Faculty

Kyle Bittinger, Ph.D.

Assistant Professor of Pediatrics (Gastroenterology, Hepatology and Nutrition) at the Children's Hospital of Philadelphia

Department: Pediatrics

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Children's Hospital of Philadelphia
Microbiome Center
Roberts Center for Pediatric Research
2716 South Street, 14th Floor
Philadelphia, PA 19146-2305

Office: 267-425-1641

Email:
bittingerk@chop.edu

Education:
B.S. (Chemistry)
University of Pittsburgh, 2001.
Ph.D. (Physical Chemistry)
Massachusetts Institute of Technology, 2008.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

McGann CM, Strysko J, Bayani O, Moorad B, Ntlhako N, Nwako N, Hu W, Tanes C, Moustafa AM, Jones SM, Nakstad B, Gezmu AM, Arscott-Mills T, Goldfarb DM, Steenhoff AP, Richard-Greenblatt M, Machiya T, Thela T, Mokomane M, Paganotti GM, Vurayai M, Zalot M, Boustany M, Planet PJ, Coffin S, Bittinger K: Effect of maternal HIV status on the early neonatal microbiome. J Pediatric Infect Dis Soc 14(10): piaf076, Oct 2025.

Tanes C, Hu W, Friedman E, Hecht A, Daniel S, Clish C, Lewis JD, Wu GD, Bittinger K: Distinguishing diet- and microbe-derived metabolites in the human gut. Microbiome 13(1): 206, Oct 2025.

Drake MJ, Pierdon M, DeMers G, Daniel SG, Bittinger K, Redding LE: The effect of dietary zinc on the microbiome and resistome of the gestating sow and neonatal piglets. Anim Microbiome 7(1): 71, Jul 2025.

Feigenberg SJ, Costabile F, Tanes C, Bittinger K, O'Connor R, Agarwal D, Skoufos G, Salaris S, Hatzigeorgiou A, Kostopoulos N, Lloyd S, Friedes C, Chen L, Yegya-Raman N, Cengel K, Levin W, Valentić B, Quarton T, Shestov AA, Berman A, Bradley J, Maity A, Koumenis C, Ben-Josef E, Facciabene A: Enhancing outcomes in medically inoperable early-stage NSCLC with gut-targeted antibiotics and stereotactic body radiotherapy: results from a randomized pilot study. J Immunother Cancer 13(6): e011356, Jul 2025.

Hewlett KK, PeBenito A, Hecht AL, Tiffany C, Tanes C, Glover RC, Fawad JA, Friedman ES, Reynolds JC, Bittinger K, Lewis JD, Wu GD, Ahuja NK, Zackular JP: Dietary fiber modulates the window of susceptibility to Clostridioides difficile infection. Gastroenterology Jul 2025 Notes: doi: 10.1053/j.gastro.2025.04.027. Epub ahead of print.

Mulcrone PL, Narrowe A, Jones S, Hu W, Bittinger K, Moustafa AM, Liu L, Xiao W, Firrman J: Monitoring the impact of chlorinated drinking water on the developing gut microbiota of adolescent mice using genetic profiling. Int J Environ Stud 82(3): 1210, Jun 2025.

Wong SY, Estevinho MM, Heaney T, Marshall AA, Giselbrecht E, Daniel SG, Zhou C, Rosas-Villegas A, Jang KK, Yang H, Ko HM, Paulson JD, Ding Y, Bittinger K, Cho JH, Lewis JD, Ramanan D, Cadwell K: Goblet Cell Loss Linked to NOD2 and Secondary Resection in Crohn's Disease is Induced by Dysbiosis and Epithelial MyD88. Cell Mol Gastroenterol Hepatol 15(2): 101533, May 2025.

Rotsaert C, Minnebo Y, Duysburgh C, Liu LS, Mahalak KK, Firman J, Mattei LM, Moustafa AM, Bittinger K, Hu W, Marzorati M, Michiels J, Van de Wiele T: Digestive parameters and gut microbiota load and composition along the in vivo piglet gastrointestinal tract. J Anim Sci 27(1): skaf107, May 2025 Notes: epub.

Litichevskiy L, Considine M, Gill J, Shandar V, Cox TO, Descamps HC, Wright KM, Amses KR, Dohnalová L, Liou MJ, Tetlak M, Galindo-Fiallos MR, Wong AC, Lundgren P, Kim J, Uhr GT, Rahman RJ, Mason S, Merenstein C, Bushman FD, Raj A, Harding F, Chen Z, Prateek GV, Mullis M, Deighan AG, Robinson L, Tanes C, Bittinger K, Chakraborty M, Bhatt AS, Li H, Barnett I, Davenport ER, Broman KW, Levy M, Cohen RL, Botstein D, Freund A, Di Francesco A, Churchill GA, Li M, Thaiss CA: Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice. Nat Microbiol 10(5): 1240, May 2025.

McGann C, Phyu R, Bittinger K, Mukhopadhyay S: Role of the Microbiome in Neonatal Infection: Pathogenesis and Implications for Management. Clin Perinatol 52(1): 147, Mar 2025.