Faculty

David B. Frank, MD, PhD

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
3401 Civic Center Boulevard
8NW37, Division of Pediatric Cardiology
Philadelphia, PA 19104
Office: (267) 648-2626
Fax: 215-590-1340
Education:
B.S. (Biochemistry)
University of Nebraska-Lincoln, 1997.
Ph.D. (Cell and Developmental Biology and Philosophy)
Vanderbilt University School of Medicine, 2006.
M.D.
Vanderbilt University of School of Medicine, 2009.
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Selected Publications

Bose SK, White BM, Kashyap MV, Dave A, De Bie FR, Li H, Singh K, Menon P, Wang T, Teerdhala S, Swaminathan V, Hartman HA, Jayachandran S, Chandrasekaran P, Musunuru K, Jain R, Frank DB, Zoltick P, Peranteau WH: In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease. Nat Commun July 2021.

Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R.: Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell Stem Cell 28(5), May 2021.

Penkala IJ, Liberti DC, Pankin J, Sivakumar A, Kremp MM, Jayachandran S, Katzen J, Leach JP, Windmueller R, Stolz K, Morley MP, Babu A, Zhou S, Frank DB*, Morrisey EE*: Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration. Cell Stem Cell Page: Online ahead of print, May 2021.

Frank DB, Levy PT, Stiver CA, Boe BA, Baird CW, Callahan RM, Smith CV, Vanderlaan RD, Backes CH.: Primary pulmonary vein stenosis during infancy: state of the art review. Journal of Perinatology March 2021.

Zepp JA, Morley MP, Loebel C, Kremp MM, Chaudhry FN, Basil MC, Leach JP, Liberti DC, Niethamer TK, Ying Y, Jayachandran S, Babu A, Zhou S, Frank DB, Burdick JA, Morrisey EE.: Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus. Science 371(6534), March 2021.

Obraztsova K, Basil MC, Rue R, Sivakumar A, Lin SM, Mukhitov AR, Gritsiuta AI, Evans JF, Kopp M, Katzen J, Robichaud A, Atochina-Vasserman EN, Li S, Carl J, Babu A, Morley MP, Cantu E, Beers MF, Frank DB, Morrisey EE, Krymskaya VP.: mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline. Nat Commun 11(1): 5640, Nov 2020.

Paris AJ, Hayer KE, Oved JH, Avgousti DC, Toulmin SA, Zepp JA, Zacharias WJ, Katzen JB, Basil MC, Kremp MM, Slamowitz AR, Jayachandran S, Sivakumar A, Dai N, Wang P, Frank DB, Eisenlohr LC, Cantu E 3rd, Beers MF, Weitzman MD, Morrisey EE, Worthen GS: STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury. Nat Cell Biol 22(10): 1197-1210, Oct 2020.

Vanderver A, Adang L, Gavazzi F, McDonald K, Helman G, Frank DB, Jaffe N, Yum SW, Collins A, Keller SR, Lebon P, Meritet JF, Rhee J, Takanohashi A, Armangue T, Ulrick N, Sherbini O, Koh J, Peer K, Besnier C, Scher C, Boyle K, Dubbs H, Kramer-Golinkoff J, Pizzino A, Woidill S, Shults J: Janus Kinase Inhibition in the Aicardi-Goutières Syndrome. N Engl J Med 383(10): 986-989, Sep 2020.

Catherine M Avitabile, Yan Wang, Xuemei Zhang, Heather Griffin , Sofia Saavedra, Samantha Adams, Lisa Herkert, David B Frank, Michael D Quartermain , Natalie E Rintoul , Holly L Hedrick, Laura Mercer-Rosa : Right Heart Strain, Brain Natriuretic Peptide, and Mortality in Congenital Diaphragmatic Hernia. Annals of the American Thoracic Society Online ahead of print, July 2020.

A. Naik, Y. Issah, K. Forrest, D. B. Frank, A. Paris, A. Vaughan, S. Sengupta: Role of Circadian Clock in Lung Repair and Regeneration. American Thoracic Society International Conference Abstracts > C62. EPITHELIUM, INJURY, AND REPAIR May 2020.

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Last updated: 07/26/2021
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