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Peter F. Davies, Ph.D., Sc.D.
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Emeritus Professor of Pathology and Laboratory Medicine
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Department: Pathology and Laboratory Medicine
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Graduate Group Affiliations
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- Pharmacology e
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Publications
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Education:
21 a B.Sc. 31 (Chemistry/Ag. Biochemistry (w/Hons.)) c
3a University of Newcastle-upon-Tyne, 1969.
21 a M.Sc. 19 (Biochemistry) c
3d University of Victoria, B.C., Canada, 1972.
21 a Ph.D. 23 (Experimental Pathology) c
31 University of Cambridge, 1975.
21 a Sc.D. 1d (Higher Doctorate) c
30 University of Cambridge, 2015.
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21 a B.Sc. 31 (Chemistry/Ag. Biochemistry (w/Hons.)) c
3a University of Newcastle-upon-Tyne, 1969.
21 a M.Sc. 19 (Biochemistry) c
3d University of Victoria, B.C., Canada, 1972.
21 a Ph.D. 23 (Experimental Pathology) c
31 University of Cambridge, 1975.
21 a Sc.D. 1d (Higher Doctorate) c
30 University of Cambridge, 2015.
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Links
d4 Search PubMed for articles
82 Institute for Medicine and Engineering research
41 Pharmacological Sciences graduate group faculty
45 Cell and Molecular Biology graduate group faculty
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Permanent linkd4 Search PubMed for articles
82 Institute for Medicine and Engineering research
41 Pharmacological Sciences graduate group faculty
45 Cell and Molecular Biology graduate group faculty
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b0 Biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Stents, Cytoskeletal and membrane biophysics. Genomics and epigenomics of the endothelium.
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d8 Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, systems biology, systems biology, endothelial genomics.
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26 Description of Research
1bb Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Systems biology of the endothelium. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics, computational fluid dynamics, endocardial endothelium and 4D-flow MRI.
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Description of Research Expertise
2a Research Interestsb0 Biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Stents, Cytoskeletal and membrane biophysics. Genomics and epigenomics of the endothelium.
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d8 Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, systems biology, systems biology, endothelial genomics.
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26 Description of Research
1bb Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Systems biology of the endothelium. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics, computational fluid dynamics, endocardial endothelium and 4D-flow MRI.
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Description of Other Expertise
2c Biophysics; Lipid metabolisme 29
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123 Davies PF, Manduchi E, Stoeckert CJ, Jiménez JM, Jiang Y-Z: Biofluids, Cell Mechanics and Epigenetics: Flow-induced Epigenetic Mechanisms of endothelial gene expression. Journal of Biomechanics 50: 3-10, January 2017.
15f McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd, Jiang Y-Z, Barker AJ, Markl M, Stoeckert CJ, Davies PF.: Spatial phenotyping of the endocardial endothelium as a function of intracardiac hemodynamic shear stress. Journal of Biomechanics 50: 11-19, January 2017.
cd Davies PF, Manduchi E, Stoeckert CJ, Jiang YZ: Endothelial epigenetics and its role in mediating biomechanical stress of hypertension. J. Hypertension 40 34; Suppl 1-ISH 2016: e371, September 2016.
1c1 McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd, Jiang Y-Z, Barker AJ, Markl M, Stoeckert CJ, Davies PF.: Integrated regional cardiac hemodynamic imaging and RNA sequencing reveals corresponding heterogeneity of ventricular wall shear stress and the endocardial transcriptome. J Am Heart Assoc 18;5(4). pii: e003170.: doi: 10.1161/JAHA.115.003170, April 2016.
119 Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, Fu J, Xia L, Davies PF, Kahn ML.: Lymph flow regulates collecting lymphatic vessel maturation in vivo. J. Clin Invest. 125: 2995-3007, August 2015.
110 Jiang, Y-Z, Manduchi, E, Stoeckert CJ, Davies PF.: Arterial endothelial methylome: Differential DNA methylation in athero-susceptible disturbed flow regions in vivo. BMC Genomics 16: 506, July 2015.
131 Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR. : Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. J Controlled Release 210: 39-47, July 2015.
13d Chacko A-M, Han J, Zern BJ, Greineder C, Mikitsch JL, Nayak M, Menon D, Poncz M, Johnston I, Eckman D, Davies PF, Muzykantov VR. : Collaborative enhancement of endothelial nanocarrier targeting by modulating PECAM-1/CD31 epitope engagement. Am. Chem. Soc. Nano. 31 9(7): 6785-6793, July 2015.
125 Jiang Y-Z, Manduchi E, Jimenez JM, Davies PF. : Endothelial epigenetics in biomechanical stress: Disturbed flow-mediated epigenomic plasticity in vivo and in vitro. Arterioscler Thromb Vasc Biol 35: 1317-1326, June 2015.
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Selected Publications
fc Davies P.F.: In: LabStudio: Design Research Between Architecture & Biology. Routledge / Taylor and Francis Sabin J and Jones P. (eds.). Routledge / Taylor and Francis, Nov 2017.123 Davies PF, Manduchi E, Stoeckert CJ, Jiménez JM, Jiang Y-Z: Biofluids, Cell Mechanics and Epigenetics: Flow-induced Epigenetic Mechanisms of endothelial gene expression. Journal of Biomechanics 50: 3-10, January 2017.
15f McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd, Jiang Y-Z, Barker AJ, Markl M, Stoeckert CJ, Davies PF.: Spatial phenotyping of the endocardial endothelium as a function of intracardiac hemodynamic shear stress. Journal of Biomechanics 50: 11-19, January 2017.
cd Davies PF, Manduchi E, Stoeckert CJ, Jiang YZ: Endothelial epigenetics and its role in mediating biomechanical stress of hypertension. J. Hypertension 40 34; Suppl 1-ISH 2016: e371, September 2016.
1c1 McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd, Jiang Y-Z, Barker AJ, Markl M, Stoeckert CJ, Davies PF.: Integrated regional cardiac hemodynamic imaging and RNA sequencing reveals corresponding heterogeneity of ventricular wall shear stress and the endocardial transcriptome. J Am Heart Assoc 18;5(4). pii: e003170.: doi: 10.1161/JAHA.115.003170, April 2016.
119 Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, Fu J, Xia L, Davies PF, Kahn ML.: Lymph flow regulates collecting lymphatic vessel maturation in vivo. J. Clin Invest. 125: 2995-3007, August 2015.
110 Jiang, Y-Z, Manduchi, E, Stoeckert CJ, Davies PF.: Arterial endothelial methylome: Differential DNA methylation in athero-susceptible disturbed flow regions in vivo. BMC Genomics 16: 506, July 2015.
131 Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR. : Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. J Controlled Release 210: 39-47, July 2015.
13d Chacko A-M, Han J, Zern BJ, Greineder C, Mikitsch JL, Nayak M, Menon D, Poncz M, Johnston I, Eckman D, Davies PF, Muzykantov VR. : Collaborative enhancement of endothelial nanocarrier targeting by modulating PECAM-1/CD31 epitope engagement. Am. Chem. Soc. Nano. 31 9(7): 6785-6793, July 2015.
125 Jiang Y-Z, Manduchi E, Jimenez JM, Davies PF. : Endothelial epigenetics in biomechanical stress: Disturbed flow-mediated epigenomic plasticity in vivo and in vitro. Arterioscler Thromb Vasc Biol 35: 1317-1326, June 2015.
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