Arjun Raj, PhD
Professor of Genetics
Department: Genetics
Graduate Group Affiliations
Contact information
office: 415A Clinical Research Building (CRB)
415 Curie Boulevard
Philadelphia, PA 19104
lab: 415/420 Clinical Research Building (CRB)
415 Curie Boulevard
Philadelphia, PA 19104
415 Curie Boulevard
Philadelphia, PA 19104
lab: 415/420 Clinical Research Building (CRB)
415 Curie Boulevard
Philadelphia, PA 19104
Office: 215-821-7394
Email:
arjunraj@seas.upenn.edu
arjunraj@seas.upenn.edu
Publications
Education:
BA (Physics and Mathematics)
University of California, Berkeley, 2000.
PhD (Mathematics)
Courant Institute of Mathematical Sciences, New York University, 2006.
Permanent linkBA (Physics and Mathematics)
University of California, Berkeley, 2000.
PhD (Mathematics)
Courant Institute of Mathematical Sciences, New York University, 2006.
Description of Research Expertise
Research Interests: RNA systems biology, particular as related to non-coding RNAs and cancer biology.Keywords: RNA, systems biology, cancer, non-coding RNAs
Research Details:
The Raj lab studies the biology of single cells. The primary motivation for studying biological processes on a cell-by-cell basis is the fact that even genetically identical cells can behave very differently. This variability can have consequences in a variety of biological contexts. We aim to understand these differences at the molecular level. We develop and utilize a mix of experimental tools including individual RNA molecules via fluorescence microscopy, high throughput sequencing and molecular biology to make quantitative measurements of cellular behavior.
Rotation Projects: Please contact Arjun for more details.
Selected Publications
Golubic R, Mumbole H, Ismail MH, Choo A, Baker O, Atha K, Mei SCS, Raj A, Anand P, Aung NO, Kumar NS, Nahar T, Coleman RL, Tomlinson JW, Rahman N, Caleyachetty R, Adler A.: Glucocorticoid treatment and new-onset hyperglycaemia and diabetes in people living with chronic obstructive pulmonary disease: A systematic review and meta-analysis. Diabet Med 42(3): e15475, Mar 2025.Alexander KA, Yu R, Skuli N, Coffey NJ, Nguyen S, Faunce CL, Huang H, Dardani IP, Good AL, Lim J, Li CY, Biddle N, Joyce EF, Raj A, Lee D, Keith B, Simon MC, Berger SL.: Nuclear speckles regulate functional programs in cancer. Nat Cell Biol 27(2): 322-335, Feb 2025.
Kinsler G, Fagan C, Li H, Kaster J, Dunne M, Vander Velde RJ, Boe RH, Shaffer S, Herlyn M, Raj A, Heyman Y.: SpaceBar enables clone tracing in spatial transcriptomic data. bioRxiv Feb 2025.
Niu Z, O'Farrell A, Li J, Reffsin S, Jain N, Dardani I, Goyal Y, Raj A.: Piscis: a novel loss estimator of the F1 score enables accurate spot detection in fluorescence microscopy images via deep learning. bioRxiv Jan 2025.
O'Farrell A, Niu Z, Li J, Van Eyndhoven LC, Sarma K, Raj A.: Innate Immune Memory is Stimulus Specific. bioRxiv Jan 2025.
Tayyil Purayil AL, Joseph RM, Raj A, Kooriyattil A, Jabeen N, Beevi SF, Lathief N, Latheif F.: Role of Artificial Intelligence in MRI-Based Rectal Cancer Staging: A Systematic Review. Cureus 16: e76185, Dec 2024.
Raj AK, Pedersen SJ, Mainsbridge C, Rao CR, Roy S, Chandrasekaran B.: Influence of short bouts of stair climbing on young adults during prolonged sitting on posture, discomfort, and musculoskeletal performance outcomes: a counterbalanced pilot randomised crossover trial. Ergonomics 67(11): 1415-1426, Nov 2024.
Boe RH, Triandafillou CG, Lazcano R, Wargo JA, Raj A.: Spatial transcriptomics reveals influence of microenvironment on intrinsic fates in melanoma therapy resistance. bioRxiv Jul 2024.
Li J, Ravindran PT, O'Farrell A, Busch GT, Boe RH, Niu Z, Woo S, Dunagin MC, Jain N, Goyal Y, Sarma K, Herlyn M, Raj A.: AP-1 Mediates Cellular Adaptation and Memory Formation During Therapy Resistance. bioRxiv Jul 2024.
Coté A, O'Farrell A, Dardani I, Dunagin M, Coté C, Wan Y, Bayatpour S, Drexler HL, Alexander KA, Chen F, Wassie AT, Patel R, Pham K, Boyden ES, Berger S, Phillips-Cremins J, Churchman LS, Raj A.: Post-transcriptional splicing can occur in a slow-moving zone around the gene. Elife 12: RP91357, Apr 2024.