Selected Publications

O'Connell S, Brown BC, Cannon DM, Broin PÓ, Parker N, Alnæs D, Westlye LT, Banerjee S, Nabulsi L, Corley E, Andreassen OA, Knowles DA, Mullins N.: Deriving Mendelian Randomization-Based Causal Networks of Brain Imaging Phenotypes and Bipolar Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging 2026.

Garai S, Vo S, Blank L, Xu F, Chen J, Duong-Tran D, Zhao Y, Brown BC, Shen L.: H-VIP: quantifying regional topological contributions of the brain network to cognition. Front Radiol 5: 1686780, Dec 2025.

Brown BC, Tokolyi A, Morris JA, Lappalainen T, Knowles DA.: Large-scale causal discovery using interventional data sheds light on gene network structure in k562 cells. Nat Commun 16: 9628, Oct 2025.

Silva Kasela, Francois Arguet, Sarah Kim-Hellmuth, Brielin C Brown, Daniel C Nachun, Russell P Tracy, Peter Durda, Yongmei Liu, Kent D Taylor, W Craig Johnson, David Van Den Berg, Stacey Gabriel, Namrata Gupta, Joshua D Smith, Thomas W Blackwell, Jerome I Rotter, Kristin G Ardlie, Ani Manichaikul, Stephen S Rich, R Graham Barr, Tuuli Lappalainen: Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects. American Journal of Human Genetics 111(1): 133-149, January 2024 Notes: DOI: 10.1016/J.AJHG.2023.11.013.

B.C. Brown, C. Wang, S. Kasela, F. Aguet, D.C. Nachun, K.D. Taylor, R.P. Tracy, P. Durda, Y. Liu, W.C. Johnson, D. Van Den Berg, N. Gupta, S. Gabriel, J.D. Smith, R. Gerzsten, C. Clish, Q. Wong, G. Papanicolau, T.W. Blackwell, J.I. Rotter, S.S. Rich, R.G Barr, K.G. Ardlie, D.A. Knowles, and T. Lappalainen : Multiset correlation and factor analysis enables exploratory analysis of multi-omic data. Cell Genomics 3(8): 100359, July 2023.

B.C. Brown and D. A. Knowles : Welch-weighted Egger regression reduces false positives due to correlated pleiotropy in Mendelian randomization. The American Journal of Human Genetics 108(12): 2319–2335, December 2021.

B.C. Brown and D. A. Knowles : Phenome-scale causal network discovery with bidirectional mediated Mendelian randomization. bioRxiv June 2020 Notes: doi: https://doi.org/10.1101/2020.06.18.160176.

M. Lam, C. Chen, Z. Li, A.R. Martin, J. Bryois, X. Ma, H. Gaspar, M. Ikeda, B. Benyamin, B.C. Brown, R. Liu, W. Zhou, L. Guan, Y. Kamatani, S. Kim, M. Kubo, A.A.A.A. Kusumawardhani, C. Liu, H. Ma, S. Periyasamy, A. Takahashi, Z. Xu, H. Yu, F. Zhu, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Indonesia Schizophrenia Consortium, Genetic REsearch on schizophreniA neTwork-China and the Netherlands (GREAT-CN), W.J. Chen, S. Faraone, S.J. Glatt, L. He, S.E. Hyman, H. Hwu, S.A. McCarroll, B.M. Neale, P. Sklar, D.B. Wildenauer, X. Yu, D. Zhang, B.J. Mowry, J. Lee, P. Holmans, S. Xu, P.F. Sullivan, S. Ripke, M.C. O’Donovan, M.J. Daly, S. Qin, P. Sham, N. Iwata, K.S. Hong, S.G. Schwab, W. Yue, M. Tsuang, J. Liu, X. Ma, R.S. Kahn, Y. Shi and H. Huang: Comparative genetic architectures of schizophrenia in East Asian and European populations. Nature Genetics 51: 1670–1678, November 2019.

K.J. Galinsky, Y.A. Reshef, H.K. Finucane, P. Loh, N. Zaitlen, N.J. Patterson, B.C. Brown, and A.L. Price: Estimating cross-population genetic correlations of causal effect sizes. Genetic Epidemiology 43(2): 180-188, March 2019.

B.C. Brown, N.L. Bray and L. Pachter : Expression Reflects Population Structure. PLOS Genetics 14 (12): e100784, December 2018.