Faculty

Raymond Edward Soccio, MD, PhD

faculty photo
Assistant Professor of Medicine
Department: Medicine

Contact information
Smilow Center for Translational Research, Rm 12-112
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: (215) 370-0515
Fax: (215) 898-5408
Lab: (215) 573-4576
Education:
BA (Biochemical Sciences, summa cum laude)
Harvard University, Cambridge, MA, 1997.
PhD (Biomedical Sciences)
Rockefeller University, New York, NY, 2004.
MD
Weill Medical College of Cornell University, New York, NY, 2005.
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Description of Clinical Expertise

Obesity, Metabolic Syndrome

Description of Research Expertise

Nuclear Receptors, Genetics of Gene Regulation, Lipid Metabolism

Selected Publications

Soccio, RE: Chapter 28: Hepatic Nuclear Receptors. The Liver: Biology and Pathobiology, Sixth Edition. John Wiley & Sons Ltd. 2020.

Shen Y, Su Y, Silva FJ, Weller AH, Sostre-Colón J, Titchenell PM, Steger DJ, Seale P, Soccio RE: Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function. Cell Reports 30: 3079, 2020.

Yachen Shen, Yvonne Su, Angela Weller, Raymond Soccio: PPARα and PPARγ gene regulation in brown fat thermogenesis. Cold Spring Harbor Mechanisms of Metabolic Signalling Meeting, NY May 2019.

Kiara K. Benson, Wenxiang Hu, Angela H. Weller, Alexis H. Bennett, Eric R. Chen, Sumeet A. Kheterpal, Satoshi Yoshino, Wang L, Joshua D. Rabinowitz, Benjamin F. Voight, Mitchell A. Lazar, Raymond E. Soccio: Natural Genetic Variation in Humans Determines Basal and Inducible Expression of PM20D1, a Putative Thermogenic Gene. Endocrine Society Annual Meeting, New Orleans, LA March 2019.

Hu Wenxiang, Jiang Chunjie, Guan Dongyin, Dierickx Pieterjan, Zhang Rong, Moscati Arden, Nadkarni Girish N, Steger David J, Loos Ruth J F, Hu Cheng, Jia Weiping, Soccio Raymond E, Lazar Mitchell A: Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response. Cell stem cell 24(2): 299-308.e6, Feb 2019.

Benson, Kiara K; Hu, Wenxiang; Weller, Angela H; Bennett, Alexis H; Chen, Eric R; Khetarpal, Sumeet A; Yoshino, Satoshi; Bone, William P; Wang, Lin; Rabinowitz, Joshua D; Voight, Benjamin F; Soccio, Raymond E.: Natural human genetic variation determines basal and inducible expression of PM20D1, an obesity-associated gene. Proc Natl Acad Sci U S A 116: 23232, 2019.

Zhang Xuan, Xue Chenyi, Lin Jennie, Ferguson Jane F, Weiner Amber, Liu Wen, Han Yumiao, Hinkle Christine, Li Wenjun, Jiang Hongfeng, Gosai Sager, Hachet Melanie, Garcia Benjamin A, Gregory Brian D, Soccio Raymond E, Hogenesch John B, Seale Patrick, Li Mingyao, Reilly Muredach P: Interrogation of nonconserved human adipose lincRNAs identifies a regulatory role of in adipocyte metabolism. Science translational medicine 10(446), Jun 2018.

Angela H Weller, Kiara Benson, Arya Nakhe, Ioana Soatia, Yachen Shen , Raymond E Soccio: The Role of PPARα in Non-Alcoholic Fatty Liver Disease. FASEB meeting "Fundamental Biology and Pathophysiology of the Liver", Scottsdale, AZ June 2018.

Chang, Xiao; Li, Dong; Tian, Lifeng; Liu, Yichuan; March, Michael; Wang, Tiancheng; Hou, Cuiping; Pellegrino, Renata; Levy, Richard; Jen, Melinda; Soccio, Raymond; Sleiman, Patrick; Hakonarson, Hakon; Castelo-Soccio, Leslie.: Heterozygous Deletion Impacting SMARCAD1 in the Original Kindred with Absent Dermatoglyphs and Associated Features (Baird, 1964). Journal of Pediatrics 194: 248, 2018.

Soccio Raymond E, Li Zhenghui, Chen Eric R, Foong Yee Hoon, Benson Kiara K, Dispirito Joanna R, Mullican Shannon E, Emmett Matthew J, Briggs Erika R, Peed Lindsey C, Dzeng Richard K, Medina Carlos J, Jolivert Jennifer F, Kissig Megan, Rajapurkar Satyajit R, Damle Manashree, Lim Hee-Woong, Won Kyoung-Jae, Seale Patrick, Steger David J, Lazar Mitchell A: Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice. The Journal of Clinical Investigation 127(4): 1451-1462, Apr 2017.

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Last updated: 11/04/2020
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