Russell Takeshi Shinohara, Ph.D.
Professor of Biostatistics and Epidemiology
Department: Biostatistics and Epidemiology
Graduate Group Affiliations
Contact information
Center for Clinical Epidemiology and Biostatistics
Department of Biostatistics, Epidemiology and Informatics
Perelman School of Medicine
University of Pennsylvania
217 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
Department of Biostatistics, Epidemiology and Informatics
Perelman School of Medicine
University of Pennsylvania
217 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
Office: 215-746-1090
Fax: 215-573-1050
Fax: 215-573-1050
Email:
rshi@pennmedicine.upenn.edu
rshi@pennmedicine.upenn.edu
Education:
Honors BSc (Probability and Statistics)
McGill University, 2006.
MSc (Mathematics and Statistics)
McGill University, 2007.
PhD (Biostatistics)
The Johns Hopkins University, 2012.
Permanent linkHonors BSc (Probability and Statistics)
McGill University, 2006.
MSc (Mathematics and Statistics)
McGill University, 2007.
PhD (Biostatistics)
The Johns Hopkins University, 2012.
Selected Publications
Roalf, DR, Atkins, A, Czernuszenko, A, Pecsok MK, McDonald-McGinn, DM, Schmitt JE, Roeske MJ, Hopkins S, Freedman P, Alexander-Bloch A, Schabdach J, Jung B, Crowley TB, Gallagher RS, McGinn DE, Moberg PJ, Ruparel K, Shinohara RT, Turetsky BI, White L, Zackai EH, Gur RC, Gur RE: Presence, severity, and functional associations of incomplete hippocampal inversion in 22q11.2 deletion syndrome. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Apr 2025 Notes: doi: 10.1016/j.bpsc.2025.04.009. Epub ahead of print.Baller EB, Luo AC, Schindler MK, Cooper EC, Pecsok MK, Cieslak MC, Martin ML, Bar-Or A, Elahi A, Perrone CM, Spangler BC, Satterthwaite TD, Shinohara RT: Uncinate Fasciculus Lesion Burden and Anxiety in Multiple Sclerosis. JAMA Network Open 8(4), Apr 2025.
Manning AR, Letchuman V, Martin ML, Gombos E, Robert-Fitzgerald T, Cao Q, Raza P, O'Donnell CM, Renner B, Daboul L, Rodrigues P, Ramos M, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi PA, Cree BAC, Freeman L, Henry RG, Longbrake EE, Oh J, Papinutto N, Pelletier D, Samudralwar RD, Suthiphosuwan S, Schindler MK, Bilello M, Song JW, Sotirchos ES, Sicotte NL, Al-Louzi O, Solomon AJ, Reich DS, Ontaneda D, Sati P, Shinohara RT; NAIMS Cooperative: Multicenter Automated Central Vein Sign Detection Performs as Well as Manual Assessment for the Diagnosis of Multiple Sclerosis. American Journal of Neuroradiology 46(3): 620-626, Mar 2025.
Puvvula J, Hwang WT, McCandless L, Xie C, Braun JM, Vuong AM, Oulhote Y, Schisterman EF, Shinohara RT, Booij L, Bouchard MF, Linn K, Borghese MM, Seguin JR, Zidek A, Till C, Fraser W, Yolton K, Cecil KM, Ashley-Martin J, Arbuckle TE, Lanphear B, Chen A: Gestational exposure to environmental chemical mixtures and cognitive abilities in children: A pooled analysis of two North American birth cohorts Environmental International 196: 109298, Feb 2025 Notes: doi: 10.1016/j.envint.2025.109298. Epub 2025 Jan 29.
