Krithika Lingappan, MD MS PhD
Associate Professor of Pediatrics (Neonatology & Newborn Services)
Department: Pediatrics
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
Division of Neonatology
3401 Civic Center Boulevard
Philadelphia, PA 19014
Division of Neonatology
3401 Civic Center Boulevard
Philadelphia, PA 19014
Education:
MBBS (Medicine)
Kilpauk Medical College, TamilNadu Dr.MGR Medical University, India, 2002.
MS (Clinical Scientist Training Program)
Baylor College of Medicine, 2015.
PhD (Clinical Scientist Training Program)
Baylor College of Medicine Graduate School of Biomedical Sciences, 2018.
Permanent linkMBBS (Medicine)
Kilpauk Medical College, TamilNadu Dr.MGR Medical University, India, 2002.
MS (Clinical Scientist Training Program)
Baylor College of Medicine, 2015.
PhD (Clinical Scientist Training Program)
Baylor College of Medicine Graduate School of Biomedical Sciences, 2018.
Description of Research Expertise
My research focuses on reducing long-term morbidities such as chronic lung disease (bronchopulmonary dysplasia) in premature babies. Specifically, our research focuses on elucidating the mechanisms behind sex-specific differences in the incidence of BPD. In the future, this research should lead to therapeutic lung-protective strategies. There is a great need for such therapeutic strategies to improve outcomes in premature babies, given that the incidence of BPD in premature neonates has been reported to be as high as 50%. The long-term goal of this research is to develop new translational strategies, both therapeutic and diagnostic in the field of neonatal lung injury.Selected Publications
Lingappan K, Matthay MA: Unlocking the Therapeutic Code of Mesenchymal Stromal Cells. Am J Respir Crit Care Med. 211(3): 313-315, Mar 2025.Lee A, Weitkamp JH, Tune A, Couto J, Lingappan K.: Success and opportunities of the American Academy of Pediatrics Marshall Klaus research grant program in neonatal-perinatal medicine. Journal of Perinatology Page: doi: 10.1038, Oct 2024 Notes: epub.
Machut KZ, Owens L, Gadek L, Kataria-Hale J, Lingappan K, Savich R, Kushnir A, Hubbard D, Dammann CEL.: Perspectives and needs of neonatology division directors regarding gender equity. Journal of Perinatology Page: 10.1038/s41372-024-02126-8, Oct 2024 Notes: epub.
Avitabile CM, Zhang X, Ampah S, Wang Y, Ash D, Nilan K, Tingo JE, Frank DB, Jensen EA, Lingappan K, Gibbs KA.: Elevated pulmonary capillary wedge pressure, higher blood pressure, and lower cardiac index in infants with bronchopulmonary dysplasia. Int J Cardiol 411: 132246, Sep 2024 Notes: DOI:10.1016/j.ijcard.2024.132246.
Leek C, Cantu A, Sonti S, Gutierrez MC, Eldredge L, Sajti E, Xu HN, Lingappan K.: Role of sex as a biological variable in neonatal alveolar macrophages. Redox Biol 75: 103296, Aug 2024 Notes: doi: 10.1016/j.redox.2024.103296.
M.E. Cantu Gutierrez, A. Cantu, and K. Lingappan.: Modulation of the Injury Response in the Distal Lung Capillary Endothelium by Chromosomal and Gonadal Sex: Insights at Single-cell Resolution. Am J Respir Crit Care Med 209(1): A4687, 2024.
Albertina Lee, Jonathan Edwards, Abiud Cantu, Krithika Lingappan: Neonatal Hyperoxia Exposure Impacts the Atria More Than Ventricles: Implications for Prematurity Related Cardiac Disease. Poster Presentation, Pediatric Academic Societies Meeting, Toronto, Canada 2024.
Eric Horowitz, Clyde Wright, Misty Good, Kerri Machut, Kaashif Ahmed, Krithika Lingappan: A Study of NIH-Funded Physician-Scientists in Neonatal-Perinatal Medicine: an exploration of gender differences across career stages. Podium Presentation, Pediatric Academic Societies Meeting, Toronto, Canada 2024.
Lee A, Gutierrez MC, Lingappan K: Neonatal Hyperoxia Exposure Impacts the Atria More Than Ventricles: Implications for Prematurity Related Cardiac Disease. Poster Presentation, Neonatal Heart Society, NeoHeart 2024: Cardiovascular Management of the Neonate, New York, NY 2024.
Stading R, Swanson L, Xia G, Jiang W, Wang L, Couroucli X, Lingappan K, Moorthy B.: Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) augments neonatal hyperoxic lung injury: Role of cytochrome P450 (CYP)1A1, 1A2, and 1B1. Free Radic Biol Med 211: 35-46, December 2023.