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Stefano B Rivella, PhD
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Professor of Pediatrics (Hematology)
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Department: Pediatrics
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Graduate Group Affiliations
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Contact information
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Children’s Hospital of Philadelphia
20 3615 Civic Center Blvd.
2b Abramson Research Center, Room 316B
1e Philadelphia, PA 19104
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46 https://www.med.upenn.edu/apps/faculty/index.php/g275/p8859218
57 https://www.linkedin.com/in/stefano-rivella-9b5a489a
Philadelphia, PA 19104
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20 3615 Civic Center Blvd.
2b Abramson Research Center, Room 316B
1e Philadelphia, PA 19104
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46 https://www.med.upenn.edu/apps/faculty/index.php/g275/p8859218
57 https://www.linkedin.com/in/stefano-rivella-9b5a489a
Philadelphia, PA 19104
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Office: 215-590-6840
32 Fax: 267-426-5476
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32 Fax: 267-426-5476
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Email:
rivellas@chop.edu
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rivellas@chop.edu
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Publications
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Links
b5 Search PubMed for articles
d1 La Talassemia: dai Laboratori di Ricerca alla Società (parte quarta)
a0 Reducing TMPRSS6 ameliorates hemochromatosis and beta-thalassemia in mice
c1 European Medicines Agency (EMA), Scientific Committee members and experts
9c Blood Disorders Mechanics Deconstructed
c0 Hormone's Crucial Role in 2 Anemic Blood Disorders Revealed 2 b
103 Researchers Discover Hormone that Controls Supply of Iron in Red Blood Cell Production
60 Development minihepcidin compound
d8 Medgenics Announces Beta Thalassemia Research Program
c0 Perspective: Speed Networking for Scientists
c3 Dr. Rivella and team find new gene therapy approach
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b5 Search PubMed for articles
d1 La Talassemia: dai Laboratori di Ricerca alla Società (parte quarta)
a0 Reducing TMPRSS6 ameliorates hemochromatosis and beta-thalassemia in mice
c1 European Medicines Agency (EMA), Scientific Committee members and experts
9c Blood Disorders Mechanics Deconstructed
c0 Hormone's Crucial Role in 2 Anemic Blood Disorders Revealed 2 b
103 Researchers Discover Hormone that Controls Supply of Iron in Red Blood Cell Production
60 Development minihepcidin compound
d8 Medgenics Announces Beta Thalassemia Research Program
c0 Perspective: Speed Networking for Scientists
c3 Dr. Rivella and team find new gene therapy approach
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Education:
21 8 BSc c
2c University of Pavia, 1990.
21 8 PhD c
2c University of Pavia, 1999.
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Permanent link21 8 BSc c
2c University of Pavia, 1990.
21 8 PhD c
2c University of Pavia, 1999.
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210 Chappell ME, Breda L, Tricoli L, Guerra A, Jarocha DJ, Castruccio Castracani C, Papp TE, Tanaka N, Hamilton N, Triebwasser MP, Ghiaccio V, Fedorky M, Gollomp K, Bochenek V, Roche AM, Everett JK, Cook EJ, Bushman FD, Teawtrakul N, Glentis S, Kattamis A Prof, Mui BL, Tam YK, Weissman D, Abdulmalik O, Parhiz H, Rivella S.: Use of HSC Targeted LNP to Generate a Mouse Model of Lethal α-Thalassemia and Treatment via Lentiviral Gene Therapy. Blood Jul 2024.
e9 Rivella S.: Optimizing lentiviral genomic integrations to cure beta-thalassemia: The least required for success? Mol Ther Methods Clin Dev 32: 101222, Mar 2024.
19c Tricoli L, Sase S, Hacker J, Pham V, Smith S, Chappell M, Breda L, Hurwitz S, Tanaka N, Castracani CC, Guerra A, Hou Z, Schlotawa L, Radhakrishnan K, Kurre P, Ahrens-Nicklas R, Adang L, Vanderver A, Rivella S.: Effective Gene Therapy for Metachromatic Leukodystrophy Achieved with Minimal Lentiviral Genomic Integrations. bioRxiv Mar 2024.
101 Guerra A, Hamilton N, Rivera A, Demsko P, Guo S, Rivella S.: Combination of a TGF-β ligand trap (RAP-GRL) and TMPRSS6-ASO is superior for correcting β-thalassemia. Am J Hematol 2024.
f0 Castro OL, De Franceschi L, Ganz T, Kanter J, Kato GJ, Pasricha SR, Rivella S, Wood JC.: Iron restriction in sickle cell disease: When less is more. Am J Hematol 2024.
