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De'Broski R. Herbert, PhD
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Publications
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Links
ab Search PubMed for articles
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ab Search PubMed for articles
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Education:
21 7 BS 19 (Microbiology) c
37 Xavier University of Louisiana, 1994.
21 8 PhD 17 (Immunology) c
34 Thomas Jefferson University, 2000.
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Permanent link21 7 BS 19 (Microbiology) c
37 Xavier University of Louisiana, 1994.
21 8 PhD 17 (Immunology) c
34 Thomas Jefferson University, 2000.
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112 Through the study of parasitic helminths and protozoa, my group has made important contributions towards understanding mechanisms controlling development of alternatively activated macrophages and Type 2 inflammation within the respiratory and gastrointestinal tract.
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Description of Research Expertise
5e regulatory networks, immunity, inflammation, tissue repair, mucosal interface8
112 Through the study of parasitic helminths and protozoa, my group has made important contributions towards understanding mechanisms controlling development of alternatively activated macrophages and Type 2 inflammation within the respiratory and gastrointestinal tract.
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1f0 Chan, P. Y., Carrera Silva, E. A., De Kouchkovsky, D., Joannas, L. D., Hao, L., Hu, D., Huntsman, S., Eng, C., Licona-Limón, P., Weinstein, J. S., Herbert, D. R., Craft, J. E., Flavell, R. A., Repetto, S., Correale, J., Burchard, E. G., Torgerson, D. G., Ghosh, S., Rothlin, C. V.: The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science 352(6281): 99-103, 2016.
112 Nair, M. G., Herbert, D. R.: Immune polarization by hookworms: taking cues from T helper type 2, type 2 innate lymphoid cells and alternatively activated macrophages. Immunology 148(2): 115-124, 2016.
175 Karo-Atar, D., Bordowitz, A., Wand, O., Pasmanik-Chor, M., Fernandez, I. E., Itan, M., Frenkel, R., Herbert, D. R., Finkelman, F. D., Eickelberg, O., Munitz, A.: A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair. Mucosal Immunol 9(1): 240-253, 2016.
129 Hung, L. Y., Sen, D., Oniskey, T. K., Nieves, W., Urisman, A., Krummel, M. F., Herbert, D. R.: Macrophage-Dependent Regeneration of Pulmonary Epithelia Requires Trefoil Factor 2 for Wnt Expression. J Immunol 196, 2016.
174 Fontana, M. F., Baccarella, A., Kellar, D., Oniskey, T. K., Terinate, P., Rosenberg, S. D., Huang, E. J., Herbert, D. R., Kim, C. C.: Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections. Parasite Immunol 37(9): 470-478, 2015.
109 Fontana, M. F., Baccarella, A., Pancholi, N., Pufall, M. A., Herbert, D. R., Kim, C. C.: JUNB is a key transcriptional modulator of macrophage activation. J Immunol 194(1): 177-186, 2015.
116 Herbert, D., Hung, L. Y., Sen, D., Oniskey, T., Kim, C., Krummel, M.: Trefoil factor 2 maintains and restores pulmonary function via promoting epithelial repair and M2 activation. J Immunol 192, 2014.
12a McBerry, C., Dias, A., Shryock, N., Lampe, K., Gutierrez, F. R., Boon, L., De'Broski, R. H., Aliberti, J.: PD-1 modulates steady-state and infection-induced IL-10 production in vivo. Eur J Immunol 44(2): 469-479, 2014.
12e Apiwattanakul, N., Thomas, P. G., Kuhn, R. E., Herbert, D. R., McCullers, J. A.: Helminth infections predispose mice to pneumococcal pneumonia but not to other pneumonic pathogens. Med Microbiol Immunol 203(5): 357-364, 2014.
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Selected Publications
152 Nieves, W., Hung, L. Y., Oniskey, T. K., Boon, L., Foretz, M., Viollet, B., Herbert, D. R.: Myeloid-Restricted AMPKα1 Promotes Host Immunity and Protects against IL-12/23p40-Dependent Lung Injury during Hookworm Infection. J Immunol 196(11): 4632-4640, 2016.1f0 Chan, P. Y., Carrera Silva, E. A., De Kouchkovsky, D., Joannas, L. D., Hao, L., Hu, D., Huntsman, S., Eng, C., Licona-Limón, P., Weinstein, J. S., Herbert, D. R., Craft, J. E., Flavell, R. A., Repetto, S., Correale, J., Burchard, E. G., Torgerson, D. G., Ghosh, S., Rothlin, C. V.: The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science 352(6281): 99-103, 2016.
112 Nair, M. G., Herbert, D. R.: Immune polarization by hookworms: taking cues from T helper type 2, type 2 innate lymphoid cells and alternatively activated macrophages. Immunology 148(2): 115-124, 2016.
175 Karo-Atar, D., Bordowitz, A., Wand, O., Pasmanik-Chor, M., Fernandez, I. E., Itan, M., Frenkel, R., Herbert, D. R., Finkelman, F. D., Eickelberg, O., Munitz, A.: A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair. Mucosal Immunol 9(1): 240-253, 2016.
129 Hung, L. Y., Sen, D., Oniskey, T. K., Nieves, W., Urisman, A., Krummel, M. F., Herbert, D. R.: Macrophage-Dependent Regeneration of Pulmonary Epithelia Requires Trefoil Factor 2 for Wnt Expression. J Immunol 196, 2016.
174 Fontana, M. F., Baccarella, A., Kellar, D., Oniskey, T. K., Terinate, P., Rosenberg, S. D., Huang, E. J., Herbert, D. R., Kim, C. C.: Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections. Parasite Immunol 37(9): 470-478, 2015.
109 Fontana, M. F., Baccarella, A., Pancholi, N., Pufall, M. A., Herbert, D. R., Kim, C. C.: JUNB is a key transcriptional modulator of macrophage activation. J Immunol 194(1): 177-186, 2015.
116 Herbert, D., Hung, L. Y., Sen, D., Oniskey, T., Kim, C., Krummel, M.: Trefoil factor 2 maintains and restores pulmonary function via promoting epithelial repair and M2 activation. J Immunol 192, 2014.
12a McBerry, C., Dias, A., Shryock, N., Lampe, K., Gutierrez, F. R., Boon, L., De'Broski, R. H., Aliberti, J.: PD-1 modulates steady-state and infection-induced IL-10 production in vivo. Eur J Immunol 44(2): 469-479, 2014.
12e Apiwattanakul, N., Thomas, P. G., Kuhn, R. E., Herbert, D. R., McCullers, J. A.: Helminth infections predispose mice to pneumococcal pneumonia but not to other pneumonic pathogens. Med Microbiol Immunol 203(5): 357-364, 2014.
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