Pablo G Cámara, PhD
Associate Professor of Genetics
Department: Genetics
Graduate Group Affiliations
Contact information
D105 Richards Building
3700 Hamilton Walk
Philadelphia, PA 19104-6145
3700 Hamilton Walk
Philadelphia, PA 19104-6145
Office: 215-746-3545
Education:
BS (Theoretical Physics)
Universidad Autonoma de Madrid, Spain, 2002.
PhD (Theoretical Physics)
Universidad Autonoma de Madrid, Spain, 2006.
Permanent linkBS (Theoretical Physics)
Universidad Autonoma de Madrid, Spain, 2002.
PhD (Theoretical Physics)
Universidad Autonoma de Madrid, Spain, 2006.
Description of Research Expertise
Research in the Camara lab is focused on the development and application of innovative computational approaches to the study of cellular heterogeneity and its role in disease. To this end, we draw ideas from topology, geometry, statistics, physics, and computer science. Combining these approaches with the use of high-throughput single-cell technologies and large-scale population studies, we aim to achieve a better understanding of the cellular composition and cell-to-cell signaling networks of tumors in relation to their genomes. We are particularly interested in deciphering the cellular ecosystem and heterotypic signaling networks of tumors of the central nervous system, both in adults and children; however, we expect our methods to be of utility to a broader community and collaborate with groups working in related areas of research.Selected Publications
Aubin, R. G., Montelongo, J., Hu, R., Gunther, E., Nicodemus, P., Camara, P. G.: Clustering-independent estimation of cell abundances in bulk tissues using single-cell RNA-seq data. Cell Reports Methods 4: 100905, 2024.Bai, Z., Feng, B., McClory, S. E., Coutinho de Oliveira, B., Diorio, C., Gregoire, C., Tao, B., Yang, L., Zhao, Z., Peng, L., Sferruzza, G., Zhou, L., Zhou, X., Kerr, J., Baysoy, A., Su, G., Yang, M., Camara, P. G., Chen, S., Tang, L.*, June, C. H.*, Melenhorst, J. J.*, Grupp, S. A.*, Fan, R.*: Single-cell CAR T atlas reveals type2 function in 8-year leukemia remission. Nature 634: 702-711, 2024.
Govek, K. W., Nicodemus, P., Lin, Y., Crawford, J., Saturnino, A. B., Cui, H., Zoga, K., Hart, M. P., Camara, P. G.: CAJAL enables analysis and integration of single-cell morphological data using metric geometry. Nature Communications 14: 3672, 2023.
Bai, Z.*, Woodhouse, S.*, Zhao, Z., Arya, R., Govek, K., Kim, D., Lundh, S., Baysoy, A., Sun, H., Deng, Y., Xiao, Y., Barrett, D. M., Myers, R. M., Grupp, S. A., June, C. H., Fan, R.#, Camara, P. G.#, Melenhorst, J. J.#: Single-cell antigen-specific activation landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL. Science Advances 8: eabj2820, 2022 Notes: #corresponding authors. *authors contributed equally.
Aubin, R. G., Montelongo, J., Camara, P. G.: ConDecon: clustering-independent estimation of cell abundances in bulk tissues using single-cell RNA-seq data. 30th Conference on Intelligent Systems for Molecular Biology (ISMB2022) 2022 Notes: Abstract selected for a poster and a talk presentation by Rachael Aubin at ISMB2022, July 10-14, 2022, Madison, WI.
Aubin, R. G., Troisi, E. C., Montelongo, J., Alghalith, A. N., Nasrallah, M. P., Santi, M., Camara, P. G.: Pro-inflammatory cytokines mediate the epithelial-to-mesenchymal-like transition of pediatric posterior fossa ependymoma. 2022 Single-Cell Cancer Biology Gordon Research Conference (GRC) 2022 Notes: Abstract selected for a poster presentation by Rachael Aubin at the 2022 GRC Conference on Single-Cell Cancer Biology, June 12-17, Easton, MA.
Govek, K. W., Crawford, J., Saturnino, A. B., Zoga, K., Hart, M. P., Camara, P. G.: A computational framework for the combined morphometric, transcriptomic, and physiological analysis of cells using metric geometry. 30th Conference on Intelligent Systems for Molecular Biology (ISMB2022) 2022 Notes: Abstract selected for a poster presentation by Kiya Govek at ISMB2022, July 10-14, 2022, Madison, WI.
Govek KW, Chen S, Sgourdou P, Yao Y, Woodhouse S, Chen T, Fuccillo MV, Epstein DJ, Camara PG: Developmental trajectories of thalamic progenitors revealed by single-cell transcriptome profiling and Shh perturbation. Cell Reports 41(10): 111768, 2022 Notes: doi: 10.1016/j.celrep.2022.111768.
Aubin, R.*, Troisi, E. C.*, Montelongo, J., Alghalith, A. N., Nasrallah, M. P., Santi, M., Camara, P. G.: Pro-Inflammatory Cytokines Mediate the Epithelial-to-Mesenchymal-Like Transition of Pediatric Posterior Fossa Ependymoma. Nature Communications 13: 3936, 2022.
Govek, K. W., Troisi, E. C., Miao, Z., Aubin, R. G., Woodhouse, S., Camara, P. G.: Single-Cell Transcriptomic Analysis of mIHC Images via Antigen Mapping. Science Advances 7(10): eabc5464, 2021.