dong F, Santos-De León SA, Shah A, Shuvaev VV, Hood ED, Chase LS, Weissman D, Katzen JB, Frank DB, Bennett ML, Marcos-Contreras OA, Myerson JW, Muzykantov VR, Reyes-Esteves S, Brenner JS. : Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity. Advanced Science 13(14): e15480, March 2026.Wen H, Liberti DC, Chandrasekaran P, Parveen S, Quansah KK, Kim M, Lange AN, Marquis AT, Michki SN, Jin A, Lu M, Fasan AA, Suresh S, Shirazi SP, Young LR, Sucre JM, Basil MC, Jain R, Frank DB.: BRD4 promotes endodermal cell fate during mammalian lung development. JCI Insight 11(5): e194683, March 2026.
Snitow ME, Michki SN, Chaudhry FN, Park Y, Dherwani R, Katzen JB, Frank DB, Zepp JA: Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through apoptosis in the neonatal lung. Cell Rep 45(1): 116750, January 2026.
Meluskey H, Blowey B, O'Brien AB, O'Byrne ML, Rome JJ, Frank DB, Avitabile CM, Gupta M, Tang J, Butler KL, Mavroudis CD, Fuller S, Callahan R. : Systemic Sirolimus Monitoring in Pediatric Pulmonary Vein Stenosis. Pediatr Cardiol. Page: doi: 10.1007/s00246-025-04038-6, October 2025.
Niccum M, Avitabile CM, Albizem D, Meluskey H, Penney C, Hanna BD, O'Byrne ML, Bshouty Z, Frank DB. Pulmonary Vascular Compromise Is Associated With Survival in Pediatric Pulmonary Hypertension: A New Computational Model. Pulm Circ. 2025 Sep 1;15(3):e70156. doi: 10.1002/pul2.70156. PMID: 40904895; PMCID: PMC12401941.: Pulmonary Vascular Compromise Is Associated With Survival in Pediatric Pulmonary Hypertension: A New Computational Model. Pulm Circ. 15(3): e70156, September 2025 Notes: Editorial accompaniment in Pulmonary Circulation https://onlinelibrary.wiley.com/doi/10.1002/pul2.70218.
Chen C, Xu J, Sussman JH, Vincent T, Tumulty JS, Yoshimura S, Alikarami F, Yu W, Ding YY, Chen CH, Li EY, Yang A, Qin X, Bandyopadhyay S, Peng J, Pölönen P, Newman H, Wood BL, Hu J, Shraim R, Hughes AD, Diorio C, Uppuluri L, Shi G, Ryan T, Fuller T, Loh ML, Raetz EA, Hunger SP, Pounds SB, Mullighan CG, Frank D, Yang JJ, Bernt KM, Teachey DT, Tan K.: Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome. Blood 145(23): 2685-2700, June 2025.
Vega TF, Huber M, Jensen EA, Avitabile CM, Lorch SA, Gibbs KA, O'Byrne ML, Frank DB, Bamat NA: Pulmonary vasodilator use in very preterm infants in United States children's hospitals. J Perinatol 45(10): 1382-1388, May 2025.
Shirazi SP, Negretti NM, Jetter CS, Sharkey AL, Garg S, Kapp ME, Wilkins D, Fortier G, Mallapragada S, Banovich NE, Eldredge LC, Deutsch GH, Wright CVE, Frank DB, Kropski JA, Sucre JMS: Bronchopulmonary dysplasia with pulmonary hypertension associates with semaphorin signaling loss and functionally decreased FOXF1 expression. Nat Commun 16(1): 5004, May 2025.
Wen J., Chandrasekaran P., Jin A., Pankin J., Lu M., Liberti D.C., Zepp J.A., Jain R., Morrisey E.E., Michki S.N., Frank D.B. : A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during development. Cell Rep 44(4): 115513, April 2025.
Maureen Peers de Nieuwburgh, Mallory Hunt, Prashant Chandrasekaran, Tiffaney L Vincent, Kevin B Hayes, Isabel R Randazz, Meredith Gunder , Felix R De Bie, Arthur Colson, Minqi Lu, Hongbo Wen, Sylvia N Michki, Jack Rychik , Fréderic Debiève, Jeremy Katzen, Lisa R Young, Marcus G Davey, Alan W Flake, J William Gaynor, David B Frank: Chronic Hypoxia in an EXTrauterine Environment for Neonatal Development Impairs Lung Development. Am J Respir Cell Mol Biol 72(4): 441-452, April 2025.