Ripart M, Spitzer H, Williams LZJ, Walger L, Chen A, Napolitano A, Rossi- Espagnet C, Foldes ST, Hu W, Mo J, Likeman M, Rüber T, Caligiuri ME, Gambardella A, Guttler C, Tietze A, Lenge M, Guerrini R, Cohen NT, Wang I, Kloster A, Pinborg LH, Hamandi K, Jackson G, Tortora D, Tisdall M, Conde-Blanco E, Pariente JC, Perez-Enriquez C, Gonzalez-Ortiz S, Mullatti N, Vecchiato K, Liu Y, Kalviainen R, Sokol D, Shetty J, Sinclair B, Vivash L, Willard A, Winston GP, Yasuda C, Cendes F, Shinohara RT, Duncan JS, Cross JH, Baldeweg T, Robinson EC, Iglesias JE, Adler S, Wagstyl K; MELD FCD writing group; Fawaz A, De Benedictis A, De Palma L, Zhang K, Labate A, Barba C, You X, Gaillard WD, Tang Y, Wang S, Davies S, Semmelroch M, Severino M, Striano P, Chari A, D'Arco F, Mankad K, Bargallo N, Pascual-Diaz S, Delgado-Martinez I, O'Muircheartaigh J, Abela E, Kandasamy J, McLellan A, Desmond P, Lui E, O'Brien TJ, Whitaker K: Detection of Epileptogenic Focal Cortical Dysplasia Using Graph Neural Networks: A MELD Study. JAMA Neurology Page: e245406, Feb 2025 Notes: doi: 10.1001/jamaneurol.2024.5406. Epub ahead of print.
Martin ML, Cao Q, Luskin E, Renner B, Daboul L, O'Donnell CM, Rodrigues P, Derbyshire J, Azevedo CJ, Bar-Or A, Caverzasi E, Calabresi P, Cree BAC, Freeman L, Henry RG, Longbrake EE, Oh J, Papinutto N, Pelletier D, Prchkovska V, Ramos M, Samudralwar RD, Schindler MK, Sotirchos ES, Sicotte NL, Solomon AJ, Reich DS, Ontaneda D, Shinohara RT, Sati P: Reliability of Central Vein Sign Imaging With 3T FLAIR* in a Multicenter Study. Journal of Neuroimaging 35(1): e70011, Jan-Feb 2025.
Pecsok MK, Robinson H, Atkins A, Calkins ME, Elliott MA, Mordy A, Stifelman J, Gur RC, Moberg PJ, Nanga RPR, Ruparel K, Shinohara RT, Wolk DA, Reddy R, Roalf DR: Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging. Frontiers in Aging Neuroscience 16: 1535158, Jan 2025.
Gugger JJ, Kulick-Soper C, Sinha N, Jaskir M, Hadar P, Josyula M, Petillo N, Raghupathi R, Shinohara RT, Das S, Stein J, Davis KA: Evaluation of Limbic Microstructural Abnormalities in Temporal Lobe Epilepsy: A NODDI Study. Epilepsia In press 2025.
Zenk, M., Baid, U., Pati, S., Linardos, A., Edwards, B., Sheller, M., Foley, P., Aristizabal, A., Zimmerer, D., Gruzdev, A., Martin, J., T, R., Reinke, A., Isensee, F., Parampottupadam, S., Parekh, K., Floca, R., Kassem, H., Baheti, B., Thakur, S., Chung, V., Kushibar, K., Lekadir, K., Jiang, M., Yin, Y., Yang, H., Liu, Q., Chen, C., Dou, Q., Heng, P., Zhang, X., Zhang, S., Irfan, M., Ayyaz, M., Jafaritadi, M., Alhoniemi, E., Kontio, E., A., S., Mächler, L., Ezhov, I., Kofler, F., Shit, S., C., J., Loehr, T., Wiestler, B., Peiris, H., Pawar, K., Zhong, S., Chen, Z., Hayat, M., Egan, G., Harandi, M., Isik, E., Polat, G., Kocyigit, A., Temizel, A., Tuladhar, A., Tyagi, L., Souza, R., D., N., Mouches, P., Wilms, M., Shambhat, V., Maurya, A., Subhas, S., Kalla, R., Kumar, V., Krishnamurthi, G., Nalawade, S., Ganesh, C., Wagner, B., Reddy, D., Das, Y., F, F., Fei, B., J, A., Maldjian, J., Singh, G., Ren, J., Zhang, W., An, N., Hu, Q., Zhang, Y., Zhou, Y., Siomos, V., Rawat, A., Zizzo, G., Kadhe, S., P, J., Braghin, S., Wang, Y., Kanagavelu, R., Wei, Q., Yang, Y., Liu, Y., Kotowski, K., Adamski, S., Machura, B., Malara, W., Zarudzki, L., Nalepa