Ronald N Harty, Ph.D.
3800 Spruce St
Philadelphia, PA 19104-6049
Fax: (215) 898-7887
Lab: (215) 573 8567
University of Lowell, Massachusetts, 1985.
Louisiana State University Medical Center, 1991.
Mount Sinai School of Medicine, New York, 1993.
Description of Research ExpertiseOur research is focused on three main areas:
1. The molecular dynamics and biological significance of virus-host interactions during late stages of RNA virus assembly and egress.
2. The identification and development of host-oriented therapeutics as a new class of antiviral inhibitors.
3. The interplay between the host innate immune response and RNA virus infection.
Our model virus systems to interrogate these topics include:
Filoviruses (Ebola and Marburg viruses)
Arenaviruses (Lassa fever and Junín viruses)
Retroviruses (HIV-1 and HTLV-1)
Selected PublicationsHan Ziying, Schwoerer Michael P, Hicks Philip, Liang Jingjing, Ruthel Gordon, Berry Corbett T, Freedman Bruce D, Sagum Cari A, Bedford Mark T, Sidhu Sachdev S, Sudol Marius, Harty Ronald N: Host Protein BAG3 is a Negative Regulator of Lassa VLP Egress. Diseases (Basel, Switzerland) 6(3), Jul 2018.
Han Ziying, Sagum Cari A, Takizawa Fumio, Ruthel Gordon, Berry Corbett T, Kong Jing, Sunyer J Oriol, Freedman Bruce D, Bedford Mark T, Sidhu Sachdev S, Sudol Marius, Harty Ronald N: Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate Egress. Journal of virology 91(20), 10 2017.
Liang Jingjing, Sagum Cari A, Bedford Mark T, Sidhu Sachdev S, Sudol Marius, Han Ziying, Harty Ronald N: Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. PLoS pathogens 13(1): e1006132, 01 2017.
Han Ziying, Sagum Cari A, Bedford Mark T, Sidhu Sachdev S, Sudol Marius, Harty Ronald N: ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding. Journal of virology 90(20): 9163-71, 10 2016.
Loughran H Marie, Han Ziying, Wrobel Jay E, Decker Sarah E, Ruthel Gordon, Freedman Bruce D, Harty Ronald N, Reitz Allen B: Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress. Bioorganic & medicinal chemistry letters 26(15): 3429-35, 08 2016.
Han Ziying, Madara Jonathan J, Herbert Andrew, Prugar Laura I, Ruthel Gordon, Lu Jianhong, Liu Yuliang, Liu Wenbo, Liu Xiaohong, Wrobel Jay E, Reitz Allen B, Dye John M, Harty Ronald N, Freedman Bruce D: Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention. PLoS pathogens 11(10): e1005220, Oct 2015.
Han Ziying, Lu Jianhong, Liu Yuliang, Davis Benjamin, Lee Michael S, Olson Mark A, Ruthel Gordon, Freedman Bruce D, Schnell Matthias J, Wrobel Jay E, Reitz Allen B, Harty Ronald N: Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses. Journal of virology 88(13): 7294-306, Jul 2014.
Lu Jianhong, Han Ziying, Liu Yuliang, Liu Wenbo, Lee Michael S, Olson Mark A, Ruthel Gordon, Freedman Bruce D, Harty Ronald N: A host-oriented inhibitor of Junin Argentine hemorrhagic fever virus egress. Journal of virology 88(9): 4736-43, May 2014.
Okumura, Atsushi, Pitha, Paula M., Yoshimura, Akihiko, Harty, Ronald N.: Interaction between Ebola Virus Glycoprotein and Host Toll-Like Receptor 4 Leads to Induction of Proinflammatory Cytokines and SOCS1. journal of virology 84(1): 27-33, JAN 2010 2010.
Okumura, Atsushi. Pitha, Paula M. Harty, Ronald N.: ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity. Proceedings of the National Academy of Sciences of the United States of America 105(10): 3974-9, Mar 11 2008.