Faculty

David B. Frank, MD, PhD

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
3401 Civic Center Boulevard
8NW37, Division of Pediatric Cardiology
Philadelphia, PA 19104
Office: (267) 648-2626
Fax: 215-590-1340
Education:
B.S. (Biochemistry)
University of Nebraska-Lincoln, 1997.
Ph.D. (Cell and Developmental Biology and Philosophy)
Vanderbilt University School of Medicine, 2006.
M.D.
Vanderbilt University of School of Medicine, 2009.
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Selected Publications

Avitabile CM, Zhang X, Ampah SB, Wang Y, Ash D, Nilan K, Mercer-Rosa L, Fierro JL, Frank DB, Gibbs KA.: Factors associated with discontinuation of pulmonary vasodilator therapy in children with bronchopulmonary dysplasia-associated pulmonary hypertension. J Perinatology June 2022.

Nigel S. Michki, Prashant Chandrasekaran, Minqi Lu, Jennifer Pogoriler, William Peranteau, Sourav Bose, David B. Frank: Characterizing the cellular mechanisms underlying congenital pulmonary airway malformation (CPAM) development in newborns. Gordon Research Conference on Single-Cell Genomics, When Stochasticity Meets Precision in a Single Cell, May 1 - 6, 2022 May 2022.

Fernandez RJ, Gardner ZJG, Slovik KJ, Liberti DC, Estep KN, Yang W, Chen Q, Santini GT, Perez JV, Root S, Bhatia R, Tobias JW, Babu A, Morley MP, Frank DB, Morrisey EE, Lengner CJ, Johnson FB: GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells. eLife. eLife, May 2022.

Prashant Chandrasekaran*, Nicholas M. Negretti*, Aravind Sivakumar*, Maureen Peers, Joanna Wang, Sowmya Jayachandran, Hongbo Wen, Sukhmani Kaur, MinQi Lu, Lisa R. Young, Jennifer M.S. Sucre**, David B. Frank** : Deciphering molecular programming and morphogenesis of pulmonary vascular development. 2022 Annual AAP/ASCI/APSA Joint meeting April 2022.

Penkala IJ, Liberti DC, Pankin J, Sivakumar A, Kremp MM, Jayachandran S, Katzen J, Leach JP, Windmueller R, Stolz K, Morley MP, Babu A, Zhou S, Frank DB*, Morrisey EE*: Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration. Cell Stem Cell 28(10): 1775-1789, October 2021.

Chandrasekaran P, Kwok B, Han B, Adams SM, Wang C, Chery DR, Mauck RL, Dyment NA, Lu XL, Frank DB, Koyama E, Birk DE, Han L.: Type V collagen regulates the structure and biomechanics of TMJ condylar cartilage: A fibrous-hyaline hybrid. Matrix Biol. 102: 1-19, August 2021.

Frank DB, Levy PT, Stiver CA, Boe BA, Baird CW, Callahan RM, Smith CV, Vanderlaan RD, Backes CH.: Primary pulmonary vein stenosis during infancy: state of the art review. Journal of Perinatology 41(7): 1528-1539, July 2021.

Bose SK, White BM, Kashyap MV, Dave A, De Bie FR, Li H, Singh K, Menon P, Wang T, Teerdhala S, Swaminathan V, Hartman HA, Jayachandran S, Chandrasekaran P, Musunuru K, Jain R, Frank DB, Zoltick P, Peranteau WH: In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease. Nat Commun 12(1), July 2021.

Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R.: Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell Stem Cell 28(5): 938-954, May 2021.

Zepp JA, Morley MP, Loebel C, Kremp MM, Chaudhry FN, Basil MC, Leach JP, Liberti DC, Niethamer TK, Ying Y, Jayachandran S, Babu A, Zhou S, Frank DB, Burdick JA, Morrisey EE.: Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus. Science 371(6534), March 2021.

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Last updated: 08/05/2022
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