, J., Shi, Y., Gao, H., Avestimehr, S., Yan, Y., S, A., Kondrateva, E., Yang, H., Li, Z., Wu, H., Roth, J., Saueressig, C., Milesi, A., D, Q., J, N., Huang, T., Ma, J., Shwinder, H., Pan, N., Zhang, D., A, R., Futrega, M., Yuan, Y., Marco, G., Feng, X., D, Q., Xia, Y., Jiang, Z., Minh, H., Dobko, M., Carré, A., Tuchinov, B., Mohy-ud-Din, H., Alam, S., Singh, A., Shah, N., Wang, W., Sako, C., Bilello, M., Ghodasara, S., Mohan, S., Davatzikos, C., Calabrese, E., Rudie, J., Villanueva-Meyer, J., Cha, S., Hess, C., Mongan, J., Ingalhalikar, M., Jadhav, M., Pandey, U., Saini, J., Y, R., Chang, K., To, M., Bhardwaj, S., Chong, C., Agzarian, M., Kozubek, M., Lux, F., Michálek, J., Matula, P., Keřkovský, M., Kopřivová, T., Dostál, M., Vybíhal, V., C, M., Holcomb, J., Metz, M., Jain, R., Lee, M., W, Y., Tiwari, P., Verma, R., Bareja, R., Yadav, I., Chen, J., Kumar, N., Gusev, Y., Bhuvaneshwar, K., Sayah, A., Bencheqroun, C., Belouali, A., Madhavan, S., R, R., Kotrotsou, A., Vollmuth, P., Brugnara, G., J, C., Sahm, F., Bendszus, M., Wick, W., Mahajan, A., Balaña, C., Capellades, J., Puig, J., Seong, Y., Lee, S., Hee, J., Soo, S., F, H., Herrera-Trujillo, A., Trujillo, M., Escobar, W., Abello, A., Bernal, J., Gómez, J., LaMontagne, P., Marcus, D., Milchenko, M., Nazeri, A., Landman, B., Ramadass, K., Xu, K., Chotai, S., B, L., Mistry, A., C, R., Srinivasan, A., Rajiv, J., Rao, A., Wang, N., Yoshiaki, O., Moritani, T., Turk, S., Lee, J., Prabhudesai, S., Garrett, J., Larson, M., Jeraj, R., Li, H., Weiss, T., Weller, M., Bink, A., Pouymayou, B., Sharma, S., Tseng, T., Adabi, S., Xavier, A., B, S., C., B., Sprenger, F., Menotti, D., R, D., P, S., Keunen, O., Hau, A., Pelaez, E., Franco-Maldonado, H., Loayza, F., Quevedo, S., McKinley, R., Slotboom, J., Radojewski, P., Meier, R., Wiest, R., Trenkler, J., Pichler, J., Necker, G., Haunschmidt, A., Meckel, S., Guevara, P., Torche, E., Mendoza, C., Vera, F., Ríos, E., López, E., A, S., Choi, J., Baek, S., Kim, Y., Ismael, H., Allen, B., M, J., Zampakis, P., Panagiotopoulos, V., Tsiganos, P., Alexiou, S., Haliassos, I., I, E., Moustakas, K., Kalogeropoulou, C., M, D., Luo, B., Poisson, L., Wen, N., Vallières, M., Ait, M., Fortin, D., Lepage, M., Morón, F., Mandel, J., Shukla, G., Liem, S., S, G., Lombardo, J., D, J., E, A., P, A., Ogbole, G., Oyekunle, D., Odafe-Oyibotha, O., Osobu, B., Shu’aibu, M., Soneye, M., Dako, F., Dorcas, A., Murcia, D., Fu, E., Haas, R., Thompson, J., Ryan, D., Currie, S., Fatania, K., Frood, R., L, A., J, J., Hu, R., Cutler, D., Y, F., Tran, A., Hamghalam, M., A, M., Gimpel, J., Kattil, D., Schmidt, K., Cimino, L., Price, C., Bialecki, B., Marella, S., Apgar, C., Jakab, A., Weber, M., Colak, E., Kleesiek, J., B, J., S, J., Maier-Hein, L., Albrecht, J., Mattson, P., Karargyris, A., Shah, P., Menze, B., Maier-Hein, K., Bakas, S.: Towards Fair Decentralized Benchmarking of Healthcare AI Algorithms with the Federated Tumor Segmentation (FeTS) Challenge. Nature Communications In press 2025.
Solomon AJ, Weinstein S, Shinohara RT, Aoun SM, Schmidt H, Solari A: Diagnostic Delay and Misdiagnosis of Symptoms Reported by Patients with Multiple Sclerosis Participating in a Research Registry. Multiple Sclerosis Journal – Experimental, Translational and Clinical In press 2025.