13c Liang R, Lin M, Menon V, Qiu J, Menon A, Breda L, Arif T, Rivella S, Ghaffari S.: Elevated CDKN1A (P21) mediates β-thalassemia erythroid apoptosis, but its loss does not improve β-thalassemic erythropoiesis. Blood Adv 7: 6873-6885, Nov 2023.
dc Ginzburg Y, An X, Rivella S, Goldfarb A.: Normal and dysregulated crosstalk between iron metabolism and erythropoiesis. Elife 12: e90189, Aug 2023.
156 Breda L, Papp TE, Triebwasser MP, Yadegari A, Fedorky MT, Tanaka N, Abdulmalik O, Pavani G, Wang Y, Grupp SA, Chou ST, Ni H, Mui BL, Tam YK, Weissman D, Rivella S, Parhiz H.: In vivo hematopoietic stem cell modification by mRNA delivery. Science 381: 436-443, Jul 2023.
104 Guerra A, Parhiz H, Rivella S.: Novel potential therapeutics to modify iron metabolism and red cell synthesis in diseases associated with defective erythropoiesis. Haematologica Jun 2023.
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Selected Publications
195 Pham V, Tricoli L, Hong X, Wongkittichote P, Castruccio Castracani C, Guerra A, Schlotawa L, Adang LA, Kuhs A, Cassidy MM, Kane O, Tsai E, Presa M, Lutz C, Rivella SB, Ahrens-Nicklas RC.: Hematopoietic stem cell gene therapy improves outcomes in a clinically relevant mouse model of multiple sulfatase deficiency. Mol Ther Aug 2024.210 Chappell ME, Breda L, Tricoli L, Guerra A, Jarocha DJ, Castruccio Castracani C, Papp TE, Tanaka N, Hamilton N, Triebwasser MP, Ghiaccio V, Fedorky M, Gollomp K, Bochenek V, Roche AM, Everett JK, Cook EJ, Bushman FD, Teawtrakul N, Glentis S, Kattamis A Prof, Mui BL, Tam YK, Weissman D, Abdulmalik O, Parhiz H, Rivella S.: Use of HSC Targeted LNP to Generate a Mouse Model of Lethal α-Thalassemia and Treatment via Lentiviral Gene Therapy. Blood Jul 2024.
e9 Rivella S.: Optimizing lentiviral genomic integrations to cure beta-thalassemia: The least required for success? Mol Ther Methods Clin Dev 32: 101222, Mar 2024.
19c Tricoli L, Sase S, Hacker J, Pham V, Smith S, Chappell M, Breda L, Hurwitz S, Tanaka N, Castracani CC, Guerra A, Hou Z, Schlotawa L, Radhakrishnan K, Kurre P, Ahrens-Nicklas R, Adang L, Vanderver A, Rivella S.: Effective Gene Therapy for Metachromatic Leukodystrophy Achieved with Minimal Lentiviral Genomic Integrations. bioRxiv Mar 2024.
101 Guerra A, Hamilton N, Rivera A, Demsko P, Guo S, Rivella S.: Combination of a TGF-β ligand trap (RAP-GRL) and TMPRSS6-ASO is superior for correcting β-thalassemia. Am J Hematol 2024.
f0 Castro OL, De Franceschi L, Ganz T, Kanter J, Kato GJ, Pasricha SR, Rivella S, Wood JC.: Iron restriction in sickle cell disease: When less is more. Am J Hematol 2024.
13c Liang R, Lin M, Menon V, Qiu J, Menon A, Breda L, Arif T, Rivella S, Ghaffari S.: Elevated CDKN1A (P21) mediates β-thalassemia erythroid apoptosis, but its loss does not improve β-thalassemic erythropoiesis. Blood Adv 7: 6873-6885, Nov 2023.
dc Ginzburg Y, An X, Rivella S, Goldfarb A.: Normal and dysregulated crosstalk between iron metabolism and erythropoiesis. Elife 12: e90189, Aug 2023.
156 Breda L, Papp TE, Triebwasser MP, Yadegari A, Fedorky MT, Tanaka N, Abdulmalik O, Pavani G, Wang Y, Grupp SA, Chou ST, Ni H, Mui BL, Tam YK, Weissman D, Rivella S, Parhiz H.: In vivo hematopoietic stem cell modification by mRNA delivery. Science 381: 436-443, Jul 2023.
104 Guerra A, Parhiz H, Rivella S.: Novel potential therapeutics to modify iron metabolism and red cell synthesis in diseases associated with defective erythropoiesis. Haematologica Jun 2023.
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