Lewis A. Chodosh, M.D., Ph.D.

faculty photo
Professor of Cancer Biology
Department: Cancer Biology

Contact information
421 Curie Blvd.
Philadelphia, PA 19104
Office: (215) 898-1321
Fax: (215) 573-6725
Lab: (215) 898-0006
B.S. (Molecular Biophysics & Biochemistry)
Yale University, 1981.
Ph.D. (Biochemistry)
Massachusetts Institute of Technology, 1988.
Harvard Medical School, 1989.
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Description of Research Expertise

Research Interests
Genetically engineered mouse models for breast cancer initiation, metastasis, and recurrence.
Normal developmental biology of the mammary gland.
Tumor dormancy.
Stem cells in breast cancer and mammary development.
Oncogenes and tumor suppressors in breast cancer.
Genomics and computational biology.
Non-invasive imaging.

Key words: Mouse models, cancer, oncogenes, targeted therapy, development, genomics, computational biology, stem cells, imaging.

Description of Research
Breast cancer is the most common cancer as well as the leading cause of death from cancer among women worldwide. The Chodosh laboratory uses genetically engineered mouse models to study the genes and mechanisms that cause breast cancer and that contribute to cancer mortality. Particular areas of interest include: critical pathways regulating breast cancer development, metastasis, tumor dormancy and recurrence; the role of stem cells in cancer and the normal development of the mammary gland; the use of genomics and computational approaches to understand genetic programs in mammary development and breast cancer; the mechanisms by which pregnancy protects against breast cancer; and the use of non-invasive imaging approaches to study tumor biology. These approaches employ a broad array of molecular, cellular, animal, human, and in silico model systems to study the function of key regulatory molecules in mammary gland and tumor biology.

Rotation Projects for 2015-2016
Rotation projects are available in each of the main areas of the lab.

Lab personnel:
George Belka – Director D
Tatiana Blanchard – Research Specialist
Yan Chen – Research Specialist
Beth Chislock, Ph.D. – Postdoctoral Researcher
Joseph Kim – Undergraduate Student
Samuel Getchell – Graduate Student
Pingyu Liu, Ph.D. – Postdoctoral Researcher
Samyutkta Mahendra – Research Specialist
Heather Martin, Ph.D. – Postdoctoral Fellow
Tien–chi Pan – Computational Biologist
Dhruv Pant – Computational Biologist
Matt Paul – Graduate Student
Lauren Pferdehirt, Ph.D. – Postdoctoral Researcher
Gabriella Puig – Undergraduate Student
Judith Smith – Lab Manager
Chris Sterner – Research Specialist
Archit Trivedi, Ph.D. – Postdoctoral Researcher

Administrative Coordinator:
Katelyn Wichert

Selected Publications

Abravanel DL, Belka GK, Pan TC, Pant DK, Collins MA, Sterner CJ and Chodosh LA: Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy. Journal of Clinical Investigation 2015.

Alvarez JV, Belka GK, Pan TC, Chen CC, Blankemeyer E, Alavi A, Karp JS and Chodosh LA: Oncogene pathway activation in mammary tumors dictates FDG-PET uptake. Cancer Research 74: 7583-7598, 2014.

Feng Y, Pan TC, Pant DK, Chakrabarti KR, Alvarez JV, Ruth JR and Chodosh LA: SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling. Cancer Discovery Page: 790-803, 2014.

Alvarez JV, Pan TC, Ruth J, Feng Y, Zhou AY, Pant D, Grimley JS, Wandless TJ, DeMichele A, I-SPY 1 Trial Investigators and Chodosh LA: Par-4 down-regulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy. Cancer Cell 24: 30-44, 2013.

Yeh ES, Belka GK, Vernon AE, Chen CC, Jung JJ and Chodosh LA: Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten. Proceedings of the National Academy of Sciences USA 115: 918-27, 2013.

Chen CC, Stairs DB, Boxer RB, Belka GK, Horseman ND, Alvarez JV and Chodosh LA: Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. Genes & Development 26: 2154-2168, 2012.

Wertheim GBW, Yang TW, Pan TC, Ramne A, Liu Z, Gardner HP, Dugan KD, Kristel P, Kreike B, Vijver MJ, Cardiff RD and Chodosh LA: The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. Proceedings of the National Academy of Sciences USA 106(37): 15855-15860, 2009.

Sarkisian CJ, Keister BA, Stairs DB, Boxer RB, Moody SE, and Chodosh LA: Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nature Cell Biology 9: 493-505, 2007.

Boxer RB, Stairs DB, Dugan KD, Notarfrancesco KL, Portacarrero CP, Keister BA, Belka GK, Cho H, Rathmell J, Thompson CB, Birnbaum MJ, and Chodosh LA: Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation Cell Metabolism 4: 475-490, 2006.

Moody SE, Perez D, Pan TC, Sarkisian CJ, Portocarrero C, Sterner CJ, Notarfrancesco K, Cardiff RD and Chodosh LA: The transcriptional repressor, Snail, promotes mammary tumor recurrence. Cancer Cell 8: 197-209, 2005.

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Last updated: 10/05/2015
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