Faculty

Kristopher R. Bosse, MD

Assistant Professor of Pediatrics (Oncology)

Department: Pediatrics

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Children's Hospital of Philadelphia
3501 Civic Center Boulevard, CTRB 3050
Philadelphia, PA 19104

Office: 651-492-6726
Fax: 267-426-0685

Email:
bossek@chop.edu

Education:
BA (Biochemistry )
Bowdoin College, 2002.
MD (Medicine)
University of Pennsylvania School of Medicine, 2010.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Grothusen GP*, Said H*, McDaid KS, Cresswell-clay E, Matlaga S, El-Mayta R, Bosse KR*, Alameh M-H*, and Pascual-Pasto G*. *, these authors contributed equally. : Restoration of Rb tumor suppressor function in retinoblastoma with intravitreal GPC2-targeted RB1 mRNA lipid nanoparticles. ACS-Nano 2026, submitted.

Schürch PM, Zecchino VP, Giudice AM, Kaufman RS, Cresswell-Clay E, Pascual-Pasto G, Roth SL, McIntyre BC, Shraim R, Hamilton AK, Parikh K, Conkrite KL, Trang KB, Grothusen GP, Groff D, Mishra P, Lombardi S, Skinner T, Wells AD, Grant S.F.A., Martinez D, Li W, Diskin SJ, Bosse KR: Selective targeting of the α3β4 nicotinic acetylcholine receptor by dual interacting subunit complex CAR T cells. Cancer Discovery 2026, Under review.

Pan H, Nelson B, Joshi N, Roth SL, Harvey K, Pascual-Pasto G, McDaid KS, Assenmacher CA, Schürch PM, Zecchino VP, Liu J, Yu J, Madsen PJ, Bosse KR*, Foster JB*. *, these authors contributed equally : Locoregional delivery of GPC2 CAR T cells is safe and effective in preclinical models of pediatric central nervous system tumors. Neuro-oncology 2026, Under re-review.

Zhang H-F, De-Dreuzy E, Huang YZ, Shin S, Huang Q, Delaidelli a , Yang X , Adamiak V , Lytle1 A, Arzoo A , Lizardo MM, Lin Q, Rouleau M, Liu L , Xu L-Y, Li W , Lai R, Primus C, Sayed SRE, Bourhis L, Genin D, Demontrond L, Bouquet L, Demolis L, Barberot A, Lameynardie S, Delabrière A, Hua H, Yang J, Ishima R, Imle R, Banito A, Savage KJ, Maris JM, Bosse KR, Dimitrov D, Steidl C, Li W, Sainson RCA, Sorensen PH: IL1RAP antibody-drug conjugates potently target primary and metastatic disease in multiple oncofusion-driven cancers. Cancer Discovery 2026, In press.

Brosius SN, Sussman JH, DiStefano IA, Grothusen GP, Natan KN, Seka I, Foltz S, Labella K, Dr. Bosse KR, Tan K, De Raedt T : Identification of CD74-positive antigen presenting glioma cells in primary human tumors and murine models of NF1 high-grade glioma. Molecular Cancer Therapeutics 2026, In press.

Schuerch P (presenter)...Bosse KR: Selective targeting of the α3β4 nicotinic acetylcholine receptor by DISCO (dual interacting subunit complex) CAR T cells. Talk presented at the American Association of Cancer Research Annual Meeting, San Diego, CA. April 2026.

Schuerch PM (presenter), Draper B, Zecchino VP, Pan H, Nelson B, Giudice AM, Foster JB, Donovan LK, Bosse KR : Co-targeting GPC2 and B7-H3 with CAR T cells achieves durable responses in preclinical high-risk neuroblastoma and medulloblastoma models. Talk presented at the American Association of Cancer Research Annual Meeting, San Diego, CA. April 2026.

Fraietta JA, Minehart J, and Bosse KR.: Rewiring Immunotherapy for High-Risk Neuroblastoma. Virtual, ImmunoLogic, Episode 9 March 2026.

Pan H, Foster J, Bosse KR: Scratching the surface of targeting GPC2 in pediatric CNS tumors. Molecular Therapy Oncology 33(4), December 2025.

Giudice AM, Matlaga S, Roth SL, Pascual-Pasto G, Schürch P, Rouin G, McIntyre B, Grothusen GP, Cresswell-clay E, Shraim R, Groff D, Zecchino V, Lombardi S, Martinez D, Spruce LA, Brown EM, Fazelinia H, Henrickson SE, Nance J, Reynolds CP, Bosse KR : Target antigen-displaying extracellular vesicles boost CAR T cell efficacy in cell and mouse models of neuroblastoma. Science Translational Medicine 17(825), November 2025.